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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2007 1
2010 4
2011 2
2012 3
2013 3
2014 3
2015 14
2016 10
2017 13
2018 19
2019 22
2020 25
2021 22
2022 34
2023 22
2024 11

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183 results

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Page 1
USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-beta receptor TbetaRII.
Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P, Zhou F, Zhang L. Xie F, et al. EMBO J. 2022 Aug 16;41(16):e108791. doi: 10.15252/embj.2021108791. Epub 2022 Jul 11. EMBO J. 2022. PMID: 35811497 Free PMC article.
USP8 acts both as a cancer stemness-promoting factor and an activator of the TGF-beta/SMAD signaling pathway. ...Our findings not only reveal a novel mechanism whereby USP8 regulates the cancer microenvironment but also demonstrate the therapeutic adva …
USP8 acts both as a cancer stemness-promoting factor and an activator of the TGF-beta/SMAD signaling pathway. ...Our findings …
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy.
Li H, Sun Y, Yao Y, Ke S, Zhang N, Xiong W, Shi J, He C, Xiao X, Yu H, Dai P, Xiang B, Xing X, Xu G, Song W, Song J, Zhang J. Li H, et al. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2315541121. doi: 10.1073/pnas.2315541121. Epub 2024 Apr 10. Proc Natl Acad Sci U S A. 2024. PMID: 38598341
Thus, USP8 inhibition destabilizes GPX4 and sensitizes cancer cells to ferroptosis in vitro. ...These findings uncover that USP8 counteracts ferroptosis by stabilizing GPX4 and highlight targeting USP8 as a potential therapeutic strategy to boost ferro …
Thus, USP8 inhibition destabilizes GPX4 and sensitizes cancer cells to ferroptosis in vitro. ...These findings uncover that …
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
Xiong W, Gao X, Zhang T, Jiang B, Hu MM, Bu X, Gao Y, Zhang LZ, Xiao BL, He C, Sun Y, Li H, Shi J, Xiao X, Xiang B, Xie C, Chen G, Zhang H, Wei W, Freeman GJ, Shu HB, Wang H, Zhang J. Xiong W, et al. Nat Commun. 2022 Mar 31;13(1):1700. doi: 10.1038/s41467-022-29401-6. Nat Commun. 2022. PMID: 35361799 Free PMC article.
In addition, USP8 inhibition also triggers innate immune response and MHC-I expression largely through activating the NF-kappaB signaling. ...Thus, our study reveals a potential combined therapeutic strategy to utilize a USP8 inhibitor and PD-1/PD-L1 blockade for en …
In addition, USP8 inhibition also triggers innate immune response and MHC-I expression largely through activating the NF-kappaB signa …
USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2.
Cui J, Guo Y, Yin T, Gou S, Xiong J, Liang X, Lu C, Peng T. Cui J, et al. Biomed Pharmacother. 2023 Oct;166:115359. doi: 10.1016/j.biopha.2023.115359. Epub 2023 Aug 28. Biomed Pharmacother. 2023. PMID: 37639742 Free article.
As a deubiquitinating enzyme, ubiquitin-specific protease 8 (USP8) was shown to play vital roles in the tumorigenesis processes of several cancers; however, the effect of USP8 on Gem resistance of pancreatic cancer still remains largely unknown. ...In …
As a deubiquitinating enzyme, ubiquitin-specific protease 8 (USP8) was shown to play vital roles in the tumorigenesis processes of se …
Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT.
Tang J, Long G, Hu K, Xiao D, Liu S, Xiao L, Zhou L, Tao Y. Tang J, et al. Adv Sci (Weinh). 2023 Nov;10(33):e2302953. doi: 10.1002/advs.202302953. Epub 2023 Oct 22. Adv Sci (Weinh). 2023. PMID: 37867237 Free PMC article.
It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB-IN-3 shows the most effective anti-cancer responses. Targeting USP8 inhibits the proliferation of HCC and induces cell ferroptosis. ...
