NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.
He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M.
He F, et al.
J Hepatol. 2020 Jun;72(6):1182-1195. doi: 10.1016/j.jhep.2020.01.023. Epub 2020 Feb 24.
J Hepatol. 2020.
PMID: 32105670
Free PMC article.
RESULTS: Hepatocyte-specific NRF2 activation, due to p62 accumulation or inhibition of KEAP1 binding, led to hepatomegaly associated with enhanced glycogenosis, steatosis and G2/M cell cycle arrest, fostering hyperplasia without cell division. Surprisingly, all manipulatio …
RESULTS: Hepatocyte-specific NRF2 activation, due to p62 accumulation or inhibition of KEAP1 binding, led to hepatomegaly associated with en …