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G-quadruplex-enhanced circular single-stranded DNA (G4-CSSD) adsorption of miRNA to inhibit colon cancer progression.
Wu H, Zhong W, Zhang R, Ding Y, Qu C, Lai K, Pang Z, Yin S, Zhang G, Chen S. Wu H, et al. Cancer Med. 2023 Apr;12(8):9774-9787. doi: 10.1002/cam4.5721. Epub 2023 Feb 28. Cancer Med. 2023. PMID: 36855796 Free PMC article.
Cellular and animal experiments were performed to validate the role of G4-CSSD in cancer cell progression. RESULTS: In colon cancer, we observed the simultaneous low expressions of chloride channel accessory 1 (CLCA1), UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminy …
Cellular and animal experiments were performed to validate the role of G4-CSSD in cancer cell progression. RESULTS: In colon cance …
Colonic Mucosal Transcriptomic Changes in Patients with Long-Duration Ulcerative Colitis Revealed Colitis-Associated Cancer Pathways.
Low END, Mokhtar NM, Wong Z, Raja Ali RA. Low END, et al. J Crohns Colitis. 2019 May 27;13(6):755-763. doi: 10.1093/ecco-jcc/jjz002. J Crohns Colitis. 2019. PMID: 30954025 Free PMC article.
BACKGROUND AND AIMS: Patients with ulcerative colitis [UC] with long disease duration have a higher risk of developing colitis-associated cancer [CAC] compared with patients with short-duration UC. The aim of this study was to identify transcriptomic differences associated …
BACKGROUND AND AIMS: Patients with ulcerative colitis [UC] with long disease duration have a higher risk of developing colitis-associated …
Identification of Molecular Targets of Bile Acids Acting on Colorectal Cancer and Their Correlation with Immunity.
Yang X, Li P, Zhuang J, Wu Y, Qu Z, Wu W, Wei Q. Yang X, et al. Dig Dis Sci. 2024 Jan;69(1):123-134. doi: 10.1007/s10620-023-08032-x. Epub 2023 Nov 2. Dig Dis Sci. 2024. PMID: 37917212
RESULTS: The BA-related gene UGT2A3 is positively correlated with good prognoses in CRC. The expression level of UGT2A3 was negatively related to the BA level and positively related to the Ki67 proliferation index. ...In addition, the expression level of UGT2A3 …
RESULTS: The BA-related gene UGT2A3 is positively correlated with good prognoses in CRC. The expression level of UGT2A3 was ne …
MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.
Permuth-Wey J, Chen Z, Tsai YY, Lin HY, Chen YA, Barnholtz-Sloan J, Birrer MJ, Chanock SJ, Cramer DW, Cunningham JM, Fenstermacher D, Fridley BL, Garcia-Closas M, Gayther SA, Gentry-Maharaj A, Gonzalez-Bosquet J, Iversen E, Jim H, McLaughlin J, Menon U, Narod SA, Phelan CM, Ramus SJ, Risch H, Song H, Sutphen R, Terry KL, Tyrer J, Vierkant RA, Wentzensen N, Lancaster JM, Cheng JQ, Berchuck A, Pharoah PD, Schildkraut JM, Goode EL, Sellers TA; Ovarian Cancer Association Consortium (OCAC). Permuth-Wey J, et al. Cancer Epidemiol Biomarkers Prev. 2011 Aug;20(8):1793-7. doi: 10.1158/1055-9965.EPI-11-0397. Epub 2011 Jun 2. Cancer Epidemiol Biomarkers Prev. 2011. PMID: 21636674 Free PMC article.
BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies. ...To more adequately evaluate the relationship between gen …
BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) …
Monitoring drug metabolic pathways through extracellular vesicles in mouse plasma.
Wu X, Quan M, Hadisurya M, Hu J, Liu YK, Zhuang Y, Li L, Iliuk AB, Yang JJ, Kuang S, Tao WA. Wu X, et al. PNAS Nexus. 2024 Jan 23;3(2):pgae023. doi: 10.1093/pnasnexus/pgae023. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38312223 Free PMC article.
Out of 44 known ADME proteins in plasma EVs, previously annotated mouse cytochrome P450 3A11 (Cyp3a11), homolog to human CYP3A4, and uridine 5'-diphospho (UDP) glucuronosyltransferase 2A3 (Ugt2a3), increased upon daily rifampicin dosage. Dasatinib, a tyrosine kinase inhibi …
Out of 44 known ADME proteins in plasma EVs, previously annotated mouse cytochrome P450 3A11 (Cyp3a11), homolog to human CYP3A4, and uridine …
The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes.
Hu DG, Marri S, Mackenzie PI, Hulin JA, McKinnon RA, Meech R. Hu DG, et al. Cancers (Basel). 2021 Sep 6;13(17):4491. doi: 10.3390/cancers13174491. Cancers (Basel). 2021. PMID: 34503303 Free PMC article.
In the present study, a comprehensive analysis of the RNAseq and clinical datasets of 9514 patients from 33 different TCGA (the Genome Cancer Atlas) cancers demonstrated cancer-specific UGT expression profiles with high interindividual variability among and w …
In the present study, a comprehensive analysis of the RNAseq and clinical datasets of 9514 patients from 33 different TCGA (the Genome Ca …
Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer.
Pang B, Xu X, Lu Y, Jin H, Yang R, Jiang C, Shao D, Liu Y, Shi J. Pang B, et al. Food Funct. 2019 Sep 1;10(9):5339-5349. doi: 10.1039/c9fo01168d. Epub 2019 Aug 8. Food Funct. 2019. PMID: 31393490
Quercetin has been widely found to exhibit anticancer activity with low toxicity and prevalence in foods. Quercetin has been reported to inhibit digestive system cancers including pancreatic cancer (PAAD) and colon cancer (COAD), but rectal cancer (REA …
Quercetin has been widely found to exhibit anticancer activity with low toxicity and prevalence in foods. Quercetin has been reported to inh …
Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.
Wang S, Zhang C, Zhang Z, Qian W, Sun Y, Ji B, Zhang Y, Zhu C, Ji D, Wang Q, Sun Y. Wang S, et al. Cancer Med. 2017 Aug;6(8):1976-1987. doi: 10.1002/cam4.1147. Epub 2017 Jul 26. Cancer Med. 2017. PMID: 28745433 Free PMC article.
Colorectal cancer (CRC) is the third most common cancer worldwide and liver metastases are the leading cause of death in patients with CRC. ...The validation showed that three most significantly upregulated DEGs were HOXD10, UGT2A3, and SLC13A2, whereas the f …
Colorectal cancer (CRC) is the third most common cancer worldwide and liver metastases are the leading cause of death in patie …
Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.
Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y. Kurita A, et al. J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22. J Pharmacol Exp Ther. 2017. PMID: 28228532 Free article.
To address this issue, we characterized the substrate specificity of all isoforms of the Ugt2b subfamily expressed in the mouse liver. The cDNAs of Ugt1a1, Ugt2a3, and all the Ugt2b isoforms expressed in the liver were reverse-transcribed from the total RNA of male FVB-mou …
To address this issue, we characterized the substrate specificity of all isoforms of the Ugt2b subfamily expressed in the mouse liver. The c …