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SPI1-induced upregulation of lncRNA SNHG6 promotes non-small cell lung cancer via miR-485-3p/VPS45 axis.
Gao N, Ye B. Gao N, et al. Biomed Pharmacother. 2020 Sep;129:110239. doi: 10.1016/j.biopha.2020.110239. Epub 2020 Jun 23. Biomed Pharmacother. 2020. PMID: 32590190 Free article.
More and more researches have proved that long noncoding RNAs (lncRNAs) are vital regulators and biological participants in human cancers [1-5]. SnoRNA host gene 6 (SNHG6) was found to have an effect on the early stage and tumorigenesis in many cancers [6-10]. ...In …
More and more researches have proved that long noncoding RNAs (lncRNAs) are vital regulators and biological participants in human cancers …
How we approach: Severe congenital neutropenia and myelofibrosis due to mutations in VPS45.
Shadur B, Asherie N, Newburger PE, Stepensky P. Shadur B, et al. Pediatr Blood Cancer. 2019 Jan;66(1):e27473. doi: 10.1002/pbc.27473. Epub 2018 Oct 7. Pediatr Blood Cancer. 2019. PMID: 30294941 Free PMC article. Review.
Mutations in the VPS45 gene lead to a severe primary immune deficiency characterized by severe congenital neutropenia and primary myelofibrosis, leading to overwhelming infection and early death. ...
Mutations in the VPS45 gene lead to a severe primary immune deficiency characterized by severe congenital neutropenia and primary mye …
Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.
Yamanoi K, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Murakami R, Taki M, Hosoe Y, Murphy SK, Konishi I, Mandai M, Matsumura N. Yamanoi K, et al. Sci Rep. 2019 Oct 2;9(1):14215. doi: 10.1038/s41598-019-50794-w. Sci Rep. 2019. PMID: 31578411 Free PMC article.
Side population (SP) cells harbor malignant phenotypes in cancer. The aim of this study was to identify genes that modulate the proportion of ovarian cancer SP cells. ...In ovarian cancer cases, low expression of MSL3, ZNF691 and VPS45 was related to p …
Side population (SP) cells harbor malignant phenotypes in cancer. The aim of this study was to identify genes that modulate the propo …
A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis.
Shah RK, Munson M, Wierenga KJ, Pokala HR, Newburger PE, Crawford D. Shah RK, et al. Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26571. Epub 2017 Apr 28. Pediatr Blood Cancer. 2017. PMID: 28453180
VPS45-associated severe congenital neutropenia (SCN) is a rare disorder characterized by life-threating infections, neutropenia, neutrophil and platelet dysfunction, poor response to filgrastim, and myelofibrosis with extramedullary hematopoiesis. We present a patient with …
VPS45-associated severe congenital neutropenia (SCN) is a rare disorder characterized by life-threating infections, neutropenia, neut …
Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells.
Rahajeng J, Caplan S, Naslavsky N. Rahajeng J, et al. Exp Cell Res. 2010 Mar 10;316(5):859-74. doi: 10.1016/j.yexcr.2009.11.007. Epub 2009 Nov 17. Exp Cell Res. 2010. PMID: 19931244 Free PMC article.
In several invertebrate organisms, the Sec1p/Munc18-like protein Vps45 interacts with the divalent Rab4/Rab5 effector, Rabenosyn-5 and carries out multiple functions in the endocytic/secretory pathways. In mammalian cells, Vps45 and Rabenosyn-5 also interact, but th …
In several invertebrate organisms, the Sec1p/Munc18-like protein Vps45 interacts with the divalent Rab4/Rab5 effector, Rabenosyn-5 an …
Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses.
Parisi X, Bledsoe JR. Parisi X, et al. J Clin Pathol. 2024 Apr 8:jcp-2022-208686. doi: 10.1136/jcp-2022-208686. Online ahead of print. J Clin Pathol. 2024. PMID: 38589208 Review.
The clinical and pathological overlap between reactive conditions, primary and congenital neutropenias, bone marrow failure, and myelodysplastic syndromes further clouds diagnostic clarity.We review the diagnostically useful clinicopathological and morphological features of react …
The clinical and pathological overlap between reactive conditions, primary and congenital neutropenias, bone marrow failure, and myelodyspla …
Successful treatment with daratumumab for post-HSCT refractory hemolytic anemia.
Even-Or E, Naser Eddin A, Shadur B, Dinur Schejter Y, Najajreh M, Zelig O, Zaidman I, Stepensky P. Even-Or E, et al. Pediatr Blood Cancer. 2020 Jan;67(1):e28010. doi: 10.1002/pbc.28010. Epub 2019 Sep 22. Pediatr Blood Cancer. 2020. PMID: 31544339
We present a case of a pediatric patient with primary myelofibrosis of infancy caused by VPS45 protein deficiency, who developed severe refractory hemolytic anemia and immune-mediated thrombocytopenia 3.5 months following HSCT. ...
We present a case of a pediatric patient with primary myelofibrosis of infancy caused by VPS45 protein deficiency, who developed seve …
A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer.
Ortega Duran M, Shaheed SU, Sutton CW, Shnyder SD. Ortega Duran M, et al. Cells. 2024 Feb 14;13(4):342. doi: 10.3390/cells13040342. Cells. 2024. PMID: 38391955 Free PMC article.
One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU). ...Among 3003 commonly quantified proteins, six (CD44, APP, NAGLU, CORO7, AGR2, PLSCR1) were found u …
One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment wi …
15 results