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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 1
2003 1
2006 1
2007 1
2008 4
2011 1
2017 1
2018 1
2019 2
2020 3
2021 1
2022 2
2023 1
2024 0

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20 results

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Page 1
VPS53 Suppresses Malignant Properties in Colorectal Cancer by Inducing the Autophagy Signaling Pathway.
Peng H, Zheng J, Su Q, Feng X, Peng M, Gong L, Wu H, Pan X. Peng H, et al. Onco Targets Ther. 2020 Oct 21;13:10667-10675. doi: 10.2147/OTT.S254823. eCollection 2020. Onco Targets Ther. 2020. PMID: 33116643 Free PMC article.
AIM: This study investigated the functions and molecular mechanisms of VPS53 in colorectal cancer (CRC). METHODS: Expression and correlation of Beclin 1 and VPS53 were analyzed by RT-qPCR and Pearson's correlation in CRC tissues, and VPS53 expression w …
AIM: This study investigated the functions and molecular mechanisms of VPS53 in colorectal cancer (CRC). METHODS: Expression a …
Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG.
Giannareas N, Zhang Q, Yang X, Na R, Tian Y, Yang Y, Ruan X, Huang D, Yang X, Wang C, Zhang P, Manninen A, Wang L, Wei GH. Giannareas N, et al. Nat Commun. 2022 Nov 28;13(1):7320. doi: 10.1038/s41467-022-34994-z. Nat Commun. 2022. PMID: 36443337 Free PMC article.
Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. ...We finally show that HNF1B co-opts ERG fusion to mediate mechanistic and biological effects of t …
Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and cl …
SHU00238 Promotes Colorectal Cancer Cell Apoptosis Through miR-4701-3p and miR-4793-3p.
Wang H, Ma Y, Lin Y, Chen R, Xu B, Deng J. Wang H, et al. Front Genet. 2020 Jan 10;10:1320. doi: 10.3389/fgene.2019.01320. eCollection 2019. Front Genet. 2020. PMID: 31998373 Free PMC article.
Colorectal cancer is one of the most leading causes of death. Searching for new therapeutic targets for colorectal cancer is urgently needed. ...Finally, we found that SMARCA5, MBD3, VPS53, EHD4 are estimated to mediate the regulation of miR-4701-3p and miR-4 …
Colorectal cancer is one of the most leading causes of death. Searching for new therapeutic targets for colorectal cancer is u …
GZFLW Induces Apoptosis of Ectopic Endometrial Stromal Cells via Promoting VPS53 Protein Stability.
Zhang Z, Liu F, Xu Y, Huang H, Zou Y, Yang B, Luo Y, Zhang Q, Xiong A, Wang L, Huang O. Zhang Z, et al. Evid Based Complement Alternat Med. 2018 Dec 13;2018:1293630. doi: 10.1155/2018/1293630. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30643524 Free PMC article.
Our results demonstrated that GZFLW decreased Y14 cells proliferation while increased cells apoptosis. The differential expression protein VPS53 (Vacuolar protein sorting 53 homolog) was predicted by iTRAQ coupled LC-MS/MS and further identified by western blot. Besides, G …
Our results demonstrated that GZFLW decreased Y14 cells proliferation while increased cells apoptosis. The differential expression protein …
Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition.
Ren N, Liu Q, Yan L, Huang Q. Ren N, et al. Int J Mol Sci. 2021 Aug 16;22(16):8792. doi: 10.3390/ijms22168792. Int J Mol Sci. 2021. PMID: 34445492 Free PMC article.
For one of the regulatory SNPs, rs684232, we found that the variation altered chromatin binding of transcription factor FOXA1 on the DNA region and led to aberrant gene expression of VPS53, FAM57A, and GEMIN4, which play vital roles in prostate cancer malignancy. Ou …
For one of the regulatory SNPs, rs684232, we found that the variation altered chromatin binding of transcription factor FOXA1 on the DNA reg …
The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer.
