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MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression.
Deng L, Liao L, Zhang YL, Hu SY, Yang SY, Ma XY, Huang MY, Zhang FL, Li DQ. Deng L, et al. Cancer Lett. 2023 Apr 28;560:216124. doi: 10.1016/j.canlet.2023.216124. Epub 2023 Mar 11. Cancer Lett. 2023. PMID: 36907504
Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic targets. ...Collectively, these findings reveal previously unknown functional and mechanism roles of the MYC-U2SURP-SAT1 signaling axis in TNBC progression and highlight U2S …
Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic targets. ...Collectively, these findings re …
Identification of spliceosome components pivotal to breast cancer survival.
An J, Luo Z, An W, Cao D, Ma J, Liu Z. An J, et al. RNA Biol. 2021 Jun;18(6):833-842. doi: 10.1080/15476286.2020.1822636. Epub 2020 Sep 23. RNA Biol. 2021. PMID: 32965163 Free PMC article.
Of 122 analysed spliceosome components, U2SURP, PUF60, DDX41, HNRNPAB, EIF4A3, and PPIL3 were significantly associated with breast cancer survival. ...These results were verifiable using other cohorts. The Cancer Genome Atlas data unveiled the elevated expres …
Of 122 analysed spliceosome components, U2SURP, PUF60, DDX41, HNRNPAB, EIF4A3, and PPIL3 were significantly associated with breast …
The plasma peptides of sepsis.
Thavarajah T, Dos Santos CC, Slutsky AS, Marshall JC, Bowden P, Romaschin A, Marshall JG. Thavarajah T, et al. Clin Proteomics. 2020 Jul 2;17:26. doi: 10.1186/s12014-020-09288-5. eCollection 2020. Clin Proteomics. 2020. PMID: 32636717 Free PMC article.
The endogenous tryptic peptides of ICU-Sepsis were compared to ICU Control, ovarian cancer, breast cancer, female normal, sepsis, heart attack, Alzheimer's and multiple sclerosis along with their institution-matched controls, female normals and normal samples collec …
The endogenous tryptic peptides of ICU-Sepsis were compared to ICU Control, ovarian cancer, breast cancer, female normal, seps …
LncRNA RP11-10E18.7 cooperates with lncRNA RP11-481C4.2 to affect the overall survival of breast cancer patients: a TCGA-based retrospective study.
Zhang W, Wang Y, Deng S, Zhu YC. Zhang W, et al. Transl Cancer Res. 2023 Nov 30;12(11):3156-3165. doi: 10.21037/tcr-23-1941. Epub 2023 Nov 17. Transl Cancer Res. 2023. PMID: 38130297 Free PMC article.
BACKGROUND: As either oncogenes or tumor suppressor genes, long non-coding RNAs (lncRNAs) have a major role in both tumorigenesis and progression of human cancers, including breast cancer (BC). However, the statistical correlation between the lncRNA-lncRNA interacti …
BACKGROUND: As either oncogenes or tumor suppressor genes, long non-coding RNAs (lncRNAs) have a major role in both tumorigenesis and progre …
Alternative splicing regulation of cell-cycle genes by SPF45/SR140/CHERP complex controls cell proliferation.
Martín E, Vivori C, Rogalska M, Herrero-Vicente J, Valcárcel J. Martín E, et al. RNA. 2021 Dec;27(12):1557-1576. doi: 10.1261/rna.078935.121. Epub 2021 Sep 20. RNA. 2021. PMID: 34544891 Free PMC article.
The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation, but the underlying molecular mechanisms remain poorly understood. ...
The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation, but …
U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation.
Wang Q, Wang Y, Liu Y, Zhang C, Luo Y, Guo R, Zhan Z, Wei N, Xie Z, Shen L, Wu G, Wu W, Feng Y. Wang Q, et al. Int J Cancer. 2019 Nov 15;145(10):2728-2739. doi: 10.1002/ijc.32331. Epub 2019 Apr 25. Int J Cancer. 2019. PMID: 30977118 Free article.
Dysregulation of calcium homeostasis endoplasmic reticulum protein (CHERP) has been implicated in several cancers, but it remains elusive how CHERP contributes to cancer cell proliferation and cancer development. Here, we observed that CHERP and its binding p …
Dysregulation of calcium homeostasis endoplasmic reticulum protein (CHERP) has been implicated in several cancers, but it remains elu …