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Year Number of Results
1998 3
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2010 5
2012 3
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2015 7
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86 results

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Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.
Wang W, Gao W, Gong P, Song W, Bu X, Hou J, Zhang L, Zhao B. Wang W, et al. Cell Commun Signal. 2023 Dec 15;21(1):356. doi: 10.1186/s12964-023-01390-z. Cell Commun Signal. 2023. PMID: 38102610 Free PMC article.
METHODS: We employed recombinant adeno-associated virus 9 (AAV9)-hSyn to knockdown tumor necrosis factor alpha-induced protein 1 (TNFAIP1) or SNAP25 and investigate the role of TNFAIP1 in POCD. Cognitive performance, hippocampal injury, mitophagy, and pyroptosis wer …
METHODS: We employed recombinant adeno-associated virus 9 (AAV9)-hSyn to knockdown tumor necrosis factor alpha-induced protein 1 (TNFAIP1 …
TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
Yi J, Zhu M, Qiu F, Zhou Y, Shu P, Liu N, Wei C, Xiang S. Yi J, et al. Neurotox Res. 2020 Jun;38(1):184-198. doi: 10.1007/s12640-020-00199-9. Epub 2020 Apr 25. Neurotox Res. 2020. PMID: 32335808
However, the role of TNFAIP1 in FA-induced neurotoxicity is unclear. Herein, using a mouse neuroblastoma cell line (N2a cells), we explored the mechanism of TNFAIP1 in FA-induced neurotoxicity, the involvement of the Akt/CREB signaling pathway, and how the expressio …
However, the role of TNFAIP1 in FA-induced neurotoxicity is unclear. Herein, using a mouse neuroblastoma cell line (N2a cells), we ex …
TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB.
Xiao Y, Li Y, Zhang H, Yang L, Jiang Y, Wei C, Feng X, Xun Y, Yuan S, Xiang S, Liu N. Xiao Y, et al. J Mol Neurosci. 2021 Jun;71(6):1221-1233. doi: 10.1007/s12031-020-01748-9. Epub 2020 Nov 7. J Mol Neurosci. 2021. PMID: 33159672
In this study, our experimental results show that TNFAIP1 and p-TNFAIP1 (phosphorylation of TNFAIP1 at Ser280) are overexpressed in the neurons of the cortex and hippocampus in the brains of APP/PS1 mice, and the transcription factor NF-kappaB is involved in …
In this study, our experimental results show that TNFAIP1 and p-TNFAIP1 (phosphorylation of TNFAIP1 at Ser280) are over …
Downregulation of TNFAIP1 alleviates OGD/R-induced neuronal damage by suppressing Nrf2/GPX4-mediated ferroptosis.
Xiong L, Zhang J, Shi H, Zhu G, Ji X, Li M, Zhu P, Luo K. Xiong L, et al. Exp Ther Med. 2022 Nov 23;25(1):25. doi: 10.3892/etm.2022.11724. eCollection 2023 Jan. Exp Ther Med. 2022. PMID: 36561622 Free PMC article.
TNFalpha-induced protein 1 (TNFAIP1) serve a role in neurovascular disease. However, the potential role and molecular mechanism of TNFAIP1 in cerebral ischemia-reperfusion (I/R) remains elusive. ...TNFAIP1 knockdown inhibited ferroptosis via activation of the …
TNFalpha-induced protein 1 (TNFAIP1) serve a role in neurovascular disease. However, the potential role and molecular mechanism of …
Screening of Tnfaip1-Interacting Proteins in Zebrafish Embryonic cDNA Libraries Using a Yeast Two-Hybrid System.
Huang S, Zhang H, Chen W, Wang J, Wu Z, He M, Zhang J, Hu X, Xiang S. Huang S, et al. Curr Issues Mol Biol. 2023 Oct 10;45(10):8215-8226. doi: 10.3390/cimb45100518. Curr Issues Mol Biol. 2023. PMID: 37886961 Free PMC article.
