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2005 1
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27 results

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Page 1
GPC3-Unc5 receptor complex structure and role in cell migration.
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E. Akkermans O, et al. Cell. 2022 Oct 13;185(21):3931-3949.e26. doi: 10.1016/j.cell.2022.09.025. Cell. 2022. PMID: 36240740 Free PMC article.
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate. Here, we reveal crystal structures of Uncoordinated-5 receptor D (Unc5D) in com …
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer …
Down-regulation of UNC5D in bladder cancer: UNC5D as a possible mediator of cisplatin induced apoptosis in bladder cancer cells.
Zhu Y, Yu M, Chen Y, Wang Y, Wang J, Yang C, Bi J. Zhu Y, et al. J Urol. 2014 Aug;192(2):575-82. doi: 10.1016/j.juro.2014.01.108. Epub 2014 Feb 8. J Urol. 2014. PMID: 24518784
Restoration of UNC5D expression in bladder cancer cells lacking endogenous UNC5D expression suppressed cell proliferation and survival. Cisplatin treatment significantly induced UNC5D expression and DAPK dephosphorylation while UNC5D knockdown d …
Restoration of UNC5D expression in bladder cancer cells lacking endogenous UNC5D expression suppressed cell proliferati …
Tumor-suppressive function of UNC5D in papillary thyroid cancer.
Zhang MM, Sun F, Cui B, Zhang LL, Fang Y, Li Y, Zhang RJ, Ye XP, Ma YR, Han B, Song HD. Zhang MM, et al. Oncotarget. 2017 Oct 10;8(56):96126-96138. doi: 10.18632/oncotarget.21759. eCollection 2017 Nov 10. Oncotarget. 2017. PMID: 29221192 Free PMC article.
BACKGROUND: Studies have shown an association of the UNC5D gene with kidney and bladder cancer and neuroblastoma. We investigated whether UNC5D acts as a tumor suppressor in papillary thyroid carcinoma (PTC). ...PTC-derived cancer cell lines TPC-1 and …
BACKGROUND: Studies have shown an association of the UNC5D gene with kidney and bladder cancer and neuroblastoma. We investiga …
Hypermethylated promoters of genes UNC5D and KCNA1 as potential novel diagnostic biomarkers in colorectal cancer.
Uhan S, Zidar N, Tomažič A, Hauptman N. Uhan S, et al. Epigenomics. 2020 Oct;12(19):1677-1688. doi: 10.2217/epi-2020-0118. Epub 2020 Oct 20. Epigenomics. 2020. PMID: 33078631
Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes. Results: Genes KCNA1 and UNC5D displayed methylation in 95.3 and 99.7% of The Cancer Genome Atlas dataset samples and in 96 and 98% of our experimentally tested sam …
Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes. Results: Genes KCNA1 and UNC5D …
The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma.
Lu D, Dong D, Zhou Y, Lu M, Pang XW, Li Y, Tian XJ, Zhang Y, Zhang J. Lu D, et al. Clin Cancer Res. 2013 Jun 1;19(11):2883-92. doi: 10.1158/1078-0432.CCR-12-2978. Epub 2013 Apr 15. Clin Cancer Res. 2013. PMID: 23589179
Epigenetic alterations in UNC5D promoter and LOH in the UNC5D locus were also analyzed. Ectopic expression of UNC5D in renal cancer cells with silenced expression of UNC5D was used for analysis of the biologic functions of UNC5D. RESULTS: …
Epigenetic alterations in UNC5D promoter and LOH in the UNC5D locus were also analyzed. Ectopic expression of UNC5D in …
UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.
Dong D, Zhang L, Bai C, Ma N, Ji W, Jia L, Zhang A, Zhang P, Ren L, Zhou Y. Dong D, et al. Cancer Sci. 2019 Apr;110(4):1244-1255. doi: 10.1111/cas.13935. Epub 2019 Feb 20. Cancer Sci. 2019. PMID: 30632669 Free PMC article.
Prostate cancer (PCa) death primarily occurs due to metastasis of the cells, but little is known about the underlying molecular mechanisms. ...A negative correlation was observed between methylation and UNC5D mRNA expression in PCa samples. The ectopic expression of …
Prostate cancer (PCa) death primarily occurs due to metastasis of the cells, but little is known about the underlying molecular mecha …
Unc5D regulates p53-dependent apoptosis in neuroblastoma cells.
Wang H, Wu Q, Li S, Zhang B, Chi Z, Hao L. Wang H, et al. Mol Med Rep. 2014 Jun;9(6):2411-6. doi: 10.3892/mmr.2014.2100. Epub 2014 Apr 1. Mol Med Rep. 2014. PMID: 24691657
Unc5D-induced apoptosis may be largely dependent on the p53 status. ...Overexpression of p53 resulted in an increase in the expression levels of endogenous Unc5D. Additionally, two elements were identified in the sequence of Unc5D. ...
Unc5D-induced apoptosis may be largely dependent on the p53 status. ...Overexpression of p53 resulted in an increase in the expressio …
Identification of tumors with NRG1 rearrangement, including a novel putative pathogenic UNC5D-NRG1 gene fusion in prostate cancer by data-drilling a de-identified tumor database.
Ptáková N, Martínek P, Holubec L, Janovský V, Vančurová J, Grossmann P, Navarro PA, Rodriguez Moreno JF, Alaghehbandan R, Hes O, Májek O, Pešek M, Michal M, Ondič O. Ptáková N, et al. Genes Chromosomes Cancer. 2021 Jul;60(7):474-481. doi: 10.1002/gcc.22942. Epub 2021 Feb 24. Genes Chromosomes Cancer. 2021. PMID: 33583086
Identified fusion partners were of a wide range (CD74, SDC4, TNC, VAMP2, UNC5D), with CD74, SDC4 being found twice. The UNC5D is a novel fusion partner identified in prostate adenocarcinoma. ...We confirm (invasive mucinous) lung adenocarcinoma as being the most fre …
Identified fusion partners were of a wide range (CD74, SDC4, TNC, VAMP2, UNC5D), with CD74, SDC4 being found twice. The UNC5D …
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer.
Dong D, Zhang R, Shao J, Zhang A, Wang Y, Zhou Y, Li Y. Dong D, et al. Clin Epigenetics. 2021 Dec 18;13(1):225. doi: 10.1186/s13148-021-01211-5. Clin Epigenetics. 2021. PMID: 34922605 Free PMC article.
RESULTS: Methylation-mediated repression was observed in UNC5C and UNC5D, but not in UNC5A and UNC5B, which was confirmed in CRC cell lines. ...CONCLUSIONS: Hypermethylation of UNC5C and UNC5D mediates the repression and has promising diagnostic and prognostic value …
RESULTS: Methylation-mediated repression was observed in UNC5C and UNC5D, but not in UNC5A and UNC5B, which was confirmed in CRC cell …
Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.
Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A. Zhu Y, et al. J Clin Invest. 2013 Jul;123(7):2935-47. doi: 10.1172/JCI65988. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778138 Free PMC article.
NGF withdrawal strongly upregulated UNC5D, E2F1, and p53 in human primary favorable NBs. The induced UNC5D was cleaved by caspases 2/3, and the released intracellular fragment translocated into the nucleus and interacted with E2F1 to selectively transactivate the pr …
NGF withdrawal strongly upregulated UNC5D, E2F1, and p53 in human primary favorable NBs. The induced UNC5D was cleaved by casp …
27 results