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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Simoneau A, Engel JL, Bandi M, Lazarides K, Liu S, Meier SR, Choi AH, Zhang H, Shen B, Martires L, Gotur D, Pham TV, Li F, Gu L, Gong S, Zhang M, Wilker E, Pan X, Whittington DA, Throner S, Maxwell JP, Chen Y, Yu Y, Huang A, Andersen JN, Feng T. Simoneau A, et al. Mol Cancer Ther. 2023 Feb 1;22(2):215-226. doi: 10.1158/1535-7163.MCT-22-0409. Mol Cancer Ther. 2023. PMID: 36228090 Free PMC article.
Ectopic expression of WT or ubiquitin-dead K164R PCNA reverses USP1 inhibitor sensitivity. Our results show, for the first time, that USP1 dependency hinges on the aberrant processing of mono- and polyubiquitinated PCNA. ...We further show PARP and USP1 inhib …
Ectopic expression of WT or ubiquitin-dead K164R PCNA reverses USP1 inhibitor sensitivity. Our results show, for the first time, that …
USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD. Lim KS, et al. Mol Cell. 2018 Dec 20;72(6):925-941.e4. doi: 10.1016/j.molcel.2018.10.045. Mol Cell. 2018. PMID: 30576655 Free PMC article.
USP1 binds to and is stimulated by fork DNA. A truncated form of USP1, lacking its DNA-binding region, was not stimulated by DNA and failed to localize and protect replication forks. Persistence of monoubiquitinated PCNA at the replication fork was the mechanism of …
USP1 binds to and is stimulated by fork DNA. A truncated form of USP1, lacking its DNA-binding region, was not stimulated by D …
Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders.
Kitamura H. Kitamura H. Int J Mol Sci. 2023 Feb 6;24(4):3219. doi: 10.3390/ijms24043219. Int J Mol Sci. 2023. PMID: 36834633 Free PMC article. Review.
USP22 in pancreatic beta-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyper …
USP22 in pancreatic beta-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and U …
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S. Goldbraikh D, et al. EMBO Rep. 2020 Apr 3;21(4):e48791. doi: 10.15252/embr.201948791. Epub 2020 Mar 5. EMBO Rep. 2020. PMID: 32133736 Free PMC article.
DUB screening platform identified USP1 as a direct DUB for Akt, and USP1 depletion in mouse muscle increased Akt ubiquitination, PI3K-Akt-FoxO signaling, and glucose uptake during fasting. Co-immunoprecipitation and mass spectrometry identified disabled homolog-2 (D …
DUB screening platform identified USP1 as a direct DUB for Akt, and USP1 depletion in mouse muscle increased Akt ubiquitinatio …
CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.
Tyagi A, Kaushal K, Chandrasekaran AP, Sarodaya N, Das S, Park CH, Hong SH, Kim KS, Ramakrishna S. Tyagi A, et al. Theranostics. 2022 Aug 8;12(13):5949-5970. doi: 10.7150/thno.72826. eCollection 2022. Theranostics. 2022. PMID: 35966591 Free PMC article.
Furthermore, USP1-knockout A549 lung cancer cells were generated to validate the deubiquitinating activity of USP1 on MAST1 abundance. ...Loss of USP1 led to attenuation of MAST1-mediated cisplatin-resistance both in vitro and in vivo. ...
Furthermore, USP1-knockout A549 lung cancer cells were generated to validate the deubiquitinating activity of USP1 on MAST1 ab …
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis.
Liu D, Li Q, Zang Y, Li X, Li Z, Zhang P, Feng C, Yang P, Cui J, Sun Y, Wei T, Su P, Zhao X, Yang H, Ding Y. Liu D, et al. Cell Death Dis. 2023 Apr 12;14(4):264. doi: 10.1038/s41419-023-05777-1. Cell Death Dis. 2023. PMID: 37041150 Free PMC article.
RNA sequencing analysis revealed that USP1 depletion affects Hippo signaling activity in HCC cell lines. Mechanistic assays revealed that USP1 is required for Hippo/TAZ axis activity and HCC progression. ...
RNA sequencing analysis revealed that USP1 depletion affects Hippo signaling activity in HCC cell lines. Mechanistic assays revealed …
USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ.
Zhu X, Wang P, Zhan X, Zhang Y, Sheng J, He S, Chen Y, Nie D, You X, Mai H, Yu Q, Li L, Jie L, Hu S. Zhu X, et al. Cell Mol Immunol. 2023 Mar;20(3):252-263. doi: 10.1038/s41423-022-00969-9. Epub 2023 Jan 5. Cell Mol Immunol. 2023. PMID: 36600049 Free PMC article.
In this study, we identified ubiquitin-specific peptidase 1 (USP1) as a vital regulator of CD4(+) T-cell differentiation. USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation, thereby promoting the development of inflammatory diseases. .. …
In this study, we identified ubiquitin-specific peptidase 1 (USP1) as a vital regulator of CD4(+) T-cell differentiation. USP1 …
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.
Wang L, Hu T, Shen Z, Zheng Y, Geng Q, Li L, Sha B, Li M, Sun Y, Guo Y, Xue W, Xuan D, Chen P, Zhao J. Wang L, et al. Cell Death Dis. 2022 Nov 10;13(11):951. doi: 10.1038/s41419-022-05341-3. Cell Death Dis. 2022. PMID: 36357365 Free PMC article.
The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the progression of various tumors, emerging as a potential therapeutic target. This study aimed to determine the role of USP1 as a therapeutic target in hepatocellular carcinoma (HCC). …
The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the progression of various tumors, emerging as a pot …
USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation.
Zhang DY, Zhu Y, Wu Q, Ma S, Ma Y, Shen ZC, Wang Z, Sun W, Zhou YC, Wang D, Zhou S, Liu Z, Kwong LN, Lu Z. Zhang DY, et al. Cell Death Dis. 2023 Oct 11;14(10):669. doi: 10.1038/s41419-023-06172-6. Cell Death Dis. 2023. PMID: 37821462 Free PMC article.
Proteomics and ubiquitylome analysis of USP1-overexpressing CCA cells nominated PARP1 as a top USP1 substrate. ...Additionally, we identified the acetyltransferase GCN5 as acetylating USP1 at K130, enhancing the affinity between USP1 and PARP1 and furt …
Proteomics and ubiquitylome analysis of USP1-overexpressing CCA cells nominated PARP1 as a top USP1 substrate. ...Additionally …
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
Liu S, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M. Liu S, et al. Blood Adv. 2023 Jul 11;7(13):3099-3112. doi: 10.1182/bloodadvances.2022008284. Blood Adv. 2023. PMID: 36912760 Free PMC article.
USP1 depletion abolished cellular proliferation and attenuated glycolytic metabolism. ...Pharmacological inhibition of USP1 by ML323 exhibited cell cytotoxicity in human T-ALL cells. Taken together, our results demonstrated that USP1 may be a promising therap …
USP1 depletion abolished cellular proliferation and attenuated glycolytic metabolism. ...Pharmacological inhibition of USP1 by …
282 results