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In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor.
Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa D, Nagashima R, Fukuchi M, Okada T, Toyooka N, Miyata A, Gouda H, Kurihara T. Takasaki I, et al. Among authors: toyooka n. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8. doi: 10.1124/jpet.117.245415. Epub 2018 Jan 23. J Pharmacol Exp Ther. 2018. PMID: 29363578
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.
Mori H, Wada R, Takahara S, Horino Y, Izumi H, Ishimoto T, Yoshida T, Mizuguchi M, Obita T, Gouda H, Hirono S, Toyooka N. Mori H, et al. Among authors: toyooka n. Bioorg Med Chem. 2017 Jul 15;25(14):3736-3745. doi: 10.1016/j.bmc.2017.05.011. Epub 2017 May 11. Bioorg Med Chem. 2017. PMID: 28533113
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.
Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A. Endo S, et al. Among authors: toyooka n. J Med Chem. 2017 Oct 26;60(20):8441-8455. doi: 10.1021/acs.jmedchem.7b00830. Epub 2017 Oct 13. J Med Chem. 2017. PMID: 28976752
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Takahara S, Nakagawa K, Uchiyama T, Yoshida T, Matsumoto K, Kawasumi Y, Mizuguchi M, Obita T, Watanabe Y, Hayakawa D, Gouda H, Mori H, Toyooka N. Takahara S, et al. Among authors: toyooka n. Bioorg Med Chem Lett. 2018 Feb 1;28(3):441-445. doi: 10.1016/j.bmcl.2017.12.021. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29277459
Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice.
Sekiguchi F, Fujita T, Deguchi T, Yamaoka S, Tomochika K, Tsubota M, Ono S, Horaguchi Y, Ichii M, Ichikawa M, Ueno Y, Koike N, Tanino T, Nguyen HD, Okada T, Nishikawa H, Yoshida S, Ohkubo T, Toyooka N, Murata K, Matsuda H, Kawabata A. Sekiguchi F, et al. Among authors: toyooka n. Neuropharmacology. 2018 Aug;138:232-244. doi: 10.1016/j.neuropharm.2018.06.020. Epub 2018 Jun 18. Neuropharmacology. 2018. PMID: 29913186
98 results