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Page 1
Methotrexate chronotherapy is effective against rheumatoid arthritis.
To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K. To H, et al. Chronobiol Int. 2011 Apr;28(3):267-74. doi: 10.3109/07420528.2011.553017. Chronobiol Int. 2011. PMID: 21452922 Clinical Trial.
TNF-alpha mRNA levels showed a clear 24-h rhythm with a peak at 22 HALO and a trough at 18 HALO after RA had developed. In these MRL/lpr mice, inflammation and TNF-alpha were markedly reduced when the MTX dosing time was matched to the time (18 HALO) when the TNF-al …
TNF-alpha mRNA levels showed a clear 24-h rhythm with a peak at 22 HALO and a trough at 18 HALO after RA had developed. In these MRL/ …
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
Yukawa E, To H, Ohdo S, Higuchi S, Aoyama T. Yukawa E, et al. Among authors: to h. Eur J Clin Pharmacol. 1998 Mar;54(1):69-74. doi: 10.1007/s002280050423. Eur J Clin Pharmacol. 1998. PMID: 9591934
OBJECTIVE: Nonlinear mixed-effects modeling (NONMEM) was used to estimate the effects of drug drug interaction on phenobarbitone clearance values, using 648 serum levels gathered during the routine clinical care of 349 pediatric and adult epileptic patients (age range, 0.4 …
OBJECTIVE: Nonlinear mixed-effects modeling (NONMEM) was used to estimate the effects of drug drug interaction on phenobarbitone clea …
Change in erythrocyte shape induced by cyclosporine administration.
Ohsako M, To H, Nakamura C, Yamada M, Tsuzuki O, Tatsuo E, Nakashima T, Hirai M, Sasaki H, Ichikawa M, Matsuya F, Saito Y. Ohsako M, et al. Among authors: to h. Biol Pharm Bull. 1998 Nov;21(11):1236-9. doi: 10.1248/bpb.21.1236. Biol Pharm Bull. 1998. PMID: 9853423
Dosing time dependency of doxorubicin-induced cardiotoxicity and bone marrow toxicity in rats.
To H, Ohdo S, Shin M, Uchimaru H, Yukawa E, Higuchi S, Fujimura A, Kobayashi E. To H, et al. J Pharm Pharmacol. 2003 Jun;55(6):803-10. doi: 10.1211/002235703765951410. J Pharm Pharmacol. 2003. PMID: 12841941
When doxorubicin (5 mg kg(-1), i.p.) was administered every seven days (total of 30 mg kg(-1)) at 3, 9, 15 or 21 h after the light was turned on (HALO), toxic death was significantly higher in the 9 HALO treated group than the other groups. ...On day 14, MDA levels increas …
When doxorubicin (5 mg kg(-1), i.p.) was administered every seven days (total of 30 mg kg(-1)) at 3, 9, 15 or 21 h after the light wa …
Influence of dosing schedule on toxicity and antitumor effects of a combination of adriamycin and docetaxel in mice.
To H, Shin M, Tabuchi M, Sakaguchi H, Takeuchi A, Matsunaga N, Higuchi S, Ohdo S. To H, et al. Clin Cancer Res. 2004 Jan 15;10(2):762-9. doi: 10.1158/1078-0432.ccr-1000-03. Clin Cancer Res. 2004. PMID: 14760099
PURPOSE: Although the combination of Adriamycin (ADR) and docetaxel (DOC) showed a better cure rate against metastatic breast cancer in a clinical study, severe myelosuppression and cardiotoxicity were dose-limiting factors. The purpose of this study was to establish the m …
PURPOSE: Although the combination of Adriamycin (ADR) and docetaxel (DOC) showed a better cure rate against metastatic breast cancer in a cl …
Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice.
Matsunaga N, Nakamura N, Yoneda N, Qin T, Terazono H, To H, Higuchi S, Ohdo S. Matsunaga N, et al. Among authors: to h. J Pharmacol Exp Ther. 2004 Nov;311(2):594-600. doi: 10.1124/jpet.104.069062. Epub 2004 Jun 17. J Pharmacol Exp Ther. 2004. PMID: 15205452
The influence of feeding schedule on the chronopharmacological aspects of acetaminophen (APAP) was examined in mice housed under 12-h light/dark cycle (lights on from 7:00 AM to 7:00 PM) with food and water ad libitum feeding (ALF) or under repeated time-restricted …
The influence of feeding schedule on the chronopharmacological aspects of acetaminophen (APAP) was examined in mice housed under 12-h …
199 results