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Iodination of salicylic acid improves its binding to transthyretin.
Gales L, Almeida MR, Arsequell G, Valencia G, Saraiva MJ, Damas AM. Gales L, et al. Among authors: valencia g. Biochim Biophys Acta. 2008 Mar;1784(3):512-7. doi: 10.1016/j.bbapap.2007.11.014. Epub 2007 Dec 3. Biochim Biophys Acta. 2008. PMID: 18155178
Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.
Gimeno A, Santos LM, Alemi M, Rivas J, Blasi D, Cotrina EY, Llop J, Valencia G, Cardoso I, Quintana J, Arsequell G, Jiménez-Barbero J. Gimeno A, et al. Among authors: valencia g. J Med Chem. 2017 Jul 13;60(13):5749-5758. doi: 10.1021/acs.jmedchem.7b00428. Epub 2017 Jun 16. J Med Chem. 2017. PMID: 28587455
Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Rios X, Gómez-Vallejo V, Martín A, Cossío U, Morcillo MÁ, Alemi M, Cardoso I, Quintana J, Jiménez-Barbero J, Cotrina EY, Valencia G, Arsequell G, Llop J. Rios X, et al. Among authors: valencia g. Sci Rep. 2019 Sep 20;9(1):13672. doi: 10.1038/s41598-019-50071-w. Sci Rep. 2019. PMID: 31541162 Free PMC article.
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
González A, Quirante J, Nieto J, Almeida MR, Saraiva MJ, Planas A, Arsequell G, Valencia G. González A, et al. Among authors: valencia g. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5270-3. doi: 10.1016/j.bmcl.2009.03.004. Epub 2009 Mar 6. Bioorg Med Chem Lett. 2009. PMID: 19651509
203 results