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Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.
Kwok AJ, Allcock A, Ferreira RC, Cano-Gamez E, Smee M, Burnham KL, Zurke YX; Emergency Medicine Research Oxford (EMROx); McKechnie S, Mentzer AJ, Monaco C, Udalova IA, Hinds CJ, Todd JA, Davenport EE, Knight JC. Kwok AJ, et al. Among authors: todd ja. Nat Immunol. 2023 May;24(5):767-779. doi: 10.1038/s41590-023-01490-5. Epub 2023 Apr 24. Nat Immunol. 2023. PMID: 37095375
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Pekalski ML, Ferreira RC, Coulson RM, Cutler AJ, Guo H, Smyth DJ, Downes K, Dendrou CA, Castro Dopico X, Esposito L, Coleman G, Stevens HE, Nutland S, Walker NM, Guy C, Dunger DB, Wallace C, Tree TI, Todd JA, Wicker LS. Pekalski ML, et al. Among authors: todd ja. J Immunol. 2013 Mar 15;190(6):2554-66. doi: 10.4049/jimmunol.1202914. Epub 2013 Feb 15. J Immunol. 2013. PMID: 23418630 Free PMC article.
Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.
Downes K, Marcovecchio ML, Clarke P, Cooper JD, Ferreira RC, Howson JM, Jolley J, Nutland S, Stevens HE, Walker NM, Wallace C, Dunger DB, Todd JA. Downes K, et al. Among authors: todd ja. Diabetologia. 2014 Feb;57(2):366-72. doi: 10.1007/s00125-013-3113-8. Epub 2013 Nov 22. Diabetologia. 2014. PMID: 24264051 Free PMC article.
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.
Ferreira RC, Simons HZ, Thompson WS, Rainbow DB, Yang X, Cutler AJ, Oliveira J, Castro Dopico X, Smyth DJ, Savinykh N, Mashar M, Vyse TJ, Dunger DB, Baxendale H, Chandra A, Wallace C, Todd JA, Wicker LS, Pekalski ML. Ferreira RC, et al. Among authors: todd ja. J Autoimmun. 2017 Nov;84:75-86. doi: 10.1016/j.jaut.2017.07.009. Epub 2017 Jul 23. J Autoimmun. 2017. PMID: 28747257 Free PMC article.
Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.
Cutler AJ, Oliveira J, Ferreira RC, Challis B, Walker NM, Caddy S, Lu J, Stevens HE, Smyth DJ, Pekalski ML, Kennet J, Hunter KMD, Goodfellow I, Wicker LS, Todd JA, Waldron-Lynch F. Cutler AJ, et al. Among authors: todd ja. Wellcome Open Res. 2017 Oct 5;2:28. doi: 10.12688/wellcomeopenres.11300.3. eCollection 2017. Wellcome Open Res. 2017. PMID: 28815218 Free PMC article.
535 results