Lipid mixing between lipoplexes and plasma lipoproteins is a major barrier for intravenous transfection mediated by cationic lipids.
Tandia BM, Lonez C, Vandenbranden M, Ruysschaert JM, Elouahabi A.
Tandia BM, et al. Among authors: vandenbranden m.
J Biol Chem. 2005 Apr 1;280(13):12255-61. doi: 10.1074/jbc.M414517200. Epub 2005 Jan 20.
J Biol Chem. 2005.
PMID: 15661732
Free article.
It has been previously shown that transfection activity of cationic liposome/DNA lipoplexes delivered systemically is drastically inhibited by lipoproteins (Tandia, B. M., Vandenbranden, M., Wattiez, R., Lakhdar, Z., Ruysschaert, J. M., and Elouahabi, …
It has been previously shown that transfection activity of cationic liposome/DNA lipoplexes delivered systemically is drastically inhibited …