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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
2003 4
2004 1
2005 8
2006 8
2007 13
2008 17
2009 22
2010 25
2011 26
2012 23
2013 31
2014 24
2015 43
2016 33
2017 38
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2023 42
2024 22

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539 results

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Page 1
TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer.
Shang S, Yang YW, Chen F, Yu L, Shen SH, Li K, Cui B, Lv XX, Zhang C, Yang C, Liu J, Yu JJ, Zhang XW, Li PP, Zhu ST, Zhang HZ, Hua F. Shang S, et al. Sci Transl Med. 2022 Jan 5;14(626):eabf0992. doi: 10.1126/scitranslmed.abf0992. Epub 2022 Jan 5. Sci Transl Med. 2022. PMID: 34985967
We showed that TRIB3 was acetylated by acetyltransferase P300, which inhibited ubiquitination and subsequent proteasomal degradation of TRIB3. ...Genetic ablation of Trib3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor incre …
We showed that TRIB3 was acetylated by acetyltransferase P300, which inhibited ubiquitination and subsequent proteasomal degradation …
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation.
Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW. Zhang XW, et al. Autophagy. 2020 May;16(5):782-796. doi: 10.1080/15548627.2019.1635383. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286822 Free PMC article.
Human fibrotic liver tissues expressed higher levels of TRIB3 and selective autophagic receptor SQSTM1/p62 (sequestosome 1) than nonfibrotic tissues and the elevated expression of TRIB3 and SQSTM1 was positively correlated in the fibrotic tissues. Silencing Trib3 …
Human fibrotic liver tissues expressed higher levels of TRIB3 and selective autophagic receptor SQSTM1/p62 (sequestosome 1) than nonf …
TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4alpha stability.
Xiao MC, Jiang N, Chen LL, Liu F, Liu SQ, Ding CH, Wu SH, Wang KQ, Luo YY, Peng Y, Yan FZ, Zhang X, Qian H, Xie WF. Xiao MC, et al. J Hepatol. 2024 May;80(5):778-791. doi: 10.1016/j.jhep.2023.12.029. Epub 2024 Jan 17. J Hepatol. 2024. PMID: 38237865
RESULTS: TRIB3 directly interacts with HNF4alpha and mediates ER stress-induced HNF4alpha degradation. ...Inhibiting the TRIB3-HNF4alpha interaction effectively stabilized HNF4alpha protein levels and transcription factor activity in the liver and ameliorated TRI …
RESULTS: TRIB3 directly interacts with HNF4alpha and mediates ER stress-induced HNF4alpha degradation. ...Inhibiting the TRIB3 …
TRIB3 Interacts With beta-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis.
Hua F, Shang S, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW. Hua F, et al. Gastroenterology. 2019 Feb;156(3):708-721.e15. doi: 10.1053/j.gastro.2018.10.031. Epub 2018 Oct 24. Gastroenterology. 2019. PMID: 30365932
TRIB3 overexpression increased, and TRIB3 knockdown decreased, recruitment of TCF4 and beta-catenin to the promoter region of genes regulated by Wnt. ...Strategies to block TRIB3 activity might be developed for treatment of CRC....
TRIB3 overexpression increased, and TRIB3 knockdown decreased, recruitment of TCF4 and beta-catenin to the promoter region of …
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription.
Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K, Lv XX, Zhang XW, Liu YY, Yu JJ, Liu SS, Shang S, Wang F, Yang ZN, Zhao CX, Hou XY, Li PP, Huang B, Cui B, Hu ZW. Yu JM, et al. Nat Commun. 2019 Dec 16;10(1):5720. doi: 10.1038/s41467-019-13700-6. Nat Commun. 2019. PMID: 31844113 Free PMC article.
Here we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression. ...Our study provides insights into breast cancer development and confers a potential therapeutic strategy against TRIB3-overexpre …
Here we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progressio …
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target.
Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW. Yu JJ, et al. Nat Commun. 2020 Jul 21;11(1):3660. doi: 10.1038/s41467-020-17385-0. Nat Commun. 2020. PMID: 32694521 Free PMC article.
TRIB3 interacts with EGFR and recruits PKCalpha to induce a Thr654 phosphorylation and WWP1-induced Lys689 ubiquitination in the EGFR juxtamembrane region, which enhances EGFR recycling, stability, downstream activity, and NSCLC stemness. Disturbing the TRIB3-EGFR i …
TRIB3 interacts with EGFR and recruits PKCalpha to induce a Thr654 phosphorylation and WWP1-induced Lys689 ubiquitination in the EGFR …
TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2.
Lv X, Liu S, Liu C, Li Y, Zhang T, Qi J, Li K, Hua F, Cui B, Zhang X, Liu Y, Yu J, Yu J, Li L, Li X, Yao Z, Huang B. Lv X, et al. Acta Pharm Sin B. 2023 Apr;13(4):1631-1647. doi: 10.1016/j.apsb.2023.01.008. Epub 2023 Jan 11. Acta Pharm Sin B. 2023. PMID: 37139431 Free PMC article.
Targeting SLUG degradation by disturbing the TRIB3/MDM2 interaction using a new synthetic staple peptide restores LAR capacity and exhibits potent therapeutic efficacy against experimental PF. Our study reveals a mechanism of the TRIB3-MDM2-SLUG-SLC34A2 axis causing …
Targeting SLUG degradation by disturbing the TRIB3/MDM2 interaction using a new synthetic staple peptide restores LAR capacity and ex …
TRIB3 Interacts with STAT3 to Promote Cancer Angiogenesis.
Chen QZ, Chen Y, Li X, Liu H, Sun XL. Chen QZ, et al. Curr Med Sci. 2022 Oct;42(5):932-940. doi: 10.1007/s11596-022-2655-8. Epub 2022 Oct 17. Curr Med Sci. 2022. PMID: 36245025
RESULTS: TRIB3 was increased in colon cancer tissues compared to normal tissues, and elevated TRIB3 expression indicated a poor prognosis in colon cancer patients. Moreover, it was found that silencing TRIB3 could inhibit cancer angiogenesis, whereas overexpr …
RESULTS: TRIB3 was increased in colon cancer tissues compared to normal tissues, and elevated TRIB3 expression indicated a poo …
TRIB3-Regulated Akt Signal Pathway Affects Trophoblast Invasion in the Development of Preeclampsia.
Sui X, Zhang L, Zhang XF, Zhang Y. Sui X, et al. Am J Perinatol. 2023 Sep;40(12):1359-1366. doi: 10.1055/s-0041-1735872. Epub 2021 Sep 22. Am J Perinatol. 2023. PMID: 34553361
RESULTS: The placenta of PE patients presented with increased TRIB3 expression. In comparison with Mock group, the proliferation, invasion, and migration of HTR-8/SVneo and JEG-3 cells in TRIB3 siRNA-1 group and TRIB3 siRNA-2 group increased, with decreased …
RESULTS: The placenta of PE patients presented with increased TRIB3 expression. In comparison with Mock group, the proliferation, inv …
Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer.
Mondal D, Mathur A, Chandra PK. Mondal D, et al. Biochimie. 2016 May;124:34-52. doi: 10.1016/j.biochi.2016.02.005. Epub 2016 Feb 6. Biochimie. 2016. PMID: 26855171 Review.
The MEK1 binding domain of TRIB3 enables it to deactivate multiple MAP-kinases. In addition, the COP1 motif of TRIB3 assists ubiquitination and proteasomal degradation of numerous TRIB3 associated proteins. The most well studied action of TRIB3 has bee …
The MEK1 binding domain of TRIB3 enables it to deactivate multiple MAP-kinases. In addition, the COP1 motif of TRIB3 assists u …
539 results