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1998 2
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2008 7
2009 13
2010 14
2011 43
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2,467 results

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Kim J, Kundu M, Viollet B, Guan KL. Kim J, et al. Nat Cell Biol. 2011 Feb;13(2):132-41. doi: 10.1038/ncb2152. Epub 2011 Jan 23. Nat Cell Biol. 2011. PMID: 21258367 Free PMC article.
Under nutrient sufficiency, high mTOR activity prevents Ulk1 activation by phosphorylating Ulk1 Ser 757 and disrupting the interaction between Ulk1 and AMPK. This coordinated phosphorylation is important for Ulk1 in autophagy induction. Our study has r …
Under nutrient sufficiency, high mTOR activity prevents Ulk1 activation by phosphorylating Ulk1 Ser 757 and disrupting the int …
Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKalpha1/ULK1/FUNDC1/mitophagy pathway.
Cai C, Guo Z, Chang X, Li Z, Wu F, He J, Cao T, Wang K, Shi N, Zhou H, Toan S, Muid D, Tan Y. Cai C, et al. Redox Biol. 2022 Jun;52:102288. doi: 10.1016/j.redox.2022.102288. Epub 2022 Mar 18. Redox Biol. 2022. PMID: 35325804 Free PMC article.
Empagliflozin exerted these protective effects by activating FUNDC1-dependent mitophagy through the AMPKalpha1/ULK1 pathway. Both in vitro and in vivo, genetic ablation of AMPKalpha1 or FUNDC1 abolished the beneficial effects of empagliflozin on the myocardial microvascula …
Empagliflozin exerted these protective effects by activating FUNDC1-dependent mitophagy through the AMPKalpha1/ULK1 pathway. Both in …
The mammalian ULK1 complex and autophagy initiation.
Zachari M, Ganley IG. Zachari M, et al. Essays Biochem. 2017 Dec 12;61(6):585-596. doi: 10.1042/EBC20170021. Print 2017 Dec 12. Essays Biochem. 2017. PMID: 29233870 Free PMC article. Review.
In this artcile, we focus on the regulation of the ULK1 complex during autophagy initiation. The complex pattern of upstream pathways that converge on ULK1 suggests that this complex acts as a node, converting multiple signals into autophagosome formation. Here, we …
In this artcile, we focus on the regulation of the ULK1 complex during autophagy initiation. The complex pattern of upstream pathways …
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis.
Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, Huang Y, Li X, Peng XD, Feng GK, Li JD, Tang J, Zhu XF. Deng R, et al. Autophagy. 2021 Oct;17(10):3011-3029. doi: 10.1080/15548627.2020.1850609. Epub 2020 Dec 7. Autophagy. 2021. PMID: 33213267 Free PMC article.
Here, we show that ULK1 deficiency induces an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis. ...Also, a clearly negative correlation between the expression levels of ULK1 and p-MAPK1/3 was observed in human breast c …
Here, we show that ULK1 deficiency induces an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone m …
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan JL, Liu L, Wu M, Chen S. Yang Y, et al. EMBO J. 2022 Jul 18;41(14):e109777. doi: 10.15252/embj.2021109777. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670107 Free PMC article.
Here, we reveal that the E3 ubiquitin ligase TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex. TRIM27 directly polyubiquitinates ULK1 at K568 and K571 sites with K48-linked ubiquitin chains, with proteasomal turnover maintaining c …
Here, we reveal that the E3 ubiquitin ligase TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex. TR …
Physiological functions of ULK1/2.
Pareek G, Kundu M. Pareek G, et al. J Mol Biol. 2024 Feb 2:168472. doi: 10.1016/j.jmb.2024.168472. Online ahead of print. J Mol Biol. 2024. PMID: 38311233 Free article. Review.
UNC-51-like kinases 1 and 2 (ULK1/2) are serine/threonine kinases that are best known for their evolutionarily conserved role in the autophagy pathway. ...Growing evidence suggests that ULK1/2 function as biological rheostats, tuning cellular functions to intra and …
UNC-51-like kinases 1 and 2 (ULK1/2) are serine/threonine kinases that are best known for their evolutionarily conserved role in the …
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ. Vargas JNS, et al. Mol Cell. 2019 Apr 18;74(2):347-362.e6. doi: 10.1016/j.molcel.2019.02.010. Epub 2019 Mar 7. Mol Cell. 2019. PMID: 30853401 Free PMC article.
Ectopically tethering ULK1 to cargo bypasses the requirement for autophagy receptors and TBK1. Focal activation of ULK1 occurs independently of AMPK and mTOR. Our findings provide a parsimonious model of selective autophagy, which highlights the coordination of U …
Ectopically tethering ULK1 to cargo bypasses the requirement for autophagy receptors and TBK1. Focal activation of ULK1 occurs …
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease.
Ma Z, Li L, Livingston MJ, Zhang D, Mi Q, Zhang M, Ding HF, Huo Y, Mei C, Dong Z. Ma Z, et al. J Clin Invest. 2020 Sep 1;130(9):5011-5026. doi: 10.1172/JCI135536. J Clin Invest. 2020. PMID: 32804155 Free PMC article.
Furthermore, blockade of p53 attenuated miR-214 induction in DKD, leading to higher levels of ULK1 and autophagy, accompanied by an amelioration of DKD. Compared with nondiabetic samples, renal biopsies from patients with diabetes showed induction of p53 and miR-214, assoc …
Furthermore, blockade of p53 attenuated miR-214 induction in DKD, leading to higher levels of ULK1 and autophagy, accompanied by an a …
Function and regulation of ULK1: From physiology to pathology.
Rong Z, Zheng K, Chen J, Jin X. Rong Z, et al. Gene. 2022 Oct 5;840:146772. doi: 10.1016/j.gene.2022.146772. Epub 2022 Jul 26. Gene. 2022. PMID: 35905845 Review.
The expression of ULK1, a core protein of autophagy, is closely related to autophagic activity. ...In addition, new advances in the regulation of ULK1 have been identified. Furthermore, targeting ULK1 as a therapeutic strategy for diseases is gaining attentio …
The expression of ULK1, a core protein of autophagy, is closely related to autophagic activity. ...In addition, new advances in the r …
Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy.
Yang YY, Gao ZX, Mao ZH, Liu DW, Liu ZS, Wu P. Yang YY, et al. Front Endocrinol (Lausanne). 2023 Jan 18;13:1079465. doi: 10.3389/fendo.2022.1079465. eCollection 2022. Front Endocrinol (Lausanne). 2023. PMID: 36743936 Free PMC article.
In the training set, the AUROC of MFN1, ULK1 and PARK2 were 0.839, 0.906 and 0.842. However, the results of the validation set demonstrated that MFN1 and PARK2 had no significant difference in distinguishing DN samples from healthy controls, while the AUROC of ULK1 …
In the training set, the AUROC of MFN1, ULK1 and PARK2 were 0.839, 0.906 and 0.842. However, the results of the validation set demons …
2,467 results