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Showing results for toko h_II
Your search for Tokoh_II retrieved no results
Activation mechanisms of monocytes/macrophages in adult-onset Still disease.
Tsuboi H, Segawa S, Yagishita M, Toko H, Honda F, Kitada A, Miki H, Ohyama A, Hagiwara S, Kondo Y, Matsumoto I, Sumida T. Tsuboi H, et al. Among authors: toko h. Front Immunol. 2022 Aug 26;13:953730. doi: 10.3389/fimmu.2022.953730. eCollection 2022. Front Immunol. 2022. PMID: 36090971 Free PMC article. Review.
Regarding the activation mechanisms of monocytes/macrophages in AOSD, in addition to type II interferon (IFN) stimulation, several pathways have recently been identified, such as the pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (D …
Regarding the activation mechanisms of monocytes/macrophages in AOSD, in addition to type II interferon (IFN) stimulation, several pa …
Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys-Dietz Syndromes.
Takeda N, Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H, Komuro I. Takeda N, et al. Among authors: toko h. Int Heart J. 2016 May 25;57(3):271-7. doi: 10.1536/ihj.16-094. Epub 2016 May 13. Int Heart J. 2016. PMID: 27181042 Free article. Review.
However, recent investigations on molecular mechanisms indicate that increased transforming growth factor-beta (TGF-beta) activity plays a crucial role in the pathogenesis of MFS and related disorders, such as Loeys-Dietz syndrome (LDS), which is caused by mutation in TGF-beta si …
However, recent investigations on molecular mechanisms indicate that increased transforming growth factor-beta (TGF-beta) activity plays a c …
Stretch-modulation of second messengers: effects on cardiomyocyte ion transport.
Kudoh S, Akazawa H, Takano H, Zou Y, Toko H, Nagai T, Komuro I. Kudoh S, et al. Among authors: toko h. Prog Biophys Mol Biol. 2003 May-Jul;82(1-3):57-66. doi: 10.1016/s0079-6107(03)00005-1. Prog Biophys Mol Biol. 2003. PMID: 12732268 Free article. Review.
Furthermore, stretch increases the activity of calcium-dependent effectors such as calcineurin and calmodulin-dependent kinase II, and inhibitors of calcineurin and calmodulin-dependent kinase II significantly attenuated stretch-induced hypertrophy and BNP expressio …
Furthermore, stretch increases the activity of calcium-dependent effectors such as calcineurin and calmodulin-dependent kinase II, an …
Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy.
Toko H, Oka T, Zou Y, Sakamoto M, Mizukami M, Sano M, Yamamoto R, Sugaya T, Komuro I. Toko H, et al. Hypertens Res. 2002 Jul;25(4):597-603. doi: 10.1291/hypres.25.597. Hypertens Res. 2002. PMID: 12358147 Free article.
Since accumulating evidence suggests that activation of the renin-angiotensin system is involved in the development of various types of cardiovascular remodeling, we examined the role of angiotensin II (Ang II) in DOX-induced cardiotoxicity using Ang II type …
Since accumulating evidence suggests that activation of the renin-angiotensin system is involved in the development of various types of card …
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.
Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Zou Y, et al. Among authors: toko h. Nat Cell Biol. 2004 Jun;6(6):499-506. doi: 10.1038/ncb1137. Epub 2004 May 16. Nat Cell Biol. 2004. PMID: 15146194
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism. Without the involvement of angiotensin II …
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor c …
Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome.
Hara H, Maemura S, Fujiwara T, Takeda N, Ishii S, Yagi H, Suzuki T, Harada M, Toko H, Kanaya T, Ijichi H, Moses HL, Takimoto E, Morita H, Akazawa H, Komuro I. Hara H, et al. Among authors: toko h. PLoS One. 2020 Nov 11;15(11):e0239908. doi: 10.1371/journal.pone.0239908. eCollection 2020. PLoS One. 2020. PMID: 33175881 Free PMC article.
