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Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.
Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19.
Toxicol Lett. 2015.
PMID: 25704631
Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity.
Van den Hof WF, Van Summeren A, Lommen A, Coonen ML, Brauers K, van Herwijnen M, Wodzig WK, Kleinjans JC.
Van den Hof WF, et al. Among authors: van summeren a.
Toxicology. 2014 Oct 3;324:18-26. doi: 10.1016/j.tox.2014.06.003. Epub 2014 Jul 15.
Toxicology. 2014.
PMID: 25047351
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Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC.
Van Summeren A, et al.
Toxicol Sci. 2011 Mar;120(1):109-22. doi: 10.1093/toxsci/kfq380. Epub 2010 Dec 16.
Toxicol Sci. 2011.
PMID: 21163907
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Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.
Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC.
Van Summeren A, et al.
Toxicol In Vitro. 2012 Apr;26(3):373-85. doi: 10.1016/j.tiv.2012.01.012. Epub 2012 Jan 17.
Toxicol In Vitro. 2012.
PMID: 22274661
Review.
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Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach.
Van Summeren A, Renes J, Lizarraga D, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC.
Van Summeren A, et al.
OMICS. 2013 Feb;17(2):71-83. doi: 10.1089/omi.2012.0079. Epub 2013 Jan 11.
OMICS. 2013.
PMID: 23308384
Free PMC article.
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Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.
Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC.
Van den Hof WF, et al. Among authors: van summeren a.
Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3.
Toxicol In Vitro. 2015.
PMID: 25562108
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