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Proteomics of Long-Lived Mammals.
Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V. Tombline G, et al. Proteomics. 2020 Mar;20(5-6):e1800416. doi: 10.1002/pmic.201800416. Epub 2020 Jan 9. Proteomics. 2020. PMID: 31737995 Free PMC article. Review.
Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway.
Tombline G, Muharemagić A, White LB, Senior AE. Tombline G, et al. Biochemistry. 2005 Sep 27;44(38):12879-86. doi: 10.1021/bi0509797. Biochemistry. 2005. PMID: 16171403
We found recently that the combined mutation of both "catalytic carboxylate" residues (E552A/E1197A) in mouse P-glycoprotein (Pgp) arrested the protein in an "occluded nucleotide conformation", possibly a stabilized dimer of nucleotide-binding domains (NBDs), that binds MgATP tig …
We found recently that the combined mutation of both "catalytic carboxylate" residues (E552A/E1197A) in mouse P-glycoprotein (Pgp) arrested …
42 results