It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB-IN-3 shows the most effective anti-cancer resp …
USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-kappaB activation and autophagy induction by TLR4.
Kim MJ, Choi B, Kim JY, Min Y, Kwon DH, Son J, Lee JS, Lee JS, Chun E, Lee KY. Kim MJ, et al. Transl Oncol. 2022 Jan;15(1):101250. doi: 10.1016/j.tranon.2021.101250. Epub 2021 Oct 20. Transl Oncol. 2022. PMID: 34688043 Free PMC article.
Herein, we aimed to elucidate the molecular and cellular mechanism in which ubiquitin-specific protease 8 (USP8) is implicated in liver cancer progression via TRAF6-mediated signal. ...Notably, the LIHC patient with low USP8 mRNA expression showed markedly sh …
Herein, we aimed to elucidate the molecular and cellular mechanism in which ubiquitin-specific protease 8 (USP8) is implicated in liv …
The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics.
Islam MT, Chen F, Chen H. Islam MT, et al. Arch Biochem Biophys. 2021 Apr 15;701:108811. doi: 10.1016/j.abb.2021.108811. Epub 2021 Feb 16. Arch Biochem Biophys. 2021. PMID: 33600786 Review.
The upregulated or mutated USP8 becomes hyperactivated and stabilizes numerous oncogenes or proto-oncogenes leading to cancer progression and survival by activating multiple signaling pathways. Moreover, USP8 inhibition is also important to overcome anticance …
The upregulated or mutated USP8 becomes hyperactivated and stabilizes numerous oncogenes or proto-oncogenes leading to cancer …
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.
Yang H, Zhang X, Lao M, Sun K, He L, Xu J, Duan Y, Chen Y, Ying H, Li M, Guo C, Lu Q, Wang S, Su W, Liang T, Bai X. Yang H, et al. Cell Death Differ. 2023 Feb;30(2):560-575. doi: 10.1038/s41418-022-01102-z. Epub 2022 Dec 20. Cell Death Differ. 2023. PMID: 36539510 Free PMC article.
Clinically, the expression of USP8 showed a significant association with the tumor-node-metastasis stage in multiple patient-derived cohorts of pancreatic cancer. ...Moreover, USP8 interacted positively with PD-L1 and upregulated its expression by inhibiting …
Clinically, the expression of USP8 showed a significant association with the tumor-node-metastasis stage in multiple patient-derived …
Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation.
Sun J, Shen D, Gao Y, Zheng Y, Zhao L, Maa M, Liu H, Chen X. Sun J, et al. Onco Targets Ther. 2020 Aug 11;13:7973-7984. doi: 10.2147/OTT.S264108. eCollection 2020. Onco Targets Ther. 2020. PMID: 32848421 Free PMC article.
However, the role and functional mechanisms of USP8 and HER-3 in gastric cancer (GC) remain unknown. OBJECTIVE: To explore the function and mechanism of USP8 and HER-3 in the progression of GC. ...USP8i and si-RNA were then used to down-regulate USP8 i …
However, the role and functional mechanisms of USP8 and HER-3 in gastric cancer (GC) remain unknown. OBJECTIVE: To explore the …
Knockdown of USP8 Inhibits the Growth of Lung Cancer Cells.
Rong Z, Zhu Z, Cai S, Zhang B. Rong Z, et al. Cancer Manag Res. 2020 Dec 2;12:12415-12422. doi: 10.2147/IJN.S259191. eCollection 2020. Cancer Manag Res. 2020. PMID: 33293867 Free PMC article.
PURPOSE: Lung cancer is the deadliest tumor in the world. This study aimed to investigate the effection of USP8 on the proliferation and growth of NSCLC cells. ...USP8 may be a therapeutic target for lung cancer....
PURPOSE: Lung cancer is the deadliest tumor in the world. This study aimed to investigate the effection of USP8 on the prolife …
183 results