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1993 2
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2003 5
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2007 26
2008 22
2009 51
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965 results

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TUBB3 and KIF21A in neurodevelopment and disease.
Puri D, Barry BJ, Engle EC. Puri D, et al. Front Neurosci. 2023 Aug 4;17:1226181. doi: 10.3389/fnins.2023.1226181. eCollection 2023. Front Neurosci. 2023. PMID: 37600020 Free PMC article. Review.
Neuronal migration and axon growth and guidance require precise control of microtubule dynamics and microtubule-based cargo transport. TUBB3 encodes the neuronal-specific beta-tubulin isotype III, TUBB3, a component of neuronal microtubules expressed throughout the …
Neuronal migration and axon growth and guidance require precise control of microtubule dynamics and microtubule-based cargo transport. TU …
TUBB3 M323V Syndrome Presents with Infantile Nystagmus.
Jin S, Park SE, Won D, Lee ST, Han SH, Han J. Jin S, et al. Genes (Basel). 2021 Apr 15;12(4):575. doi: 10.3390/genes12040575. Genes (Basel). 2021. PMID: 33921132 Free PMC article. Review.
Variants in the TUBB3 gene, one of the tubulin-encoding genes, are known to cause congenital fibrosis of the extraocular muscles type 3 and/or malformations of cortical development. Herein, we report a case of a 6-month-old infant with c.967A>G:p.(M323V) variant in the …
Variants in the TUBB3 gene, one of the tubulin-encoding genes, are known to cause congenital fibrosis of the extraocular muscles type …
TUBB3 E410K Syndrome With Childhood-Onset Nonalcoholic Steatohepatitis.
Mori J, Umemura A, Satake W, Cha PC, Suzuki Y, Itoh K, Chiyonobu T. Mori J, et al. J Clin Endocrinol Metab. 2022 Jan 1;107(1):e38-e43. doi: 10.1210/clinem/dgab628. J Clin Endocrinol Metab. 2022. PMID: 34435630
On the other hand, in comparison with an autopsy case of NASH and a normal control, these showed coexpression of TUBB3 and TH in the liver. CONCLUSION: We report the first case of TUBB3 E410K syndrome accompanied by NASH. This case suggests that the TUBB3 mut …
On the other hand, in comparison with an autopsy case of NASH and a normal control, these showed coexpression of TUBB3 and TH in the …
TUBB3 Reverses Resistance to Docetaxel and Cabazitaxel in Prostate Cancer.
Sekino Y, Han X, Kawaguchi T, Babasaki T, Goto K, Inoue S, Hayashi T, Teishima J, Shiota M, Yasui W, Matsubara A. Sekino Y, et al. Int J Mol Sci. 2019 Aug 13;20(16):3936. doi: 10.3390/ijms20163936. Int J Mol Sci. 2019. PMID: 31412591 Free PMC article.
We analyzed the effect of TUBB3 knockdown on DTX and CBZ resistance and examined the interaction between TUBB3 and PTEN. ...Knockdown of TUBB3 enhanced PTEN expression, and PTEN knockout enhanced TUBB3 expression. ...
We analyzed the effect of TUBB3 knockdown on DTX and CBZ resistance and examined the interaction between TUBB3 and PTEN. ...Kn …
TUBB3 immunostaining improves the diagnostic accuracy of oral liquid-based cytology in squamous cell carcinoma.
Oya K, Kondo Y, Fukuda Y, Kishino M, Toyosawa S. Oya K, et al. Cytopathology. 2022 May;33(3):374-379. doi: 10.1111/cyt.13096. Epub 2022 Jan 19. Cytopathology. 2022. PMID: 34995373
Herein, we investigated the expression pattern and expression levels of TUBB3 in oral squamous cell carcinoma (SCC), and assessed whether TUBB3 immunostaining could improve the diagnostic accuracy of oral scraping liquid-based cytology (LBC). ...RESULTS: TUBB3 …
Herein, we investigated the expression pattern and expression levels of TUBB3 in oral squamous cell carcinoma (SCC), and assessed whe …
TUBB3 is associated with PTEN, neuroendocrine differentiation, and castration resistance in prostate cancer.
Sekino Y, Han X, Babasaki T, Miyamoto S, Kobatake K, Kitano H, Ikeda K, Goto K, Inoue S, Hayashi T, Teishima J, Shiota M, Takeshima Y, Yasui W, Matsubara A. Sekino Y, et al. Urol Oncol. 2021 Jun;39(6):368.e1-368.e9. doi: 10.1016/j.urolonc.2021.03.001. Epub 2021 Mar 24. Urol Oncol. 2021. PMID: 33771409
BACKGROUND: Tubulin-beta3 encoded by the Tubulin-beta3 (TUBB3) gene is a microtubule protein. Previous studies have shown that TUBB3 expression is upregulated in castration-resistant prostate cancer (CaP) and is involved in taxane resistance. ...This study aimed to …
BACKGROUND: Tubulin-beta3 encoded by the Tubulin-beta3 (TUBB3) gene is a microtubule protein. Previous studies have shown that TUB …
TUBB3 Promotes Growth and Invasion of Gallbladder Cancer Cells by Akt/mTOR Signal Pathway.
Liu Z, Li S, Dong J, Miao Y. Liu Z, et al. J Environ Pathol Toxicol Oncol. 2021;40(2):23-33. doi: 10.1615/JEnvironPatholToxicolOncol.2021036821. J Environ Pathol Toxicol Oncol. 2021. PMID: 33822514
The results revealed that TUBB3 was significantly over-expressed in gallbladder cancer samples and cell lines, and high TUBB3 level contributed to shorter overall survival in patients. The knockdown of TUBB3 with sh-TUBB3 inhibited the proliferation, m …
The results revealed that TUBB3 was significantly over-expressed in gallbladder cancer samples and cell lines, and high TUBB3 …
Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.
Radwitz J, Hausrat TJ, Heisler FF, Janiesch PC, Pechmann Y, Rübhausen M, Kneussel M. Radwitz J, et al. Cell Mol Life Sci. 2022 Oct 29;79(11):575. doi: 10.1007/s00018-022-04607-5. Cell Mol Life Sci. 2022. PMID: 36309617 Free PMC article.
Although Tubb3 mutations are associated with neuronal disease, including abnormal inhibitory transmission and seizure activity in patients, molecular consequences of altered Tubb3 levels are largely unknown. ...We found that growing microtubules and Tubb3 exp …
Although Tubb3 mutations are associated with neuronal disease, including abnormal inhibitory transmission and seizure activity in pat …
[TUBB3 role in the response of tumor cells to epothilones and taxanes].
Marczak A, Rogalska A. Marczak A, et al. Postepy Hig Med Dosw (Online). 2015 Jan 28;69:158-64. Postepy Hig Med Dosw (Online). 2015. PMID: 25661915 Free article. Review. Polish.
On the basis of the literature data it can be concluded that one reason for the ineffectiveness of taxane is the resistance growing in the case of overexpression of b-tubulin class III- (TUBB3). Epothilones, however, due to their ability to bind equally to b-tubulin class …
On the basis of the literature data it can be concluded that one reason for the ineffectiveness of taxane is the resistance growing in the c …
Class III beta-tubulin (TUBB3): more than a biomarker in solid tumors?
Mariani M, Shahabi S, Sieber S, Scambia G, Ferlini C. Mariani M, et al. Curr Mol Med. 2011 Dec;11(9):726-31. doi: 10.2174/156652411798062368. Curr Mol Med. 2011. PMID: 21999149 Review.
Class III beta-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. ...In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that inste …
Class III beta-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in …
965 results