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2009 2
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USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.
Ren Y, Feng M, Hao X, Liu X, Li J, Li P, Gao J, Qi Q, Du L, Wang C, Wang Q, Wang Y. Ren Y, et al. Cancer Res. 2023 Apr 4;83(7):1074-1093. doi: 10.1158/0008-5472.CAN-22-1812. Cancer Res. 2023. PMID: 36607699
USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME). USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189. ...SIGNIFICANCE: USP48 promotes pyroptosis by deubiquitinating GSDME and enhances antitumor immunity, indicating …
USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME). USP48 bound GSDME and removed K48-linked ubiquitination at posit …
Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders.
Kitamura H. Kitamura H. Int J Mol Sci. 2023 Feb 6;24(4):3219. doi: 10.3390/ijms24043219. Int J Mol Sci. 2023. PMID: 36834633 Free PMC article. Review.
USP9X, 14, 17, and 20 in vascular cells are postulated to be determinants of atherosclerosis. Moreover, mutations in the Usp8 and Usp48 loci in pituitary tumors cause Cushing syndrome. This review summarizes the current knowledge about the modulatory roles of USPs in energ …
USP9X, 14, 17, and 20 in vascular cells are postulated to be determinants of atherosclerosis. Moreover, mutations in the Usp8 and Usp48 …
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Du L, Li Y, Kang M, Feng M, Ren Y, Dai H, Wang Y, Wang Y, Tang B. Du L, et al. Cancer Res. 2021 Jul 15;81(14):3822-3834. doi: 10.1158/0008-5472.CAN-20-4163. Epub 2021 Apr 26. Cancer Res. 2021. PMID: 33903120
However, the role of USP48 in HCC tumorigenesis remains unknown. In this study, we report that expression of USP48 is downregulated in diethylnitrosamine-induced liver tumorigenesis in mice as well as in human HCC. ...Moreover, methyltransferase-like 14 (Mettl14)-in …
However, the role of USP48 in HCC tumorigenesis remains unknown. In this study, we report that expression of USP48 is downregu …
Genetics of Cushing's disease.
Simon J, Theodoropoulou M. Simon J, et al. J Neuroendocrinol. 2022 Aug;34(8):e13148. doi: 10.1111/jne.13148. Epub 2022 May 21. J Neuroendocrinol. 2022. PMID: 35596671 Review.
Recurrent mutations in the ubiquitin specific protease 8 (USP8) gene are found in around half of cases. Mutations in other genes such as USP48 and NR3C1 are less frequent, found in less than ~20% of cases. ...
Recurrent mutations in the ubiquitin specific protease 8 (USP8) gene are found in around half of cases. Mutations in other genes such as …
Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1.
Zhou A, Lin K, Zhang S, Ma L, Xue J, Morris SA, Aldape KD, Huang S. Zhou A, et al. EMBO Rep. 2017 Aug;18(8):1318-1330. doi: 10.15252/embr.201643124. Epub 2017 Jun 16. EMBO Rep. 2017. PMID: 28623188 Free PMC article.
Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly. ...In human glioblastoma specimens, the expression levels of USP48 and Gli1 proteins are clinically relevant, and high expression of USP48 correlates with glioma malignancy. .. …
Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly. ...In human glioblastoma specimens, the expression …
The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions.
Li S, Wang D, Zhao J, Weathington NM, Shang D, Zhao Y. Li S, et al. FASEB J. 2018 Jan;32(1):230-242. doi: 10.1096/fj.201700415RR. Epub 2017 Sep 5. FASEB J. 2018. PMID: 28874458 Free PMC article.
Down-regulation of USP48 increases K48-linked polyubiquitination of TRAF2 and reduces TRAF2 protein levels. ...USP48 is serine phosphorylated in response to TNF-alpha. The phosphorylation is catalyzed by glycogen synthase kinase 3beta (GSK3beta), ultimately resultin …
Down-regulation of USP48 increases K48-linked polyubiquitination of TRAF2 and reduces TRAF2 protein levels. ...USP48 is serine …
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Sánchez-Bellver L, Férriz-Gordillo A, Carrillo-Pz M, Rabanal L, Garcia-Gonzalo FR, Marfany G. Sánchez-Bellver L, et al. Int J Mol Sci. 2022 Oct 19;23(20):12527. doi: 10.3390/ijms232012527. Int J Mol Sci. 2022. PMID: 36293380 Free PMC article.
In this work, we describe that a pool of endogenous USP48 localises to the basal body in retinal cells and provide data that supports the function of USP48 in the photoreceptor cilium. We also demonstrate that USP48 interacts with the IRD-associated proteins …
In this work, we describe that a pool of endogenous USP48 localises to the basal body in retinal cells and provide data that supports …
USP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer.
Lei X, Li X, Chen H, Liu Z. Lei X, et al. Curr Cancer Drug Targets. 2020;20(9):689-699. doi: 10.2174/1568009620666200503045400. Curr Cancer Drug Targets. 2020. PMID: 32359336
BACKGROUND: Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. ...CONCLUSION: In summary, USP48 may be a potential therapeutic target for ovarian cancer patients....
BACKGROUND: Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. ...CONCLUSION: In summa …
Deubiquitinase USP48 promotes ATRA-induced granulocytic differentiation of acute promyelocytic leukemia cells.
Li L, Wang Y, Zhang X, Song G, Guo Q, Zhang Z, Diao Y, Yin H, Liu H, Jiang G. Li L, et al. Int J Oncol. 2018 Aug;53(2):895-903. doi: 10.3892/ijo.2018.4440. Epub 2018 Jun 13. Int J Oncol. 2018. PMID: 29901102
In the present study, the role of USP48 in ATRA-induced differentiation of APL cells was studied. The expression of USP48 decreased following ATRA treatment. ...The inverse observations were made upon siRNA-mediated knockdown of USP48. Furthermore, the expres …
In the present study, the role of USP48 in ATRA-induced differentiation of APL cells was studied. The expression of USP48 decr …
Hotspots of Somatic Genetic Variation in Pituitary Neuroendocrine Tumors.
Torres-Morán M, Franco-Álvarez AL, Rebollar-Vega RG, Hernández-Ramírez LC. Torres-Morán M, et al. Cancers (Basel). 2023 Dec 1;15(23):5685. doi: 10.3390/cancers15235685. Cancers (Basel). 2023. PMID: 38067388 Free PMC article. Review.
A small number of non-USP8-driven corticotropinomas are due to somatic hotspot variants in USP48 or BRAF; the latter is a well-known mutational hotspot in cancer. Finally, somatic variants affecting a hotspot in SF3B1 have been associated with multiple cancers and, more re …
A small number of non-USP8-driven corticotropinomas are due to somatic hotspot variants in USP48 or BRAF; the latter is a well-known …
73 results