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The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.
Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. Tizzano JP, et al. Among authors: tschop mh. J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. doi: 10.1124/jpet.107.133132. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089843
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C. Nogueiras R, et al. Endocrinology. 2007 Jan;148(1):21-6. doi: 10.1210/en.2006-0915. Epub 2006 Sep 28. Endocrinology. 2007. PMID: 17008393
A sweet spot for the bariatric surgeon.
Perez-Tilve D, D'Alessio DA, Tschöp MH. Perez-Tilve D, et al. Among authors: tschop mh. Cell Metab. 2008 Sep;8(3):177-9. doi: 10.1016/j.cmet.2008.08.012. Cell Metab. 2008. PMID: 18762016 Free article.
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.
Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: tschop mh. J Neurosci. 2009 May 6;29(18):5916-25. doi: 10.1523/JNEUROSCI.5977-08.2009. J Neurosci. 2009. PMID: 19420258 Free PMC article.
Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system.
Pérez-Tilve D, González-Matías L, Aulinger BA, Alvarez-Crespo M, Gil-Lozano M, Alvarez E, Andrade-Olivie AM, Tschöp MH, D'Alessio DA, Mallo F. Pérez-Tilve D, et al. Among authors: tschop mh. Am J Physiol Endocrinol Metab. 2010 May;298(5):E1088-96. doi: 10.1152/ajpendo.00464.2009. Epub 2010 Mar 2. Am J Physiol Endocrinol Metab. 2010. PMID: 20197503 Free PMC article.
Action profile of the antiobesity drug candidate oleoyl-estrone in rats.
Strassburg S, Pfluger PT, Chaudhary N, Tso P, Tschöp MH, Anker SD, Nogueiras R, Perez-Tilve D. Strassburg S, et al. Among authors: tschop mh. Obesity (Silver Spring). 2010 Dec;18(12):2260-7. doi: 10.1038/oby.2010.53. Epub 2010 Mar 25. Obesity (Silver Spring). 2010. PMID: 20339368 Free article.
431 results