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Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types.
Li Y, Sundquist K, Zhang N, Wang X, Sundquist J, Memon AA. Li Y, et al. EBioMedicine. 2023 Feb;88:104432. doi: 10.1016/j.ebiom.2022.104432. Epub 2023 Jan 10. EBioMedicine. 2023. PMID: 36634566 Free PMC article.
A Bayesian test for colocalization between mitochondrial molecular QTLs and cancer risk loci was performed to provide insights into the potential regulatory mechanisms of risk variants on cancers. ...We found strong evidence of positive association of FDPS expressio …
A Bayesian test for colocalization between mitochondrial molecular QTLs and cancer risk loci was performed to provide insights into t …
VARS2 V552V variant as prognostic marker in patients with early breast cancer.
Chae YS, Lee SJ, Moon JH, Kang BW, Kim JG, Sohn SK, Jung JH, Park HY, Park JY, Kim HJ, Lee SW. Chae YS, et al. Med Oncol. 2011 Dec;28(4):1273-80. doi: 10.1007/s12032-010-9574-4. Epub 2010 May 26. Med Oncol. 2011. PMID: 20503108
In particular, the VARS2 rs2074511 polymorphism was only associated with survival in patients with triple negative (TN)-type breast cancer (P=0.018 for DFS and 0.042 for DDFS, respectively). In conclusion, VARS2 V552V may be considered as a prognostic factor …
In particular, the VARS2 rs2074511 polymorphism was only associated with survival in patients with triple negative (TN)-type breast …
A novel mitochondria-related gene signature for controlling colon cancer cell mitochondrial respiration and proliferation.
Zhu Z, Hou Q, Wang B, Li C, Liu L, Gong W, Chai J, Guo H. Zhu Z, et al. Hum Cell. 2022 Jul;35(4):1126-1139. doi: 10.1007/s13577-022-00702-8. Epub 2022 Apr 16. Hum Cell. 2022. PMID: 35429326
Eventually, five hub genes were identified, namely, POLG, FASTK, MRPS5, AARS2, and VARS2. Functional analyses showed that all these five hub genes are essential for maintaining mitochondrial respiration and proliferation of colon cancer cells. ...In summary, our stu …
Eventually, five hub genes were identified, namely, POLG, FASTK, MRPS5, AARS2, and VARS2. Functional analyses showed that all these f …
Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction.
Baris A, Fraile-Bethencourt E, Eubanks J, Khou S, Anand S. Baris A, et al. Cell Death Dis. 2023 Apr 26;14(4):294. doi: 10.1038/s41419-023-05821-0. Cell Death Dis. 2023. PMID: 37100811 Free PMC article.
Our RIG-I induced gene signature was also conserved in the context of human diseases - in lung cancer vasculature and herpesvirus infection of lung endothelial cells. ...Functional RNAi screen of our TYMP dependent EC genes, we found that a group of 5 genes - Flot1, Ccl5, …
Our RIG-I induced gene signature was also conserved in the context of human diseases - in lung cancer vasculature and herpesvirus inf …
Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region.
van Kooij M, de Groot K, van Vugt H, Aten J, Snoek M. van Kooij M, et al. Immunogenetics. 2001 Oct;53(8):656-61. doi: 10.1007/s00251-001-0381-0. Epub 2001 Nov 6. Immunogenetics. 2001. PMID: 11797099
Three genes are located within this interval, G7e (encoding a viral envelope protein), G7a/ Vars2 (encoding valyl-tRNA synthetase), and G7c (a gene with unknown function). ...In conclusion, the previously observed phenotype could not be associated with or assigned to any o …
Three genes are located within this interval, G7e (encoding a viral envelope protein), G7a/ Vars2 (encoding valyl-tRNA synthetase), a …
A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes.
Lv L, Huang Y, Li Q, Wu Y, Zheng L. Lv L, et al. Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241258570. doi: 10.1177/15330338241258570. Technol Cancer Res Treat. 2024. PMID: 38832431 Free PMC article.
The nuclear mitochondrial-related genes (NMRGs)-related risk prognostic model and prognostic nomogram were constructed, and NMRGs-related gene mutation and the immune environment were analyzed using bioinformatics methods. Then, a liver metastasis model of colorectal cancer …
The nuclear mitochondrial-related genes (NMRGs)-related risk prognostic model and prognostic nomogram were constructed, and NMRGs-related ge …