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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 3
1948 6
1949 7
1950 4
1951 9
1952 24
1953 59
1954 78
1955 487
1956 544
1957 346
1958 331
1959 316
1960 334
1961 394
1962 434
1963 603
1964 766
1965 595
1966 667
1967 817
1968 978
1969 924
1970 994
1971 1116
1972 1211
1973 1284
1974 1535
1975 1458
1976 1454
1977 1384
1978 1419
1979 1454
1980 1417
1981 1479
1982 1609
1983 1513
1984 1650
1985 1923
1986 1915
1987 1791
1988 1758
1989 1806
1990 1942
1991 1953
1992 2110
1993 1976
1994 1932
1995 1922
1996 1988
1997 2024
1998 2049
1999 2022
2000 1995
2001 2077
2002 1991
2003 1990
2004 1966
2005 2148
2006 2245
2007 2284
2008 2281
2009 2130
2010 2206
2011 2157
2012 2180
2013 2225
2014 2218
2015 2158
2016 2144
2017 2016
2018 2079
2019 2171
2020 2354
2021 2373
2022 2809
2023 2532
2024 1006

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106,231 results

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Page 1
The Role of Phyto-Melatonin and Related Metabolites in Response to Stress.
Yu Y, Lv Y, Shi Y, Li T, Chen Y, Zhao D, Zhao Z. Yu Y, et al. Molecules. 2018 Jul 28;23(8):1887. doi: 10.3390/molecules23081887. Molecules. 2018. PMID: 30060559 Free PMC article. Review.
Beginning from the precursor tryptophan, four consecutive enzymes mediate the biosynthesis of tryptamine or 5-hydroxytryptophan, serotonin, N-acetylserotonin or 5-methoxytryptamine, and melatonin. ...
Beginning from the precursor tryptophan, four consecutive enzymes mediate the biosynthesis of tryptamine or 5-hydroxytryptophan, sero …
Tryptamine: A privileged scaffold for the management of Alzheimer's disease.
Singh YP, Kumar H. Singh YP, et al. Drug Dev Res. 2023 Dec;84(8):1578-1594. doi: 10.1002/ddr.22111. Epub 2023 Sep 7. Drug Dev Res. 2023. PMID: 37675624 Review.
., memantine), and the recently approved Abeta modulator (e.g., aducanumab). Tryptamine (2-(1H-indol-3-yl)ethan-1-amine) is a small molecule that contains an indole nucleus and an ethylamine side chain. ...It possesses a wide range of biological activities related to neuro …
., memantine), and the recently approved Abeta modulator (e.g., aducanumab). Tryptamine (2-(1H-indol-3-yl)ethan-1-amine) is a small m …
Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders.
Mousseau DD. Mousseau DD. Metab Brain Dis. 1993 Mar;8(1):1-44. doi: 10.1007/BF01000528. Metab Brain Dis. 1993. PMID: 8098507 Review.
Although early interest in the biomedical relevance of tryptamine has waned in recent years, it is clear from the above discussion that the study of tryptamine is worthy of serious consideration as a factor in neuropsychiatric disorders. The study of [3H]-tryptam …
Although early interest in the biomedical relevance of tryptamine has waned in recent years, it is clear from the above discussion th …
Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin.
Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D. Fricke J, et al. Chemistry. 2020 Jul 2;26(37):8281-8285. doi: 10.1002/chem.202000134. Epub 2020 Jun 8. Chemistry. 2020. PMID: 32101345 Free PMC article.
We also describe a pilot-scale protocol for recombinant PsiK that yielded 150 mg enzyme in active and soluble form. Our work consolidates the simplicity of tryptamine chemistry with the specificity and selectivity of enzymatic catalysis and helps provide access to an impor …
We also describe a pilot-scale protocol for recombinant PsiK that yielded 150 mg enzyme in active and soluble form. Our work consolidates th …
Formation of a beta-carboline (1,2,3,4-tetrahydro-1-methyl-beta-carboline-1-carboxylic acid) following intracerebroventricular injection of tryptamine and pyruvic acid.