The library titer was 1.12 10(7) CFU/mL, the recombination rate was 100%, and the average length of the inserted fragments was greater than 1000 bp. A total of 43 potential interacting proteins of Tnfaip1 were identified using zebrafish Tnfaip1 as a bait protein. .. …
The library titer was 1.12 10(7) CFU/mL, the recombination rate was 100%, and the average length of the inserted fragments was greater than …
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3beta/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF. Wen L, et al. Int Immunopharmacol. 2021 Oct;99:107993. doi: 10.1016/j.intimp.2021.107993. Epub 2021 Jul 28. Int Immunopharmacol. 2021. PMID: 34330059
However, whether TNFAIP1 plays a role in myocardial ischemia/reperfusion (I/R) injury has not been well investigated. ...Our study highlights a vital role of the TNFAIP1/Akt/GSK-3beta/Nrf2 pathway in mediating myocardial I/R injury and suggests TNFAIP1 as an …
However, whether TNFAIP1 plays a role in myocardial ischemia/reperfusion (I/R) injury has not been well investigated. ...Our study hi …
Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
Chen J, Zhao M, Fang W, Du C. Chen J, et al. Allergol Immunopathol (Madr). 2023 Jul 1;51(4):94-100. doi: 10.15586/aei.v51i4.884. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 37422785
RESULTS: TNFAIP1 expression was enhanced in the LPS-induced pneumonia mice but was negatively correlated with the LPS-induced lung injury. ...The findings suggested that TNFAIP1 is a potential candidate for pneumonia therapy....
RESULTS: TNFAIP1 expression was enhanced in the LPS-induced pneumonia mice but was negatively correlated with the LPS-induced lung in …
Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway.
Qiu F, Zhou Y, Deng Y, Yi J, Gong M, Liu N, Wei C, Xiang S. Qiu F, et al. Chemosphere. 2020 Feb;241:125114. doi: 10.1016/j.chemosphere.2019.125114. Epub 2019 Oct 14. Chemosphere. 2020. PMID: 31683445
Knockdown of TNFAIP1 using TNFAIP1 small interfering RNA (siRNA) expression vector prevented DEHP from inhibiting CREB pathway, thus reduced apoptosis and restored expression of BDNF, PSD 95 and synapsin-1. Our data indicate that downregulation of TNFAIP1 pre …
Knockdown of TNFAIP1 using TNFAIP1 small interfering RNA (siRNA) expression vector prevented DEHP from inhibiting CREB pathway …
TNFAIP1 contributes to the neurotoxicity induced by Abeta25-35 in Neuro2a cells.
Liu N, Yu Z, Xun Y, Li M, Peng X, Xiao Y, Hu X, Sun Y, Yang M, Gan S, Yuan S, Wang X, Xiang S, Zhang J. Liu N, et al. BMC Neurosci. 2016 Jul 18;17(1):51. doi: 10.1186/s12868-016-0286-3. BMC Neurosci. 2016. PMID: 27430312 Free PMC article.
Further studies showed that TNFAIP1 knockdown significantly blocked Abeta25-35-induced cleaved caspase 3, whereas TNFAIP1 overexpression enhanced Abeta25-35-induced cleaved caspase 3, suggesting that TNFAIP1 plays an important role in Abeta25-35-induced neuro …
Further studies showed that TNFAIP1 knockdown significantly blocked Abeta25-35-induced cleaved caspase 3, whereas TNFAIP1 over …
CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development.
Huang S, Zhang H, Chen W, Su N, Yuan C, Zhang J, Xiang S, Hu X. Huang S, et al. Genes (Basel). 2023 Apr 28;14(5):1005. doi: 10.3390/genes14051005. Genes (Basel). 2023. PMID: 37239365 Free PMC article.
To investigate the function of tnfaip1 during early development, we constructed a model of a stably inherited tnfaip1 mutant using the CRISPR/Cas9 system. ...These findings suggest an important role for tnfaip1 in the early development of zebrafish....
To investigate the function of tnfaip1 during early development, we constructed a model of a stably inherited tnfaip1 mutant u …
86 results