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1,868 results

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TREM2, microglia, and Alzheimer's disease.
Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y. Qin Q, et al. Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28. Mech Ageing Dev. 2021. PMID: 33516818 Review.
Since then, rapidly increasing literature related to TREM2 has focused on elucidating its role in AD pathology. In this review, we summarize our understanding of TREM2 biology, explore TREM2 functions in microglia, address the multiple mechanisms of TREM2 …
Since then, rapidly increasing literature related to TREM2 has focused on elucidating its role in AD pathology. In this review, we su …
TREM2(hi) resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis.
Zhang K, Wang Y, Chen S, Mao J, Jin Y, Ye H, Zhang Y, Liu X, Gong C, Cheng X, Huang X, Hoeft A, Chen Q, Li X, Fang X. Zhang K, et al. Nat Metab. 2023 Jan;5(1):129-146. doi: 10.1038/s42255-022-00715-5. Epub 2023 Jan 12. Nat Metab. 2023. PMID: 36635449 Free PMC article.
By combining single-cell RNA sequencing with fate mapping in a mouse model of sepsis, we demonstrate that the Mac1 subpopulation has distinct transcriptomic signatures enriched in endocytosis and displays high expression of TREM2 (TREM2(hi)). TREM2(hi) Mac1 c …
By combining single-cell RNA sequencing with fate mapping in a mouse model of sepsis, we demonstrate that the Mac1 subpopulation has distinc …
TREM2(+) macrophages suppress CD8(+) T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma.
Tan J, Fan W, Liu T, Zhu B, Liu Y, Wang S, Wu J, Liu J, Zou F, Wei J, Liu L, Zhang X, Zhuang J, Wang Y, Lin H, Huang X, Chen S, Kuang M, Li J. Tan J, et al. J Hepatol. 2023 Jul;79(1):126-140. doi: 10.1016/j.jhep.2023.02.032. Epub 2023 Mar 6. J Hepatol. 2023. PMID: 36889359
TREM2(+) TAMs secreted less CXCL9 but more galectin-1 than did TREM2(-) TAMs. ...Mechanistically, TREM2(+) TAMs display lower CXCL9 and increased Gal-1 secretion than do TREM2(-) TAMs, with Gal-1 mediating the overexpression of PD-L1 in vessel endothel …
TREM2(+) TAMs secreted less CXCL9 but more galectin-1 than did TREM2(-) TAMs. ...Mechanistically, TREM2(+) TAMs display …
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.
Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF. Zhong L, et al. Immunity. 2023 Aug 8;56(8):1794-1808.e8. doi: 10.1016/j.immuni.2023.06.016. Epub 2023 Jul 12. Immunity. 2023. PMID: 37442133
Administration of a 41-amino-acid TREM2 peptide, which we identified to be responsible for TREM2 binding to C1q, rescued synaptic impairments in AD mouse models. We thus demonstrate a critical role for microglial TREM2 in restricting complement-mediated synap …
Administration of a 41-amino-acid TREM2 peptide, which we identified to be responsible for TREM2 binding to C1q, rescued synap …
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M. Ulland TK, et al. Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023. Cell. 2017. PMID: 28802038 Free PMC article.
How TREM2 promotes such diverse responses is unknown. Here, we find that microglia in AD patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under gr …
How TREM2 promotes such diverse responses is unknown. Here, we find that microglia in AD patients carrying TREM2 risk variants …
TREM2: A new player in the tumor microenvironment.
Molgora M, Liu YA, Colonna M, Cella M. Molgora M, et al. Semin Immunol. 2023 May;67:101739. doi: 10.1016/j.smim.2023.101739. Epub 2023 Mar 28. Semin Immunol. 2023. PMID: 36989543 Review.
Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. ...
Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protecti …
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G. Nugent AA, et al. Neuron. 2020 Mar 4;105(5):837-854.e9. doi: 10.1016/j.neuron.2019.12.007. Epub 2020 Jan 2. Neuron. 2020. PMID: 31902528 Free article.
TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. ...Our studies identify TREM2 as a key transcriptional regulator of cholesterol transport and metabolism under conditions of chronic myelin phagocytic activ …
TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. ...Our studies identify …
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insights into TREM2 functions in amyloid plaque maintenance, microglial envelopment of plaque, microglia viability, and the …
Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, prov …
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M. Wang S, et al. J Exp Med. 2020 Sep 7;217(9):e20200785. doi: 10.1084/jem.20200785. J Exp Med. 2020. PMID: 32579671 Free PMC article. Clinical Trial.
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. ...Thus, AD may benefit from TREM2 activation. Here, we examined the impact of an anti-human TREM2 …
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Al …
TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function.
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H. Zhao Y, et al. Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031. Neuron. 2018. PMID: 29518356 Free PMC article.
Neurobiological functions of TREM2 and its pathophysiological ligands remain elusive. Here we found that TREM2 directly binds to beta-amyloid (Abeta) oligomers with nanomolar affinity, whereas AD-associated TREM2 mutations reduce Abeta binding. TREM2 d …
Neurobiological functions of TREM2 and its pathophysiological ligands remain elusive. Here we found that TREM2 directly binds …
1,868 results