Susilo R, Rommelspacher H. Susilo R, et al. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):70-6. doi: 10.1007/BF00165039. Naunyn Schmiedebergs Arch Pharmacol. 1987. PMID: 3574494
Five minutes following the i.c.v. injection, approximately 0.45% of the administered tryptamine was converted into 1-CTHH and 23% were still unchanged. The amount of the radioactive 1-CTHH increased slightly within 1 h (0.8%; [3H] tryptamine: 6%). ...To support the …
Five minutes following the i.c.v. injection, approximately 0.45% of the administered tryptamine was converted into 1-CTHH and 23% wer …
5-benzyloxytryptamine as an antagonist of TRPM8.
DeFalco J, Steiger D, Dourado M, Emerling D, Duncton MA. DeFalco J, et al. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. doi: 10.1016/j.bmcl.2010.09.099. Epub 2010 Sep 22. Bioorg Med Chem Lett. 2010. PMID: 20965726
For example, 19 had an IC(50) of 0.34 muM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity at TRPM8. ...
For example, 19 had an IC(50) of 0.34 muM when menthol was used as the stimulating agonist. Related commercially-available tryptamine …
Ruthenium Catalyzed Tandem Pictet-Spengler Reaction.
Nalikezhathu A, Cherepakhin V, Williams TJ. Nalikezhathu A, et al. Org Lett. 2020 Jul 2;22(13):4979-4984. doi: 10.1021/acs.orglett.0c01485. Epub 2020 Jun 19. Org Lett. 2020. PMID: 32558575
We report a pyridyl-phosphine ruthenium(II) catalyzed tandem alcohol amination/Pictet-Spengler reaction sequence to synthesize tetrahydro-beta-carbolines from an alcohol and tryptamine. Our conditions use a Lewis acid cocatalyst, In(OTf)(3), that is compatible with typical …
We report a pyridyl-phosphine ruthenium(II) catalyzed tandem alcohol amination/Pictet-Spengler reaction sequence to synthesize tetrahydro-be …
Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?
Jones RS. Jones RS. Prog Neurobiol. 1982;19(1-2):117-39. doi: 10.1016/0301-0082(82)90023-5. Prog Neurobiol. 1982. PMID: 6131482
Neuropharmacological and electrophysiological data strongly suggest the existence of post-synaptic receptors for tryptamine independent of those for 5HT. There may exist a rostrally projecting neuronal tryptamine containing system arising from cell bodies in or clos …
Neuropharmacological and electrophysiological data strongly suggest the existence of post-synaptic receptors for tryptamine independe …
Tryptamine, a Microbial Metabolite in Fermented Rice Bran Suppressed Lipopolysaccharide-Induced Inflammation in a Murine Macrophage Model.
Agista AZ, Tanuseputero SA, Koseki T, Ardiansyah, Budijanto S, Sultana H, Ohsaki Y, Yeh CL, Yang SC, Komai M, Shirakawa H. Agista AZ, et al. Int J Mol Sci. 2022 Sep 23;23(19):11209. doi: 10.3390/ijms231911209. Int J Mol Sci. 2022. PMID: 36232510 Free PMC article.
These results indicate that tryptamine may play an important role in the anti-inflammatory effects of fermented rice bran. Furthermore, the anti-inflammatory effects of FRBE and tryptamine may depend on the activity of the aryl hydrocarbon receptor....
These results indicate that tryptamine may play an important role in the anti-inflammatory effects of fermented rice bran. Furthermor …
Pharmacology of harmalan (1-methyl-3,4-dihydro-beta-carboline).
Rommelspacher H, Brüning G, Susilo R, Nick M, Hill R. Rommelspacher H, et al. Eur J Pharmacol. 1985 Mar 12;109(3):363-71. doi: 10.1016/0014-2999(85)90397-8. Eur J Pharmacol. 1985. PMID: 2580722
Receptor binding experiments as well as combined treatments with antagonists point to an interaction which involves neither benzodiazepine nor 5HT2 receptor sites but rather tryptamine binding sites. Good agreement was found between the potency of harmalan to increase spon …
Receptor binding experiments as well as combined treatments with antagonists point to an interaction which involves neither benzodiazepine n …
106,231 results
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