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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Todoric J, et al. Cancer Cell. 2017 Dec 11;32(6):824-839.e8. doi: 10.1016/j.ccell.2017.10.011. Epub 2017 Nov 16. Cancer Cell. 2017. PMID: 29153842 Free PMC article.
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.
Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Li N, et al. Among authors: todoric j. J Clin Invest. 2013 May;123(5):2231-43. doi: 10.1172/JCI64498. Epub 2013 Apr 8. J Clin Invest. 2013. PMID: 23563314 Free PMC article.
Targeting Inflammation in Cancer Prevention and Therapy.
Todoric J, Antonucci L, Karin M. Todoric J, et al. Cancer Prev Res (Phila). 2016 Dec;9(12):895-905. doi: 10.1158/1940-6207.CAPR-16-0209. Epub 2016 Nov 10. Cancer Prev Res (Phila). 2016. PMID: 27913448 Free PMC article. Review.
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. Su H, et al. Among authors: todoric j. Cancer Cell. 2021 May 10;39(5):678-693.e11. doi: 10.1016/j.ccell.2021.02.016. Epub 2021 Mar 18. Cancer Cell. 2021. PMID: 33740421 Free PMC article.
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.
Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. Rosati A, et al. Among authors: todoric j. Nat Commun. 2015 Nov 2;6:8695. doi: 10.1038/ncomms9695. Nat Commun. 2015. PMID: 26522614 Free PMC article.
Fructose stimulated de novo lipogenesis is promoted by inflammation.
Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. Todoric J, et al. Nat Metab. 2020 Oct;2(10):1034-1045. doi: 10.1038/s42255-020-0261-2. Epub 2020 Aug 24. Nat Metab. 2020. PMID: 32839596 Free PMC article.
43 results