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Mu opiate active substances trefentanil and naloxonazine: tritiation at high specific activity.
Ahern DG, Egan JA, Seguin RJ, Filer CN. Ahern DG, et al. Appl Radiat Isot. 2005 Aug;63(2):189-92. doi: 10.1016/j.apradiso.2004.12.012. Appl Radiat Isot. 2005. PMID: 15927477
Methods are presented to synthesize and characterize [propyl-(3)H] trefentanil 3 and [propenyl-(3)H] naloxonazine 6....
Methods are presented to synthesize and characterize [propyl-(3)H] trefentanil 3 and [propenyl-(3)H] naloxonazine 6....
Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil.
Lemmens HJ, Dyck JB, Shafer SL, Stanski DR. Lemmens HJ, et al. Clin Pharmacol Ther. 1994 Sep;56(3):261-71. doi: 10.1038/clpt.1994.136. Clin Pharmacol Ther. 1994. PMID: 7924121 Clinical Trial.
Then, in a crossover fashion in five volunteers, we compared the pharmacokinetics and EEG pharmacodynamics of trefentanil with fentanyl and alfentanil. Finally, we used computer simulations to predict offset of opioid effects of trefentanil, fentanyl, and alfentanil …
Then, in a crossover fashion in five volunteers, we compared the pharmacokinetics and EEG pharmacodynamics of trefentanil with fentan …
Pharmacokinetic-pharmacodynamic relationships for opioids in balanced anaesthesia.
Lemmens HJ. Lemmens HJ. Clin Pharmacokinet. 1995 Oct;29(4):231-42. doi: 10.2165/00003088-199529040-00003. Clin Pharmacokinet. 1995. PMID: 8549025 Review.
The pure mu-receptor opioid agonists fentanyl, sufentanil and alfentanil are commonly used to provide the specific anti-nociceptive component of a balanced anaesthesia technique. Trefentanil and remifentanil are new opioids with a very short duration of action. ...
The pure mu-receptor opioid agonists fentanyl, sufentanil and alfentanil are commonly used to provide the specific anti-nociceptive componen …
Validation of the alfentanil canonical univariate parameter as a measure of opioid effect on the electroencephalogram.
Gambús PL, Gregg KM, Shafer SL. Gambús PL, et al. Anesthesiology. 1995 Oct;83(4):747-56. doi: 10.1097/00000542-199510000-00014. Anesthesiology. 1995. PMID: 7574054 Free article.
METHODS: The CUP was tested on EEG data from prior studies of the effect of five opioids: alfentanil (n = 5), fentanyl (n = 15), sufentanil (n = 11), trefentanil (n = 5), and remifentanil (n = 8). We compared the CUP to the commonly used EEG parameter spectral edge, SE95%. …
METHODS: The CUP was tested on EEG data from prior studies of the effect of five opioids: alfentanil (n = 5), fentanyl (n = 15), sufentanil …
New opioid analgesics: an update.
Minto CF, Power I. Minto CF, et al. Int Anesthesiol Clin. 1997 Spring;35(2):49-65. doi: 10.1097/00004311-199703520-00005. Int Anesthesiol Clin. 1997. PMID: 9246581 Review. No abstract available.