Ramanand SG, Chen Y, Yuan J, Daescu K, Lambros MB, Houlahan KE, Carreira S, Yuan W, Baek G, Sharp A, Paschalis A, Kanchwala M, Gao Y, Aslam A, Safdar N, Zhan X, Raj GV, Xing C, Boutros PC, de Bono J, Zhang MQ, Mani RS. Ramanand SG, et al. J Clin Invest. 2020 Aug 3;130(8):3987-4005. doi: 10.1172/JCI134260. J Clin Invest. 2020. PMID: 32343676 Free PMC article.
Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions in normal prostate cells and PCa cells. ...By integrating clinical PCa data, we defined a germline-somatic interp …
Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associat …
HCCS1 inhibits the stemness of human pancreatic cancer stem-like cells.
Xie XH, Chen YR, Jin S, Ma YS, Tian XD, Yang YM. Xie XH, et al. Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2125-2131. doi: 10.26355/eurrev_201903_17256. Eur Rev Med Pharmacol Sci. 2019. PMID: 30915757 Free article.
In vivo experiments showed that HCCS1 knockdown greatly enhanced the tumorigenicity of SW1990-SE cells in nude mice. CONCLUSIONS: This study first obtains the human pancreatic cancer stem-like cells SW1990-SE through consecutive spheroid enrichment. ...
In vivo experiments showed that HCCS1 knockdown greatly enhanced the tumorigenicity of SW1990-SE cells in nude mice. CONCLUSIONS: This study …
HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy.
Xu HN, Huang WD, Cai Y, Ding M, Gu JF, Wei N, Sun LY, Cao X, Li HG, Zhang KJ, Liu XR, Liu XY. Xu HN, et al. Mol Cancer. 2011 Nov 1;10:133. doi: 10.1186/1476-4598-10-133. Mol Cancer. 2011. PMID: 22040050 Free PMC article.
BACKGROUND: In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. ...RESULTS: Ad.SPD …
BACKGROUND: In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer …
Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer.
Kim TE, Kim YW, Hwang SY, Shin SM, Shin JW, Lee YH, Shin SY, Han KT, Lee JM, Namkoong SE, Kim JW. Kim TE, et al. Int J Cancer. 2002 Feb 20;97(6):780-6. doi: 10.1002/ijc.10124. Int J Cancer. 2002. PMID: 11857354 Free article.
To identify the genes involved in cervical carcinogenesis, we applied the mRNA differential display method and identified a candidate tumor suppressor gene, HCCS-1, which was present in normal cervical tissue but absent in cervical cancer, metastatic lymph node and CUMC-6 …
To identify the genes involved in cervical carcinogenesis, we applied the mRNA differential display method and identified a candidate tumor …
mRNA Capture Sequencing and RT-qPCR for the Detection of Pathognomonic, Novel, and Secondary Fusion Transcripts in FFPE Tissue: A Sarcoma Showcase.
Decock A, Creytens D, Lefever S, Van der Meulen J, Anckaert J, De Ganck A, Deleu J, De Wilde B, Fierro C, Kuersten S, Luypaert M, Rottiers I, Schroth GP, Steyaert S, Vanderheyden K, Vanden Eynde E, Verniers K, Verreth J, Van Dorpe J, Vandesompele J. Decock A, et al. Int J Mol Sci. 2022 Sep 20;23(19):11007. doi: 10.3390/ijms231911007. Int J Mol Sci. 2022. PMID: 36232302 Free PMC article.
To validate our workflow, six positive control tumors with a specific chromosomal rearrangement were analyzed using the TruSight RNA Pan-Cancer Panel. Fusion transcript calling by FusionCatcher confirmed these aberrations and enabled the identification of both fusion gene …
To validate our workflow, six positive control tumors with a specific chromosomal rearrangement were analyzed using the TruSight RNA Pan- …
20 results