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Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang G, Chiou J, Zeng C, Miller M, Matta I, Han JY, Kadakia N, Okino ML, Beebe E, Mallick M, Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. Wang G, et al. Nat Genet. 2023 Jun;55(6):984-994. doi: 10.1038/s41588-023-01397-9. Epub 2023 May 25. Nat Genet. 2023. PMID: 37231096 Free PMC article.
The Human Islet: Mini-Organ With Mega-Impact.
Walker JT, Saunders DC, Brissova M, Powers AC. Walker JT, et al. Endocr Rev. 2021 Sep 28;42(5):605-657. doi: 10.1210/endrev/bnab010. Endocr Rev. 2021. PMID: 33844836 Free PMC article. Review.
Pancreatic islet reserve in type 1 diabetes.
Flatt AJS, Greenbaum CJ, Shaw JAM, Rickels MR. Flatt AJS, et al. Ann N Y Acad Sci. 2021 Jul;1495(1):40-54. doi: 10.1111/nyas.14572. Epub 2021 Feb 6. Ann N Y Acad Sci. 2021. PMID: 33550589 Free PMC article. Review.
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Chen CW, et al. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. Nat Commun. 2022. PMID: 35941159 Free PMC article.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.
48 results