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USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis.
Liu S, Wang T, Shi Y, Bai L, Wang S, Guo D, Zhang Y, Qi Y, Chen C, Zhang J, Zhang Y, Liu Q, Yang Q, Wang Y, Liu H. Liu S, et al. Cell Death Differ. 2021 Aug;28(8):2482-2498. doi: 10.1038/s41418-021-00763-6. Epub 2021 Mar 17. Cell Death Differ. 2021. PMID: 33731873 Free PMC article.
USP42 is distributed to SC35-positive nuclear speckles in a positively charged C-terminal residue- and enzymatic activity-dependent manner. ...Finally, USP42 expression is strongly correlated with that of PLRG1 in non-small-cell lung cancer samples and predicts adve …
USP42 is distributed to SC35-positive nuclear speckles in a positively charged C-terminal residue- and enzymatic activity-dependent m …
MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
Hu Z, Zhao Y, Mang Y, Zhu J, Yu L, Li L, Ran J. Hu Z, et al. Life Sci. 2023 Jul 15;325:121773. doi: 10.1016/j.lfs.2023.121773. Epub 2023 May 13. Life Sci. 2023. PMID: 37187452 Free article.
A dual-luciferase reporter assay certified that miR-21-5p targets USP42, and a co-immunoprecipitation assay validated the mutual effect between USP24 and SIRT7. RESULTS: miR-21-5p and USP42 were highly expressed in HCC tissue and cells. Inhibition of miR-21-5p or kn …
A dual-luciferase reporter assay certified that miR-21-5p targets USP42, and a co-immunoprecipitation assay validated the mutual effe …
Overexpression and Biological Function of Ubiquitin-Specific Protease 42 in Gastric Cancer.
Hou K, Zhu Z, Wang Y, Zhang C, Yu S, Zhu Q, Yan B. Hou K, et al. PLoS One. 2016 Mar 31;11(3):e0152997. doi: 10.1371/journal.pone.0152997. eCollection 2016. PLoS One. 2016. PMID: 27030989 Free PMC article. Clinical Trial.
However, there are few studies on the expression and biological function of USP42 in gastric cancer (GC). Here, the expression levels of USP42 were significantly higher in GC tissues than in non-tumorous tissues. ...Moreover, USP42 silencing in two GC cell li …
However, there are few studies on the expression and biological function of USP42 in gastric cancer (GC). Here, the expression levels …
USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.
Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. Giebel N, et al. EMBO Rep. 2021 May 5;22(5):e51415. doi: 10.15252/embr.202051415. Epub 2021 Mar 30. EMBO Rep. 2021. PMID: 33786993 Free PMC article.
USP42 binds to the Dishevelled interacting region (DIR) of ZNRF3 and stalls the R-spondin-LGR4-ZNRF3 ternary complex by deubiquitinating ZNRF3. Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling. ...
USP42 binds to the Dishevelled interacting region (DIR) of ZNRF3 and stalls the R-spondin-LGR4-ZNRF3 ternary complex by deubiquitinat …
Pediatric acute myeloid leukemia with t(7;21)(p22;q22).
Paulraj P, Diamond S, Razzaqi F, Ozeran JD, Longhurst M, Andersen EF, Toydemir RM, Hong B. Paulraj P, et al. Genes Chromosomes Cancer. 2019 Aug;58(8):551-557. doi: 10.1002/gcc.22740. Epub 2019 Feb 14. Genes Chromosomes Cancer. 2019. PMID: 30706625 Review.
The t(7;21)(p22;q22) resulting in RUNX1-USP42 fusion, is a rare but recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML) and myelodysplastic syndromes. ...
The t(7;21)(p22;q22) resulting in RUNX1-USP42 fusion, is a rare but recurrent cytogenetic abnormality associated with acute myeloid l …
Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia.
Mishra R, Kumawat KL, Basu A, Banerjea AC. Mishra R, et al. Virology. 2022 Aug;573:131-140. doi: 10.1016/j.virol.2022.06.012. Epub 2022 Jun 25. Virology. 2022. PMID: 35779335 Free article.
In this study, we show that JEV infection in human microglial cells (CHME3) reduces the cellular miR-590-3p levels. miR-590-3p could directly target the expression levels of USP42 (Ubiquitin Specific Peptidase 42) resulting in increased cellular levels of USP42 upon …
In this study, we show that JEV infection in human microglial cells (CHME3) reduces the cellular miR-590-3p levels. miR-590-3p could directl …
Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion.
Panagopoulos I, Gorunova L, Brandal P, Garnes M, Tierens A, Heim S. Panagopoulos I, et al. Oncol Rep. 2013 Oct;30(4):1549-52. doi: 10.3892/or.2013.2623. Epub 2013 Jul 18. Oncol Rep. 2013. PMID: 23877199 Free PMC article.
In the present study, we present the molecular genetic analysis and the clinical features of a t(7;21)(p22;q22)-positive AML case. PCR amplified two RUNX1-USP42 cDNA fragments but no reciprocal USP42-RUNX1 fragment indicating that the RUNX1-USP42 is the leuke …
In the present study, we present the molecular genetic analysis and the clinical features of a t(7;21)(p22;q22)-positive AML case. PCR ampli …
Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity.
Hock AK, Vigneron AM, Vousden KH. Hock AK, et al. J Biol Chem. 2014 Dec 12;289(50):34862-70. doi: 10.1074/jbc.M114.589267. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336640 Free PMC article.
We now show that USP42 can also regulate transcription independently of p53. USP42 co-localized with RNA polymerase II (RNA Pol II) in nuclear foci, bound to histone H2B, and deubiquitylated H2B. ...These results are consistent with a role for USP42 in regula …
We now show that USP42 can also regulate transcription independently of p53. USP42 co-localized with RNA polymerase II (RNA Po …
Dengue NS5 modulates expression of miR-590 to regulate ubiquitin-specific peptidase 42 in human microglia.
Mishra R, Sood V, Banerjea AC. Mishra R, et al. FASEB Bioadv. 2019 Mar 12;1(4):265-278. doi: 10.1096/fba.2018-00047. eCollection 2019 Apr. FASEB Bioadv. 2019. PMID: 32123831 Free PMC article.
DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this study to establish the interaction of miR-590 and USP42. DENV infection in human microglial cells resulted in downregulation of host …
DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this …
[Ubiquitin-specific protease 42 regulates osteogenic differentiation of human adipose-derived stem cells].
Pan Y, Gu H, Xiao H, Zhao L, Tang Y, Ge W. Pan Y, et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2024 Feb 18;56(1):9-16. doi: 10.19723/j.issn.1671-167X.2024.01.003. Beijing Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 38318890 Free PMC article. Chinese.
OBJECTIVE: To explore the effect of ubiquitin-specific protease 42 (USP42) on osteogenic differentiation of human adipose-derived stem cells (hASCs) in vivo and in vitro. ...Hematoxylin-eosin staining of subcutaneous grafts in nude mice showed that the percentage of osteoi …
OBJECTIVE: To explore the effect of ubiquitin-specific protease 42 (USP42) on osteogenic differentiation of human adipose-derived ste …
35 results