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1983 1
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1994 25
1995 46
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1997 57
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2001 109
2002 121
2003 118
2004 128
2005 140
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2008 171
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4,688 results

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Page 1
PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis.
Badoiu SC, Greabu M, Miricescu D, Stanescu-Spinu II, Ilinca R, Balan DG, Balcangiu-Stroescu AE, Mihai DA, Vacaroiu IA, Stefani C, Jinga V. Badoiu SC, et al. Int J Mol Sci. 2023 May 7;24(9):8391. doi: 10.3390/ijms24098391. Int J Mol Sci. 2023. PMID: 37176098 Free PMC article. Review.
Renal cell carcinoma (RCC) represents 85-95% of kidney cancers and is the most frequent type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th place among the most frequent histological types of cancer. ...
Renal cell carcinoma (RCC) represents 85-95% of kidney cancers and is the most frequent type of renal cancer in adult patients …
TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss.
Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q. Hu L, et al. Cancer Discov. 2020 Mar;10(3):460-475. doi: 10.1158/2159-8290.CD-19-0837. Epub 2019 Dec 6. Cancer Discov. 2020. PMID: 31810986 Free PMC article.
Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss display elevated TBK1 phosphorylation. Loss of TBK1 via genetic ablation, pharmacologic inhib …
Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients …
A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRbeta Signaling Drives Clear Cell Renal Cell Carcinoma Progression.
Yang J, Luo L, Zhao C, Li X, Wang Z, Zeng Z, Yang X, Zheng X, Jie H, Kang L, Li S, Liu S, Zhou C, Liu H. Yang J, et al. Int J Biol Sci. 2022 May 13;18(8):3470-3483. doi: 10.7150/ijbs.73398. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637958 Free PMC article.
Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal cell carcinoma (ccRCC). Here, we identify a previously unknown oncogenic role for inactive VHL in actively triggering histone lactyl …
Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal …
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin WG Jr. Kaelin WG Jr. Trans Am Clin Climatol Assoc. 2017;128:298-307. Trans Am Clin Climatol Assoc. 2017. PMID: 28790514 Free PMC article. Review.
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL …
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defec …
Telomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer.
Li SC, Jia ZK, Yang JJ, Ning XH. Li SC, et al. Front Immunol. 2022 Sep 16;13:975057. doi: 10.3389/fimmu.2022.975057. eCollection 2022. Front Immunol. 2022. PMID: 36189312 Free PMC article.
Kidney cancer is one of the most common urological cancers worldwide, and kidney renal clear cell cancer (KIRC) is the major histologic subtype. Our previous study found that von-Hippel Lindau (VHL) gene mutation, the dominant reason for sporadic KIRC …
Kidney cancer is one of the most common urological cancers worldwide, and kidney renal clear cell cancer (KIRC) is the …
Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics.
Chan DA, Giaccia AJ. Chan DA, et al. Cell Cycle. 2008 Oct;7(19):2987-90. doi: 10.4161/cc.7.19.6776. Epub 2008 Oct 12. Cell Cycle. 2008. PMID: 18818511 Review.
Standard cytotoxic agents for treating cancer were developed based on their effectiveness to kill rapidly dividing cells, not on their ability to selectively kill cancer cells and spare normal tissue. Much of contemporary cancer research is aimed at identifyi …
Standard cytotoxic agents for treating cancer were developed based on their effectiveness to kill rapidly dividing cells, not on thei …
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.
Hu J, Tan P, Ishihara M, Bayley NA, Schokrpur S, Reynoso JG, Zhang Y, Lim RJ, Dumitras C, Yang L, Dubinett SM, Jat PS, Van Snick J, Huang J, Chin AI, Prins RM, Graeber TG, Xu H, Wu L. Hu J, et al. Signal Transduct Target Ther. 2023 Apr 17;8(1):155. doi: 10.1038/s41392-023-01362-2. Signal Transduct Target Ther. 2023. PMID: 37069149 Free PMC article.
The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but diminished proliferation and tumorigenicity compared to the parental VHL-expressing (VHL(+)) cells. Renal tumors with either …
The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but …
Hereditary Renal Cancer Syndromes.
Yanus GA, Kuligina ES, Imyanitov EN. Yanus GA, et al. Med Sci (Basel). 2024 Feb 18;12(1):12. doi: 10.3390/medsci12010012. Med Sci (Basel). 2024. PMID: 38390862 Free PMC article. Review.
Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). ...The HIF2aplha inhibitor belzut …
Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed …
Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells.
Li C, Hu S, Yue Y. Li C, et al. Ultrasound Med Biol. 2021 Mar;47(3):723-732. doi: 10.1016/j.ultrasmedbio.2020.11.001. Epub 2020 Nov 28. Ultrasound Med Biol. 2021. PMID: 33261909
According to the literature, the von Hippel-Lindau (VHL) gene has a certain correlation with ovarian cancer. In this study, we investigated the effect and mechanism of ultrasound microbubble-mediated VHL on the biological function of ovarian cancer cel …
According to the literature, the von Hippel-Lindau (VHL) gene has a certain correlation with ovarian cancer. In this study, we …
Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein.
Kaelin WG Jr. Kaelin WG Jr. Cancer. 2009 May 15;115(10 Suppl):2262-72. doi: 10.1002/cncr.24232. Cancer. 2009. PMID: 19402056 Free article. Review.
Germline inactivation of the VHL tumor suppressor gene is associated with an increased risk of clear cell carcinoma of the kidney in the context of von Hippel-Lindau (VHL) disease. Somatic VHL mutations are also common in nonhereditary (sporadic) clear cell c …
Germline inactivation of the VHL tumor suppressor gene is associated with an increased risk of clear cell carcinoma of the kidney in …
4,688 results