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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 1
2005 1
2006 3
2007 2
2008 2
2009 2
2010 2
2012 4
2013 3
2014 3
2015 2
2016 4
2017 1
2018 9
2019 6
2020 4
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2023 6
2024 3

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56 results

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Page 1
Large-scale rare variant burden testing in Parkinson's disease.
Makarious MB, Lake J, Pitz V, Ye Fu A, Guidubaldi JL, Solsberg CW, Bandres-Ciga S, Leonard HL, Kim JJ, Billingsley KJ, Grenn FP, Jerez PA, Alvarado CX, Iwaki H, Ta M, Vitale D, Hernandez D, Torkamani A, Ryten M, Hardy J; UK Brain Expression Consortium (UKBEC),; Scholz SW, Traynor BJ, Dalgard CL, Ehrlich DJ, Tanaka T, Ferrucci L, Beach TG, Serrano GE, Real R, Morris HR, Ding J, Gibbs JR, Singleton AB, Nalls MA, Bhangale T, Blauwendraat C. Makarious MB, et al. Brain. 2023 Nov 2;146(11):4622-4632. doi: 10.1093/brain/awad214. Brain. 2023. PMID: 37348876 Free PMC article.
We identify potential novel risk associations for variants in B3GNT3, AUNIP, ADH5, TUBA1B, OR1G1, CAPN10 and TREML1 but were unable to replicate the observed associations across independent datasets. Of these, B3GNT3 and TREML1 could provide new evidence for the rol …
We identify potential novel risk associations for variants in B3GNT3, AUNIP, ADH5, TUBA1B, OR1G1, CAPN10 and TREML1 but were unable t …
Platelet biology of the rapidly failing lung.
Washington AV, Esponda O, Gibson A. Washington AV, et al. Br J Haematol. 2020 Mar;188(5):641-651. doi: 10.1111/bjh.16315. Epub 2019 Nov 7. Br J Haematol. 2020. PMID: 31696941 Free PMC article. Review.
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.
Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, Lincoln S, Malphrus KG, Morgan K, Golde TE, Price ND, White CC, De Jager PL, Bennett DA, Asmann YW, Crook JE, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Carrasquillo MM, et al. Alzheimers Dement. 2017 Jun;13(6):663-673. doi: 10.1016/j.jalz.2016.10.005. Epub 2016 Dec 8. Alzheimers Dement. 2017. PMID: 27939925 Free PMC article.
RESULTS: A variant within a DNase hypersensitive site 5' of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6.3 10(-3) and 4.6 10(-2), respectively). ...DISCUSSION: Our findings point to rs9357347 as a functional r …
RESULTS: A variant within a DNase hypersensitive site 5' of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 …
Who is who within the universe of TREM-like transcripts (TREML)?
Ertel MV, da Silva ABA, de Sousa DF, Dos Santos CJ, da Silva TM, da Silva-Sales MFM, de Oliveira Matos A, Sales-Campos H. Ertel MV, et al. Life Sci. 2024 May 4;348:122696. doi: 10.1016/j.lfs.2024.122696. Online ahead of print. Life Sci. 2024. PMID: 38710279 Review.
However, the same is not observed for the other family members collectively known as TREM-like-transcripts (TREML). The TREML family consists of eight receptors, with TREML1-5 identified in humans and mice, TREML-6 exclusive found in mice, TREML-7 in dogs and horses, and T …
However, the same is not observed for the other family members collectively known as TREM-like-transcripts (TREML). The TREML family consist …
Clinical application of sepsis biomarkers.
Sankar V, Webster NR. Sankar V, et al. J Anesth. 2013 Apr;27(2):269-83. doi: 10.1007/s00540-012-1502-7. Epub 2012 Oct 30. J Anesth. 2013. PMID: 23108494 Review.
Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.
Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE; Alzheimer's Disease Neuroimaging Initiative (ADNI); Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL; Alzheimer's Disease Sequencing Project (ADSP). Wang Y, et al. Alzheimers Dement. 2024 May;20(5):3290-3304. doi: 10.1002/alz.13705. Epub 2024 Mar 21. Alzheimers Dement. 2024. PMID: 38511601 Free PMC article.
RESULTS: Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4. KAT8 was implicated by both single variant and rare variant aggregate analyses. ...
RESULTS: Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1 …
Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Kang SS, Kurti A, Baker KE, Liu CC, Colonna M, Ulrich JD, Holtzman DM, Bu G, Fryer JD. Kang SS, et al. Hum Mol Genet. 2018 Jan 15;27(2):211-223. doi: 10.1093/hmg/ddx366. Hum Mol Genet. 2018. PMID: 29040522 Free PMC article.
Importantly, our transcriptome analysis revealed that our Trem2-/- mouse line (Velocigene allele) results in exaggerated Treml1 upregulation. In contrast, aberrantly high Treml1 expression was absent in the Trem2 knockout line generated by the Colonna lab and the Ja …
Importantly, our transcriptome analysis revealed that our Trem2-/- mouse line (Velocigene allele) results in exaggerated Treml1 upreg …
Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases.
Pelham CJ, Agrawal DK. Pelham CJ, et al. Expert Rev Clin Immunol. 2014 Feb;10(2):243-56. doi: 10.1586/1744666X.2014.866519. Epub 2013 Dec 10. Expert Rev Clin Immunol. 2014. PMID: 24325404 Review.
TREM-1- and TREM-2-dependent signaling, as opposed to TREM-like transcript-1 (TLT-1 or TREML1), are mediated through association with the transmembrane adaptor DNAX activation protein of 12 kDa (DAP12). ...
TREM-1- and TREM-2-dependent signaling, as opposed to TREM-like transcript-1 (TLT-1 or TREML1), are mediated through association with …
TLT-1-CONTROLS EARLY THROMBUS FORMATION AND STABILITY BY FACILITATING AIIBB3 OUTSIDE-IN SIGNALING IN MICE.
Jessica MO, Fiorella R, Ocatavio S, Linnette R, Nahomy L, Kanth MB, Bismarck M, Rondina MT, Valance WA. Jessica MO, et al. Int J Adv Res (Indore). 2018 Mar;6(3):1143-1149. doi: 10.21474/IJAR01/7469. Epub 2018 Jul 27. Int J Adv Res (Indore). 2018. PMID: 30931337 Free PMC article.
To define a role for TLT-1 in immune derived bleeding we used a CXCL-2 mediated local inflammatory reaction in the vessels of the cremaster muscle of treml1 (-/-) and wild type mice. Our whole mount immunofluorescent staining of the cremaster muscle demonstrated a 50% redu …
To define a role for TLT-1 in immune derived bleeding we used a CXCL-2 mediated local inflammatory reaction in the vessels of the cremaster …
Aberrantly expressed long noncoding RNAs and genes in Parkinson's disease.
Zhou Y, Gu C, Li J, Zhu L, Huang G, Dai J, Huang H. Zhou Y, et al. Neuropsychiatr Dis Treat. 2018 Nov 22;14:3219-3229. doi: 10.2147/NDT.S178435. eCollection 2018. Neuropsychiatr Dis Treat. 2018. PMID: 30538480 Free PMC article.
ERBB2, HSPB1, and MYC were three hub proteins of PD-specific protein-protein interaction network. LOC105378701-TAL1, LOC102724104-CX3CR1, LOC105375056-TREML1/TREML4, LOC105379392-ANK1, and LOC101928100-KLRK1/KLRD1 interactions were identified DElncRNA nearby targeted DEmRN …
ERBB2, HSPB1, and MYC were three hub proteins of PD-specific protein-protein interaction network. LOC105378701-TAL1, LOC102724104-CX3CR1, LO …
56 results