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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 3
2000 3
2001 2
2003 2
2004 2
2005 2
2006 6
2007 2
2008 1
2009 7
2010 3
2011 4
2012 5
2013 4
2014 4
2015 4
2016 4
2017 6
2018 4
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2020 6
2021 10
2022 10
2023 15
2024 3

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105 results

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TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy.
Lewinska A, Adamczyk-Grochala J, Wnuk M. Lewinska A, et al. Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188964. doi: 10.1016/j.bbcan.2023.188964. Epub 2023 Aug 23. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37625528 Free article. Review.
TRDMT1 gene knockout (KO) can sensitize cancer cells of different origin to radiotherapy and chemotherapy. ...TRDMT1 as a novel promising target in anticancer therapy is proposed and discussed....
TRDMT1 gene knockout (KO) can sensitize cancer cells of different origin to radiotherapy and chemotherapy. ...TRDMT1 as a nove …
Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells.
Zabek T, Szmatola T, Adamczyk-Grochala J, Lewinska A, Wnuk M. Zabek T, et al. J Neurooncol. 2023 May;163(1):61-69. doi: 10.1007/s11060-023-04304-8. Epub 2023 May 11. J Neurooncol. 2023. PMID: 37169948 Free PMC article.
PURPOSE: We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. ...Reduced representation bisulfite sequencing (RRBS) was considered to comprehensively evaluate DNA methylome in glioblastoma cells w …
PURPOSE: We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma c …
DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis.
Adamczyk-Grochala J, Bloniarz D, Zielinska K, Lewinska A, Wnuk M. Adamczyk-Grochala J, et al. Apoptosis. 2023 Feb;28(1-2):166-185. doi: 10.1007/s10495-022-01779-0. Epub 2022 Oct 23. Apoptosis. 2023. PMID: 36273376 Free PMC article.
Upon DOX stimulation, DNMT2/TRDMT1 gene knockout impaired PERK activation and modulated NSUN and 5-methylcytosine RNA-based responses and microRNA profiles. ...We conclude that DNMT2/TRDMT1 gene knockout, at least in selected cellular cancer models, affects adaptive …
Upon DOX stimulation, DNMT2/TRDMT1 gene knockout impaired PERK activation and modulated NSUN and 5-methylcytosine RNA-based responses …
TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway.
Li Z, Qi X, Zhang X, Yu L, Gao L, Kong W, Chen W, Dong W, Luo L, Lu D, Zhang L, Ma Y. Li Z, et al. Animal Model Exp Med. 2022 Apr;5(2):172-182. doi: 10.1002/ame2.12221. Animal Model Exp Med. 2022. PMID: 35474613 Free PMC article.
RESULTS: Trdmt1 deletion had no obvious impact on development and growth. Trdmt1 deletion slightly increased the mortality during aging. Our data showed that Trdmt1 strongly responded in LPS-treated rats, and Trdmt1 knockout rats were vulnerable to LPS …
RESULTS: Trdmt1 deletion had no obvious impact on development and growth. Trdmt1 deletion slightly increased the mortality dur …
Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response.
Zhu X, Wang X, Yan W, Yang H, Xiang Y, Lv F, Shi Y, Li HY, Lan L. Zhu X, et al. NAR Cancer. 2021 Mar 22;3(1):zcab010. doi: 10.1093/narcan/zcab010. eCollection 2021 Mar. NAR Cancer. 2021. PMID: 33778494 Free PMC article.
Here, we identified that TRDMT1 is poly-ubiquitinated at K251 by the E3 ligase TRIM28, removing TRDMT1 from DNA damage sites and allowing completion of HR. ...A potent TRDMT1 inhibitor resensitizes TRDMT1-high tumor cells to cisplatin. ...
Here, we identified that TRDMT1 is poly-ubiquitinated at K251 by the E3 ligase TRIM28, removing TRDMT1 from DNA damage sites a …
TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.
