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2010 4
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TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L. Li W, et al. Autophagy. 2021 Jun;17(6):1410-1425. doi: 10.1080/15548627.2020.1761748. Epub 2020 May 28. Autophagy. 2021. PMID: 32460619 Free PMC article.
However, whether and how TNFAIP8L2 controls autophagy is still unknown. Murine TNFAIP8L2 can directly bind to and block the RAC1 GTPase activity to regulate innate immunity. ...Instead, TNFAIP8L2 appears to impair autophagic lysosome reformation (ALR) during …
However, whether and how TNFAIP8L2 controls autophagy is still unknown. Murine TNFAIP8L2 can directly bind to and block the RA …
Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism.
Li T, Wang W, Gong S, Sun H, Zhang H, Yang AG, Chen YH, Li X. Li T, et al. Mol Immunol. 2018 Jul;99:154-162. doi: 10.1016/j.molimm.2018.05.007. Epub 2018 May 19. Mol Immunol. 2018. PMID: 29787979 Free PMC article.
In addition, Tnfaip8l2 expression drastically decreased in lipopolysaccharide (LPS)-stimulated macrophages. ...Furthermore, mitochondrial respiration rate was increased in Tnfaip8l2-deficient macrophages, as measured by Seahorse metabolic analyzer. ...
In addition, Tnfaip8l2 expression drastically decreased in lipopolysaccharide (LPS)-stimulated macrophages. ...Furthermore, mitochond …
The protective mechanism of salidroside modulating miR-199a-5p/TNFAIP8L2 on lipopolysaccharide-induced MLE-12 cells.
Tan Y, Zou YF, Zhang HB, Liu X, Qian CY, Liu MW. Tan Y, et al. Int J Immunopathol Pharmacol. 2022 Jan-Dec;36:3946320221132712. doi: 10.1177/03946320221132712. Int J Immunopathol Pharmacol. 2022. PMID: 36214213 Free PMC article.
After the treatment, apoptosis of MLE-12 cells was determined, and the mRNA and protein expression of miR-199a-5p, HMGB1, NF-kB65, TNFAIP8L2, p-IkB-alpha, and TLR4 was estimated by Western Blotting and RT-PCR. ...Our results suggest that this could be by reducing miR-199a- …
After the treatment, apoptosis of MLE-12 cells was determined, and the mRNA and protein expression of miR-199a-5p, HMGB1, NF-kB65, TNFAIP …
Comprehensive analysis of tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2): A potential novel pan-cancer immune checkpoint.
Bai KH, Zhang YY, Li XP, Tian XP, Pan MM, Wang DW, Dai YJ. Bai KH, et al. Comput Struct Biotechnol J. 2022 Sep 17;20:5226-5234. doi: 10.1016/j.csbj.2022.09.021. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36187930 Free PMC article.
TIPE2 is a potential checkpoint molecule for immune cell maturation and antitumor immunity that could be used as a novel NK cell-based immunotherapeutic approach. In this study, we explored the expression of TNFAIP8L2 across various tumor types and found that TNFAIP8L2 …
TIPE2 is a potential checkpoint molecule for immune cell maturation and antitumor immunity that could be used as a novel NK cell-based immun …
Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.
Li A, Chen Y, Zhao X, Niu Y, Cong P, Zhang Z, Chen W, Jiang W, Mo D. Li A, et al. Mol Genet Genomics. 2010 Sep;284(3):185-95. doi: 10.1007/s00438-010-0558-z. Epub 2010 Jul 17. Mol Genet Genomics. 2010. PMID: 20640581
Subcellular localization analysis showed GFP-TNFAIP8L2 fusion protein distributed in nucleus as well as cytoplasm including mitochondria and endoplasmic reticulum. ...Then, site-directed mutation experiment combined with electrophoretic mobility shift assay (EMSA) indicate …
Subcellular localization analysis showed GFP-TNFAIP8L2 fusion protein distributed in nucleus as well as cytoplasm including mitochond …
Genomic identification and molecular characterization of a non-mammalian TNFAIP8L2 gene from Oplegnathus fasciatus.
Umasuthan N, Revathy KS, Whang I, Kim E, Oh MJ, Jung SJ, Lee JH, Park HC, Lee J. Umasuthan N, et al. Gene. 2014 May 25;542(1):52-63. doi: 10.1016/j.gene.2014.02.047. Epub 2014 Feb 26. Gene. 2014. PMID: 24583177
The predicted rock bream TNFAIP8L2 protein was 21.1kDa and revealed the typical features of known TNFAIP8L2 members including the DED-like domain. Rock bream TNFAIP8L2 was composed of six alpha-helices and demonstrated a distinct folding pattern of the TNF …
The predicted rock bream TNFAIP8L2 protein was 21.1kDa and revealed the typical features of known TNFAIP8L2 members including …
Research progress of TIPE2 in immune-related diseases.
Gao J, Zhang H, Zhang F. Gao J, et al. Int Immunopharmacol. 2023 Aug;121:110514. doi: 10.1016/j.intimp.2023.110514. Epub 2023 Jun 20. Int Immunopharmacol. 2023. PMID: 37348234 Review.
The tumor necrosis factor alpha-induced protein 8 (TNFAIP8) family, which consists of TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2) and TNFAIP8L3 (TIPE3), has recently emerged as a regulatory factor involved in immune response and tumorigenesis. ...
The tumor necrosis factor alpha-induced protein 8 (TNFAIP8) family, which consists of TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (T …
TIPE2: A Candidate for Targeting Antitumor Immunotherapy.
Xu L, Pan F, Guo Z. Xu L, et al. J Immunol. 2024 Mar 1;212(5):755-763. doi: 10.4049/jimmunol.2300433. J Immunol. 2024. PMID: 38377476 Review.
TNF-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a recently discovered negative regulator of innate and adaptive immunity. ...
TNF-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a recently discovered negative regulator of innate and adaptive immunity. …
TIPE2 deficiency prolongs mouse heart allograft survival by facilitating immature DCs-induced Treg generation.
Ma Y, Yang Y, Dai H, Yan C, Yu S, Zhang S, Lin Z, Chen J, Yu G, Zhang J, Yin P, Lu J, Shi C, Ye Z, Ruan Q, Qi Z, Zhuang G. Ma Y, et al. Clin Immunol. 2023 Jul;252:109636. doi: 10.1016/j.clim.2023.109636. Epub 2023 May 5. Clin Immunol. 2023. PMID: 37150242
It has been reported that deletion of tumor necrosis factor-alpha-induced protein-8 like 2 (TNFAIP8L2, TIPE2) facilitates the activation of T-cell receptors. However, the role of TIPE2 in T-cell-mediated acute transplant rejection remains unclear. ...
It has been reported that deletion of tumor necrosis factor-alpha-induced protein-8 like 2 (TNFAIP8L2, TIPE2) facilitates the activat …
136 results