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Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis.
McCormack PL. McCormack PL. Drugs. 2012 Mar 26;72(5):585-617. doi: 10.2165/11209070-000000000-00000. Drugs. 2012. PMID: 22397329 Review.
Tranexamic acid (Transamin) is indicated in Japan for use in certain conditions with abnormal bleeding or bleeding tendencies in which local or systemic hyperfibrinolysis is considered to be involved. This article reviews the efficacy and tolerability of t …
Tranexamic acid (Transamin) is indicated in Japan for use in certain conditions with abnormal bleeding or bleeding tendencies …
Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis.
Pabinger I, Fries D, Schöchl H, Streif W, Toller W. Pabinger I, et al. Wien Klin Wochenschr. 2017 May;129(9-10):303-316. doi: 10.1007/s00508-017-1194-y. Epub 2017 Apr 21. Wien Klin Wochenschr. 2017. PMID: 28432428 Free PMC article. Review.
In some cases, excessive and diffuse bleeding is caused by systemic activation of fibrinolysis, i. e. hyperfibrinolysis (HF). Uncontrolled HF is associated with a high mortality. Polytrauma patients and those undergoing surgical procedures involving organs rich in plasmino …
In some cases, excessive and diffuse bleeding is caused by systemic activation of fibrinolysis, i. e. hyperfibrinolysis (HF). Uncontr …
The Role of Tranexamic Acid in the Management of an Acutely Hemorrhaging Patient.
Davis S, Nawab A, van Nispen C, Pourmand A. Davis S, et al. Hosp Pharm. 2021 Aug;56(4):350-358. doi: 10.1177/0018578720906613. Epub 2020 Feb 13. Hosp Pharm. 2021. PMID: 34381274 Free PMC article. Review.
Methods: We searched the PubMed database for relevant articles from 2000 to 2018 for the terms "tranexamic acid," "TXA," "antifibrinolytic," "hyperfibrinolysis," and "coagulopathy." ...Conclusions: Recent studies suggest a mortality benefit with tranexamic …
Methods: We searched the PubMed database for relevant articles from 2000 to 2018 for the terms "tranexamic acid," "TXA," "anti …
Diagnosis and Treatment of Hyperfibrinolysis in Trauma (A European Perspective).
Gall LS, Brohi K, Davenport RA. Gall LS, et al. Semin Thromb Hemost. 2017 Mar;43(2):224-234. doi: 10.1055/s-0036-1598001. Epub 2017 Feb 20. Semin Thromb Hemost. 2017. PMID: 28219084 Review.
Fibrinolysis activation occurs almost universally after severe trauma. Systemic hyperfibrinolysis is a key component of acute traumatic coagulopathy and associated with poor clinical outcomes, although controversy exists over optimal treatment strategies. ...In line …
Fibrinolysis activation occurs almost universally after severe trauma. Systemic hyperfibrinolysis is a key component of acute traumat …
Altered Fibrinolysis during and after Surgery.
Colomina MJ, Méndez E, Sabate A. Colomina MJ, et al. Semin Thromb Hemost. 2021 Jul;47(5):512-519. doi: 10.1055/s-0041-1722971. Epub 2021 Apr 20. Semin Thromb Hemost. 2021. PMID: 33878781 Review.
In addition, an increasing number of patients receive anticoagulants and antiplatelet drugs preoperatively that might influence the response to surgical hemostasis. This review focuses on those situations that may change normal hemostasis and coagulation during surgery, pr …
In addition, an increasing number of patients receive anticoagulants and antiplatelet drugs preoperatively that might influence the response …
Tranexamic Acid Use in Prehospital Uncontrolled Hemorrhage.
Huebner BR, Dorlac WC, Cribari C. Huebner BR, et al. Wilderness Environ Med. 2017 Jun;28(2S):S50-S60. doi: 10.1016/j.wem.2016.12.006. Wilderness Environ Med. 2017. PMID: 28601210 Free PMC article. Review.
The use of tranexamic acid (TXA) in the treatment of trauma patients was relatively unexplored until the landmark Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage-2 (CRASH-2) trial in 2010 demonstrated a reduction in mortality with the …
The use of tranexamic acid (TXA) in the treatment of trauma patients was relatively unexplored until the landmark Clini …
The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis.
Harvin JA, Peirce CA, Mims MM, Hudson JA, Podbielski JM, Wade CE, Holcomb JB, Cotton BA. Harvin JA, et al. J Trauma Acute Care Surg. 2015 May;78(5):905-9; discussion 909-11. doi: 10.1097/TA.0000000000000612. J Trauma Acute Care Surg. 2015. PMID: 25909408 Clinical Trial.
BACKGROUND: In 2011, supported by data from two separate trauma centers, we implemented a protocol to administer tranexamic acid (TXA) in trauma patients with evidence of hyperfibrinolysis (HF) on admission. The purpose of this study was to examine whether th …
BACKGROUND: In 2011, supported by data from two separate trauma centers, we implemented a protocol to administer tranexamic acid …
COVID-19-Associated Hyper-Fibrinolysis: Mechanism and Implementations.
Jacob G, Aharon A, Brenner B. Jacob G, et al. Front Physiol. 2020 Dec 16;11:596057. doi: 10.3389/fphys.2020.596057. eCollection 2020. Front Physiol. 2020. PMID: 33391014 Free PMC article. Review.
In addition, plasmin is involved in the pathophysiology of ARDS in SARS and promotes secretion of cytokine, such as IL-6 and TNF, from activated macrophages. Here, we suggest an out-of-the-box treatment for alleviating fibrinolysis and the ARDS of COVID-19 patients. This p …
In addition, plasmin is involved in the pathophysiology of ARDS in SARS and promotes secretion of cytokine, such as IL-6 and TNF, from activ …
Tranexamic acid in trauma: how should we use it?
Roberts I. Roberts I. J Thromb Haemost. 2015 Jun;13 Suppl 1:S195-9. doi: 10.1111/jth.12878. J Thromb Haemost. 2015. PMID: 26149023 Free article. Review.
Tranexamic acid (TXA) reduces blood loss by inhibiting the enzymatic breakdown of fibrin. ...Limiting its use to the most severely injured or those with a diagnosis of 'hyperfibrinolysis' would result in thousands of avoidable deaths. A clinical trial (CRASH- …
Tranexamic acid (TXA) reduces blood loss by inhibiting the enzymatic breakdown of fibrin. ...Limiting its use to the most seve …
Fibrinolysis and antifibrinolytic treatment in the trauma patient.
Gall LS, Davenport RA. Gall LS, et al. Curr Opin Anaesthesiol. 2018 Apr;31(2):227-233. doi: 10.1097/ACO.0000000000000561. Curr Opin Anaesthesiol. 2018. PMID: 29324486 Review.
This review presents our current understanding of the mechanisms of fibrinolysis in trauma, diagnostic evaluation, and the evidence base for treatment. ...D-dimer and viscoelastic haemostatic assays (rotational thromboelastometry, TEG) remain the best available diag …
This review presents our current understanding of the mechanisms of fibrinolysis in trauma, diagnostic evaluation, and the evidence b …
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