Sha C, Chen L, Lin L, Li T, Wei H, Yang M, Gao W, Zhao D, Chen Q, Liu Y, Chen X, Xu W, Li Y, Zhu X. Sha C, et al. Aging (Albany NY). 2021 Jun 8;13(11):15193-15213. doi: 10.18632/aging.203080. Epub 2021 Jun 8. Aging (Albany NY). 2021. PMID: 34100772 Free PMC article.
We found that reactive oxygen species were increased in a H(2)O(2) dose-dependent manner and accompanied by the nuclear shuttling of TRDMT1, increased DNA damage and increased apoptosis of granulosa cells. In addition, reactive oxygen species-induced granulosa cells apopto …
We found that reactive oxygen species were increased in a H(2)O(2) dose-dependent manner and accompanied by the nuclear shuttling of TRDM …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.
Yang H, Wang Y, Xiang Y, Yadav T, Ouyang J, Phoon L, Zhu X, Shi Y, Zou L, Lan L. Yang H, et al. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2116251119. doi: 10.1073/pnas.2116251119. Epub 2022 Mar 15. Proc Natl Acad Sci U S A. 2022. PMID: 35290126 Free PMC article.
Here, we identifiedthat Fragile X mental retardation protein (FMRP) promotes transcription-coupled HRvia its interaction with both the m5C writer TRDMT1 and the m5C eraser ten-eleventranslocation protein 1 (TET1). TRDMT1, FMRP, and TET1 function in a temporalorder a …
Here, we identifiedthat Fragile X mental retardation protein (FMRP) promotes transcription-coupled HRvia its interaction with both the m5C w …
Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution.
Li H, Zhu D, Yang Y, Ma Y, Chen Y, Xue P, Chen J, Qin M, Xu D, Cai C, Cheng H. Li H, et al. RNA Biol. 2023 Jan;20(1):875-892. doi: 10.1080/15476286.2023.2272473. Epub 2023 Nov 15. RNA Biol. 2023. PMID: 37966982 Free PMC article.
RNA methyltransferase DNMT2/TRDMT1 is the most conserved member of the DNMT family from bacteria to plants and mammals. ...Moreover, the classical substrate tRNA for DNMT2/TRDMT1 had a characteristic sequence CUXXCAC in the anticodon loop. ...
RNA methyltransferase DNMT2/TRDMT1 is the most conserved member of the DNMT family from bacteria to plants and mammals. ...Moreover, …
Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation.
Xu S, Xiong J, Wu M, Yang Y, Jiang J, Ni H, Zhao Y, Wang Y. Xu S, et al. Braz J Med Biol Res. 2020 Dec 9;54(2):e9869. doi: 10.1590/1414-431X20209869. eCollection 2020. Braz J Med Biol Res. 2020. PMID: 33331537 Free PMC article.
Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematopoiesis. However, little is known about the function of Trdmt1 in AML cell differentiation. ...These findings revealed an unrecognized …
Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematop …
Restricted tRNA methylation by intermolecular disulfide bonds in DNMT2/TRDMT1.
Li H, Zhu D, Yang Y, Ma Y, Chen Y, Xue P, Chen J, Qin M, Xu D, Cai C, Cheng H. Li H, et al. Int J Biol Macromol. 2023 Aug 12;251:126310. doi: 10.1016/j.ijbiomac.2023.126310. Online ahead of print. Int J Biol Macromol. 2023. PMID: 37579906
Reportedly, DNMT2/TRDMT1 mainly methylates tRNAs at C38 and prevents them from the cleavage under stress. ...Here, we explored the restricted tRNA methylation mechanism by DNMT2/TRDMT1. In the current study, the optimized buffer C at 37 C was the best condition for …
Reportedly, DNMT2/TRDMT1 mainly methylates tRNAs at C38 and prevents them from the cleavage under stress. ...Here, we explored the re …
105 results