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Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload.
Kishimoto H, Iwasaki M, Wada K, Horitani K, Tsukamoto O, Kamikubo K, Nomura S, Matsumoto S, Harada T, Motooka D, Okuzaki D, Takashima S, Komuro I, Kikuchi A, Shiojima I. Kishimoto H, et al. Among authors: tsukamoto o. iScience. 2023 Jun 15;26(7):107146. doi: 10.1016/j.isci.2023.107146. eCollection 2023 Jul 21. iScience. 2023. PMID: 37456848 Free PMC article.
Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin.
Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, Higo S, Ogawa S, Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin J, Ueda K, Segawa T, Nishimura S, Asano Y, Asanuma H, Tani A, Imamura R, Komagawa S, Kanai T, Takamura M, Sakata Y, Kitakaze M, Haruta JI, Takashima S. Hitsumoto T, et al. Among authors: tsukamoto o. Circulation. 2023 Jun 20;147(25):1902-1918. doi: 10.1161/CIRCULATIONAHA.122.062885. Epub 2023 May 2. Circulation. 2023. PMID: 37128901 Free PMC article.
Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.
Hakui H, Kioka H, Miyashita Y, Nishimura S, Matsuoka K, Kato H, Tsukamoto O, Kuramoto Y, Takuwa A, Takahashi Y, Saito S, Ohta K, Asanuma H, Fu HY, Shinomiya H, Yamada N, Ohtani T, Sawa Y, Kitakaze M, Takashima S, Sakata Y, Asano Y. Hakui H, et al. Among authors: tsukamoto o. Sci Transl Med. 2022 Jan 19;14(628):eabf3274. doi: 10.1126/scitranslmed.abf3274. Epub 2022 Jan 19. Sci Transl Med. 2022. PMID: 35044787
74 results