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Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action.
Bradley ME, Dombrecht B, Manini J, Willis J, Vlerick D, De Taeye S, Van den Heede K, Roobrouck A, Grot E, Kent TC, Laeremans T, Steffensen S, Van Heeke G, Brown Z, Charlton SJ, Cromie KD. Bradley ME, et al. Among authors: van heeke g. Mol Pharmacol. 2015 Feb;87(2):251-62. doi: 10.1124/mol.114.094821. Epub 2014 Dec 2. Mol Pharmacol. 2015. PMID: 25468882
Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys.
Dudal S, Subramanian K, Flandre T, Law WS, Lowe PJ, Skerjanec A, Genin JC, Duval M, Piequet A, Cordier A, Jarai G, Van Heeke G, Taplin S, Krantz C, Jones S, Warren AP, Brennan FR, Sims J, Lloyd P. Dudal S, et al. Among authors: van heeke g. MAbs. 2015;7(5):829-37. doi: 10.1080/19420862.2015.1060384. MAbs. 2015. PMID: 26230385 Free PMC article.
Nanobodies and their Use in GPCR Drug Discovery.
Cromie KD, Van Heeke G, Boutton C. Cromie KD, et al. Among authors: van heeke g. Curr Top Med Chem. 2015;15(24):2543-57. doi: 10.2174/1568026615666150701113549. Curr Top Med Chem. 2015. PMID: 26126902 Review.
Nanobodies® as inhaled biotherapeutics for lung diseases.
Van Heeke G, Allosery K, De Brabandere V, De Smedt T, Detalle L, de Fougerolles A. Van Heeke G, et al. Pharmacol Ther. 2017 Jan;169:47-56. doi: 10.1016/j.pharmthera.2016.06.012. Epub 2016 Jun 29. Pharmacol Ther. 2017. PMID: 27373507 Review.
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD. Lynch MJ, et al. Among authors: van heeke g. J Biol Chem. 2005 Sep 30;280(39):33178-89. doi: 10.1074/jbc.M414316200. Epub 2005 Jul 19. J Biol Chem. 2005. PMID: 16030021 Free article.
34 results