However, little is known about the contribution of myeloid cells to aortic aneurysmal formation. In this study, we ablated the TGF-beta type II receptor gene Tgfbr2 in myeloid cells of Fbn1C1039G/+ MFS mice (Fbn1C1039G/+;LysM-Cre/+;Tgfbr2fl/fl mice, hereinafter called Fbn1 …
However, little is known about the contribution of myeloid cells to aortic aneurysmal formation. In this study, we ablated the TGF-beta type …
Abatacept ameliorates both glandular and extraglandular involvements in patients with Sjogren's syndrome associated with rheumatoid arthritis: Findings from an open-label, multicentre, 1-year, prospective study: The ROSE (Rheumatoid Arthritis with Orencia Trial Toward Sjogren's Syndrome Endocrinopathy) and ROSE II trials.
Tsuboi H, Toko H, Honda F, Abe S, Takahashi H, Yagishita M, Hagiwara S, Ohyama A, Kondo Y, Nakano K, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Fujieda Y, Atsumi T, Suzuki Y, Kawano M, Nishina N, Kaneko Y, Takeuchi T, Kobayashi H, Takei M, Ogasawara M, Tamura N, Takasaki Y, Yokota K, Akiyama Y, Mimura T, Murakami K, Mimori T, Ohshima S, Azuma N, Sano H, Nishiyama S, Matsumoto I, Sumida T. Tsuboi H, et al. Among authors: toko h. Mod Rheumatol. 2023 Jan 3;33(1):160-168. doi: 10.1093/mr/roac011. Mod Rheumatol. 2023. PMID: 35134994
MATERIALS AND METHODS: We performed an open-label, prospective, 1-year, observational multicenter study (ROSE and ROSE II trials). The primary endpoint was the remission rate as measured by SDAI at 52 weeks. ...Adverse events and adherence rates were also analyzed. RESULTS …
MATERIALS AND METHODS: We performed an open-label, prospective, 1-year, observational multicenter study (ROSE and ROSE II trials). Th …
Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium.
Toko H, Zou Y, Minamino T, Masaya M, Harada M, Nagai T, Sugaya T, Terasaki F, Kitaura Y, Komuro I. Toko H, et al. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):664-70. doi: 10.1161/01.ATV.0000122361.63827.ab. Epub 2004 Feb 12. Arterioscler Thromb Vasc Biol. 2004. PMID: 14962948
OBJECTIVE: Angiotensin II is critically involved in left ventricular remodeling after myocardial infarction. Neovascularization has been thought to prevent the development of left ventricular remodeling and deterioration to heart failure. To elucidate the role of angiotens …
OBJECTIVE: Angiotensin II is critically involved in left ventricular remodeling after myocardial infarction. Neovascularization has b …
Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy.
Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. Zhu W, et al. Among authors: toko h. J Biol Chem. 2000 May 19;275(20):15239-45. doi: 10.1074/jbc.275.20.15239. J Biol Chem. 2000. PMID: 10809760 Free article.
Similarly, the beta-MHC promoter was activated by Ca(2+) ionophores and a protein kinase C activator. beta-MHC promoter activation induced by ET-1 was suppressed by pretreatment with the calmodulin inhibitor, W7, the Ca(2+)/calmodulin-dependent kinase II (CaMKII) inhibitor …
Similarly, the beta-MHC promoter was activated by Ca(2+) ionophores and a protein kinase C activator. beta-MHC promoter activation induced b …
Gene expression profile revealed different effects of angiotensin II receptor blockade and angiotensin-converting enzyme inhibitor on heart failure.
Mizukami M, Hasegawa H, Kohro T, Toko H, Kudoh S, Zou Y, Aburatani H, Komuro I. Mizukami M, et al. Among authors: toko h. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S1-6. doi: 10.1097/00005344-200312001-00002. J Cardiovasc Pharmacol. 2003. PMID: 14871019
Although recent clinical studies have indicated that angiotensin II receptor blocker is as effective in treating heart failure as an angiotensin-converting enzyme inhibitor, it is unknown whether their effects are different. ...Gene expression pattern examined by Affymetri …
Although recent clinical studies have indicated that angiotensin II receptor blocker is as effective in treating heart failure as an …
13 results