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Accelerating inhibitor discovery for deubiquitinating enzymes.
Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, Varca AC, Hu B, Bratt AS, DaSilva E, Schauer NJ, Jaen Maisonet I, Dolen EK, Ayala AX, Marto JA, Buhrlage SJ. Chan WC, et al. Nat Commun. 2023 Feb 8;14(1):686. doi: 10.1038/s41467-023-36246-0. Nat Commun. 2023. PMID: 36754960 Free PMC article.
Optimization of an azetidine hit yields a probe for the understudied DUB VCPIP1 with nanomolar potency and in-family selectivity. Our success in identifying good chemical starting points as well as structure-activity relationships across the gene family from a modest but p …
Optimization of an azetidine hit yields a probe for the understudied DUB VCPIP1 with nanomolar potency and in-family selectivity. Our …
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY. Bai Y, et al. Autophagy. 2023 May;19(5):1562-1581. doi: 10.1080/15548627.2022.2140558. Epub 2022 Nov 7. Autophagy. 2023. PMID: 36300783 Free PMC article.
Overexpression of PTP4A phosphatases are associated with advanced cancers, but their biological functions are far from fully understood due to limited knowledge about their physiological substrates. ...Our study suggests that PTP4A2 targeting could be a potential therapeut …
Overexpression of PTP4A phosphatases are associated with advanced cancers, but their biological functions are far from fully understo …
Hepatitis B Virus X Protein Is Stabilized by the Deubiquitinating Enzyme VCPIP1 in a Ubiquitin-Independent Manner by Recruiting the 26S Proteasome Subunit PSMC3.
Wu Q, Zhang L, Xu X, Zhang Y, Shi J, Lin X, Chen W. Wu Q, et al. J Virol. 2022 Jul 13;96(13):e0061122. doi: 10.1128/jvi.00611-22. Epub 2022 Jun 13. J Virol. 2022. PMID: 35695579 Free PMC article.
We used a 74-DUB library-based yeast two-hybrid assay and determined that a novel DUB, valosin-containing protein-interacting protein 1 (VCPIP1), interacted with HBx. VCPIP1 and its C-terminal amino acids 863 to 1221 upregulated the HBx protein expression, with or w …
We used a 74-DUB library-based yeast two-hybrid assay and determined that a novel DUB, valosin-containing protein-interacting protein 1 ( …
USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.
Perry M, Biegert M, Kollala SS, Mallard H, Su G, Kodavati M, Kreiling N, Holbrook A, Ghosal G. Perry M, et al. J Biol Chem. 2021 Jan-Jun;296:100396. doi: 10.1016/j.jbc.2021.100396. Epub 2021 Feb 7. J Biol Chem. 2021. PMID: 33567341 Free PMC article.
SPRTN function is tightly regulated by a monoubiquitin switch that controls SPRTN auto-proteolysis and chromatin accessibility during DPC repair. Previously, VCPIP1 and USP7 deubiquitinases have been shown to regulate SPRTN. ...
SPRTN function is tightly regulated by a monoubiquitin switch that controls SPRTN auto-proteolysis and chromatin accessibility during DPC re …
Characterization of MYBL1 Gene in Triple-Negative Breast Cancers and the Genes' Relationship to Alterations Identified at the Chromosome 8q Loci.
Player A, Cunningham S, Philio D, Roy R, Haynes C, Dixon C, Thirston L, Ibikunle F, Boswell TA, Alnakhalah A, Contreras J, Bell M, McGuffery T, Bryant S, Nganya C, Kanu S. Player A, et al. Int J Mol Sci. 2024 Feb 22;25(5):2539. doi: 10.3390/ijms25052539. Int J Mol Sci. 2024. PMID: 38473786 Free PMC article.
The MYBL1 gene is a strong transcriptional activator involved in events associated with cancer progression. Previous data show MYBL1 overexpressed in triple-negative breast cancer (TNBC). ...The four genes are located at chromosomal regions 8q13.1 to 8q.24.3 loci, r …
The MYBL1 gene is a strong transcriptional activator involved in events associated with cancer progression. Previous data show MYBL1 …
Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication.
Tsai YC, Kotiya A, Kiris E, Yang M, Bavari S, Tessarollo L, Oyler GA, Weissman AM. Tsai YC, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5158-E5166. doi: 10.1073/pnas.1621076114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584101 Free PMC article.
However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deubiquitinating enzyme binds BoNT/A light chain directly, with the two associating in cells through the C-terminal 77 amino acids of the light …
However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deu …
[Novel methylation and expression markers associated with breast cancer].
Kuznetsova EB, Kekeeva TV, Larin SS, Zemliakova VV, Babenko OV, Nemtsova MV, Zaletaev DV, Strel'nikov VV. Kuznetsova EB, et al. Mol Biol (Mosk). 2007 Jul-Aug;41(4):624-33. Mol Biol (Mosk). 2007. PMID: 17936981 Russian.
We have developed a modification of methylation sensitive arbitrarily primed PCR, one of the methods of differentially methylated CpG islands in cancer cells genomes screening. Seven genes undergoing abnormal epigenetic regulation in breast cancer, SEMA6B, BIN1, …
We have developed a modification of methylation sensitive arbitrarily primed PCR, one of the methods of differentially methylated CpG island …
Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors.
Bubola J, MacMillan CM, Demicco EG, Chami RA, Chung CT, Leong I, Marrano P, Onkal Z, Swanson D, Veremis BM, Weinreb I, Zhang L, Antonescu CR, Dickson BC. Bubola J, et al. Genes Chromosomes Cancer. 2021 Oct;60(10):695-708. doi: 10.1002/gcc.22979. Epub 2021 Jul 8. Genes Chromosomes Cancer. 2021. PMID: 34176176 Free PMC article.
Salivary gland tumors represent a diverse group of neoplasms that occasionally pose a diagnostic challenge for pathologists, particularly with limited sampling. ...In summary, targeted RNA sequencing represents a diagnostically useful ancillary technique for identifying a …
Salivary gland tumors represent a diverse group of neoplasms that occasionally pose a diagnostic challenge for pathologists, particul …
Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.
Lawson AP, Bak DW, Shannon DA, Long MJC, Vijaykumar T, Yu R, Oualid FE, Weerapana E, Hedstrom L. Lawson AP, et al. Oncotarget. 2017 Apr 20;8(31):51296-51316. doi: 10.18632/oncotarget.17261. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881649 Free PMC article.
DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurodegeneration, and inflammation. Using SILAC assisted quantitative mass spectrometry, here we identify 9 new PEITC-DUB targets: USP1, USP3, USP …
DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurode …