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The nuclear receptor Rev-erbα participates in circadian regulation of Ugt2b enzymes in mice.
Zhang T, Guo L, Yu F, Chen M, Wu B. Zhang T, et al. Biochem Pharmacol. 2019 Mar;161:89-97. doi: 10.1016/j.bcp.2019.01.010. Epub 2019 Jan 11. Biochem Pharmacol. 2019. PMID: 30639455
Circadian variations in hepatic mRNA expression were observed for six Ugt2b genes (Ugt2b1, Ugt2b5, Ugt2b35, Ugt2b36, Ugt2b37, and Ugt2b38) in mice. Likewise, the total Ugt2b protein showed a circadian fluctuation. ...
Circadian variations in hepatic mRNA expression were observed for six Ugt2b genes (Ugt2b1, Ugt2b5, Ugt2b35, Ugt2b36, Ugt2b37, and Ugt2b38
Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses.
Connerney J, Lau-Corona D, Rampersaud A, Waxman DJ. Connerney J, et al. Endocrinology. 2017 May 1;158(5):1386-1405. doi: 10.1210/en.2017-00060. Endocrinology. 2017. PMID: 28323953 Free PMC article.
Rapid increases in liver chromatin accessibility and transcriptional activity were also induced in hypophysectomized male mice for some (Ces2b, Ugt2b38) but not for other liver STAT5-dependent male-biased genes (Cyp7b1). Moreover, in pituitary-intact male mice, Igf1, Cish, …
Rapid increases in liver chromatin accessibility and transcriptional activity were also induced in hypophysectomized male mice for some (Ces …
Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney.
Buckley DB, Klaassen CD. Buckley DB, et al. Drug Metab Dispos. 2009 Apr;37(4):834-40. doi: 10.1124/dmd.108.024224. Epub 2009 Jan 8. Drug Metab Dispos. 2009. PMID: 19131521 Free PMC article.
Messenger RNA expression of mouse Ugt isozymes was determined by the branched DNA assay. In C57BL/6 mice, male-predominant expression of Ugt2b1 and Ugt2b38 was observed in liver and kidney, respectively. Female-predominant expression was observed for Ugt1a1 and Ugt1a5 in l …
Messenger RNA expression of mouse Ugt isozymes was determined by the branched DNA assay. In C57BL/6 mice, male-predominant expression of Ugt …
Lotus seed resistant starch ameliorates high-fat diet induced hyperlipidemia by fatty acid degradation and glycerolipid metabolism pathways in mouse liver.
He S, Xiong Z, Li L, Wang Y, Wang C, Zheng B, Zeng H, Zhang Y. He S, et al. Int J Biol Macromol. 2022 Aug 31;215:79-91. doi: 10.1016/j.ijbiomac.2022.06.077. Epub 2022 Jun 16. Int J Biol Macromol. 2022. PMID: 35718147
LLRS supplementation significantly regulated genes associated with glycerolipid metabolism and steroid hormone biosynthesis (Lpin1 and Ugt2b38), MLRS significantly regulated genes related to fatty acid degradation, fatty acid elongation, and glycerolipid metabolism (Lpin1, …
LLRS supplementation significantly regulated genes associated with glycerolipid metabolism and steroid hormone biosynthesis (Lpin1 and Ug
Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone.
Dkhil MA, Al-Quraishy S, Abdel-Baki AA, Ghanjati F, Arauzo-Bravo MJ, Delic D, Wunderlich F. Dkhil MA, et al. J Steroid Biochem Mol Biol. 2015 Jan;145:121-30. doi: 10.1016/j.jsbmb.2014.11.006. Epub 2014 Nov 6. J Steroid Biochem Mol Biol. 2015. PMID: 25448745
Surprisingly, the promoters are largely unmethylated in those genes whose expression has been previously found to be permanently deregulated by T in the liver, as e.g. the T-upregulated male-predominant genes Cyp7b1, Cyp2d9, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, Slco1a1 as wel …
Surprisingly, the promoters are largely unmethylated in those genes whose expression has been previously found to be permanently deregulated …
Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection.
Delić D, Gailus N, Vohr HW, Dkhil M, Al-Quraishy S, Wunderlich F. Delić D, et al. J Mol Endocrinol. 2010 Dec;45(6):379-90. doi: 10.1677/JME-10-0026. Epub 2010 Sep 15. J Mol Endocrinol. 2010. PMID: 20844152
Most genes were involved in liver metabolism: the female-prevalent genes Cyp2b9, Cyp2b13, Cyp3a41, Cyp3a44, Fmo3, Sult2a2, Sult3a1, and BC014805 were repressed, while the male-prevalent genes Cyp2d9, Cyp7b1, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, and Slco1a1 were upregulated. G …
Most genes were involved in liver metabolism: the female-prevalent genes Cyp2b9, Cyp2b13, Cyp3a41, Cyp3a44, Fmo3, Sult2a2, Sult3a1, and BC01 …