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Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. Electronic address: recoverytrial@ndph.ox.ac.uk; RECOVERY Collaborative Group. RECOVERY Collaborative Group. Electronic address: recoverytrial@ndph.ox.ac.uk, et al. Lancet. 2023 May 6;401(10387):1499-1507. doi: 10.1016/S0140-6736(23)00510-X. Epub 2023 Apr 13. Lancet. 2023. PMID: 37060915 Free PMC article. Clinical Trial.
The primary outcome was 28-day mortality among all randomised participants. On May 11, 2022, the independent data monitoring committee recommended stopping recruitment of patients receiving no oxygen or simple oxygen only due to safety concerns. ...The RECOVERY trial is re …
The primary outcome was 28-day mortality among all randomised participants. On May 11, 2022, the independent data monitoring committe …
Arc controls alcohol cue relapse by a central amygdala mechanism.
Pagano R, Salamian A, Zielinski J, Beroun A, Nalberczak-Skóra M, Skonieczna E, Cały A, Tay N, Banaschewski T, Desrivières S, Grigis A, Garavan H, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R; IMAGEN consortium; Kalita K, Bito H, Müller CP, Schumann G, Okuno H, Radwanska K. Pagano R, et al. Mol Psychiatry. 2023 Feb;28(2):733-745. doi: 10.1038/s41380-022-01849-4. Epub 2022 Nov 10. Mol Psychiatry. 2023. PMID: 36357670
Clinical Effectiveness of Muscarinic Receptor-Targeted Interventions in Neuropsychiatric Disorders: A Systematic Review.
Vaidya S, Guerin AA, Walker LC, Lawrence AJ. Vaidya S, et al. CNS Drugs. 2022 Nov;36(11):1171-1206. doi: 10.1007/s40263-022-00964-8. Epub 2022 Oct 21. CNS Drugs. 2022. PMID: 36269510 Free PMC article.
METHODS: PubMed, EMBASE, PsycINFO, EBSCO and Web of Science were searched using relevant keywords from database inception to 7 August 2022. Randomised, double-blind, placebo-controlled studies were included if they investigated the effect of muscarinic receptor-targeted in …
METHODS: PubMed, EMBASE, PsycINFO, EBSCO and Web of Science were searched using relevant keywords from database inception to 7 August 202 …
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. RECOVERY Collaborative Group. Lancet Child Adolesc Health. 2024 Mar;8(3):190-200. doi: 10.1016/S2352-4642(23)00316-4. Epub 2024 Jan 22. Lancet Child Adolesc Health. 2024. PMID: 38272046 Free article. Clinical Trial.
The trial was registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). FINDINGS: Between May 18, 2020, and Jan 20, 2022, 237 children with PIMS-TS were enrolled and included in the intention-to-treat analysis. ...
The trial was registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). FINDINGS: Between May 18, 2020, and Jan 20, 2022 …
Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior.
Tiwari P, Kapri D, Pradhan A, Balakrishnan A, Chaudhari PR, Vaidya VA. Tiwari P, et al. eNeuro. 2022 Feb 15;9(1):ENEURO.0381-21.2021. doi: 10.1523/ENEURO.0381-21.2021. Print 2022 Jan-Feb. eNeuro. 2022. PMID: 35115382 Free PMC article.
To address the role of G(i) signaling in these developmental windows, we used a CaMKIIalpha-tTA::TRE hM4Di bigenic mouse line to express the hM4Di-DREADD (designer receptor exclusively activated by designer drugs) in forebrain excitatory neurons and enhanced G(i) signaling …
To address the role of G(i) signaling in these developmental windows, we used a CaMKIIalpha-tTA::TRE hM4Di bigenic mouse line to express the …
Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains.
Gazula H, Rootes-Murdy K, Holla B, Basodi S, Zhang Z, Verner E, Kelly R, Murthy P, Chakrabarti A, Basu D, Bhagyalakshmi Nanjayya S, Lenin Singh R, Lourembam Singh R, Kalyanram K, Kartik K, Kalyanaraman K, Ghattu K, Kuriyan R, Kurpad SS, Barker GJ, Bharath RD, Desrivieres S, Purushottam M, Orfanos DP, Sharma E, Hickman M, Toledano M, Vaidya N, Banaschewski T, Bokde ALW, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Paillére Martinot ML, Artiges E, Nees F, Paus T, Poustka L, Fröhner JH, Robinson L, Smolka MN, Walter H, Winterer J, Whelan R; IMAGEN Consortium; Turner JA, Sarwate AD, Plis SM, Benegal V, Schumann G, Calhoun VD. Gazula H, et al. Neuroinformatics. 2023 Apr;21(2):287-301. doi: 10.1007/s12021-022-09604-4. Epub 2022 Nov 25. Neuroinformatics. 2023. PMID: 36434478