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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 1
2002 3
2003 3
2004 2
2005 5
2006 8
2007 9
2008 5
2009 8
2010 9
2011 21
2012 14
2013 15
2014 22
2015 21
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2022 38
2023 41
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381 results

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Page 1
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C. Hou J, et al. Nat Commun. 2021 May 20;12(1):2970. doi: 10.1038/s41467-021-23219-4. Nat Commun. 2021. PMID: 34016972 Free PMC article.
Mice with a deficiency of USP18 are more susceptible to RNA virus infection. USP18 functions as a scaffold protein to facilitate the re-localization of TRIM31 and enhances the interaction between TRIM31 and MAVS in mitochondria. Our results indicate that USP18 …
Mice with a deficiency of USP18 are more susceptible to RNA virus infection. USP18 functions as a scaffold protein to facilita …
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.
Arimoto KI, Miyauchi S, Troutman TD, Zhang Y, Liu M, Stoner SA, Davis AG, Fan JB, Huang YJ, Yan M, Glass CK, Zhang DE. Arimoto KI, et al. Nat Commun. 2023 Jan 17;14(1):251. doi: 10.1038/s41467-022-35348-5. Nat Commun. 2023. PMID: 36646704 Free PMC article.
Lower USP18 expression correlates with better survival across human selected cancer types and delays cancer progression in mouse models. ...These findings may support the use of targeting USP18 as a potential cancer immunotherapy....
Lower USP18 expression correlates with better survival across human selected cancer types and delays cancer progression in mouse mode …
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C. Lin C, et al. Cell Rep. 2023 Nov 28;42(11):113277. doi: 10.1016/j.celrep.2023.113277. Epub 2023 Oct 20. Cell Rep. 2023. PMID: 37864791 Free article.
A partial form of inherited human USP18 deficiency underlies infection and inflammation.
Martin-Fernandez M, Buta S, Le Voyer T, Li Z, Dynesen LT, Vuillier F, Franklin L, Ailal F, Muglia Amancio A, Malle L, Gruber C, Benhsaien I, Altman J, Taft J, Deswarte C, Roynard M, Nieto-Patlan A, Moriya K, Rosain J, Boddaert N, Bousfiha A, Crow YJ, Jankovic D, Sher A, Casanova JL, Pellegrini S, Bustamante J, Bogunovic D. Martin-Fernandez M, et al. J Exp Med. 2022 Apr 4;219(4):e20211273. doi: 10.1084/jem.20211273. Epub 2022 Mar 8. J Exp Med. 2022. PMID: 35258551 Free PMC article.
Human USP18 is an interferon (IFN)-stimulated gene product and a negative regulator of type I IFN (IFN-I) signaling. It also removes covalently linked ISG15 from proteins, in a process called deISGylation. In turn, ISG15 prevents USP18 from being degraded by the pro …
Human USP18 is an interferon (IFN)-stimulated gene product and a negative regulator of type I IFN (IFN-I) signaling. It also removes …
Breast Cancer [Internet].
Mayrovitz HN, editor. Mayrovitz HN, editor. Brisbane (AU): Exon Publications; 2022 Aug 6. Brisbane (AU): Exon Publications; 2022 Aug 6. PMID: 36121977 Free Books & Documents. Review.
Multiple functions of USP18.
Honke N, Shaabani N, Zhang DE, Hardt C, Lang KS. Honke N, et al. Cell Death Dis. 2016 Nov 3;7(11):e2444. doi: 10.1038/cddis.2016.326. Cell Death Dis. 2016. PMID: 27809302 Free PMC article. Review.
Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune disease …
Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions …
Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus.
Shen M, Duan C, Xie C, Wang H, Li Z, Li B, Wang T. Shen M, et al. Front Immunol. 2022 Jul 28;13:962393. doi: 10.3389/fimmu.2022.962393. eCollection 2022. Front Immunol. 2022. PMID: 35967341 Free PMC article.
The lncRNA NRIR and mRNAs (RSAD2, USP18, IFI44, and ISG15) were selected as candidate ISGs for verification. ...The Receiver Operating Characteristic (ROC) curve demonstrated that the IFI44, USP18, RSAD2, and IFN score had good diagnostic capabilities of SLE. ...
The lncRNA NRIR and mRNAs (RSAD2, USP18, IFI44, and ISG15) were selected as candidate ISGs for verification. ...The Receiver Operatin …
ISG15: It's Complicated.
Dzimianski JV, Scholte FEM, Bergeron É, Pegan SD. Dzimianski JV, et al. J Mol Biol. 2019 Oct 4;431(21):4203-4216. doi: 10.1016/j.jmb.2019.03.013. Epub 2019 Mar 16. J Mol Biol. 2019. PMID: 30890331 Free PMC article. Review.
Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.
Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, Dmitrovsky E. Mustachio LM, et al. Cancer Res. 2018 Feb 1;78(3):587-592. doi: 10.1158/0008-5472.CAN-17-1752. Epub 2018 Jan 17. Cancer Res. 2018. PMID: 29343520 Free PMC article. Review.
Prior work provides a basis for the ubiquitin-specific protease 18 (USP18) as an antineoplastic target. USP18 is the major DUB that removes IFN-stimulated gene 15 (ISG15) from conjugated proteins. ...Loss of USP18 reduced cancer cell growth by triggering apop …
Prior work provides a basis for the ubiquitin-specific protease 18 (USP18) as an antineoplastic target. USP18 is the major DUB …
381 results