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Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.
Novakova Z, Wozniak K, Jancarik A, Rais R, Wu Y, Pavlicek J, Ferraris D, Havlinova B, Ptacek J, Vavra J, Hin N, Rojas C, Majer P, Slusher BS, Tsukamoto T, Barinka C. Novakova Z, et al. Among authors: vavra j. J Med Chem. 2016 May 26;59(10):4539-50. doi: 10.1021/acs.jmedchem.5b01806. Epub 2016 Apr 25. J Med Chem. 2016. PMID: 27074627
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.
Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincová L, Bařinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, Slusher BS. Rais R, et al. Among authors: vavra j. J Med Chem. 2017 Sep 28;60(18):7799-7809. doi: 10.1021/acs.jmedchem.7b00825. Epub 2017 Sep 18. J Med Chem. 2017. PMID: 28759215 Free PMC article.
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R. Zimmermann SC, et al. Among authors: vavra j. J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29648826
Tunable Chiral Second-Order Nonlinear Optical Chromophores Based on Helquat Dications.
Buckley LER, Coe BJ, Rusanova D, Joshi VD, Sánchez S, Jirásek M, Vávra J, Khobragade D, Severa L, Císařová I, Šaman D, Pohl R, Clays K, Depotter G, Brunschwig BS, Teplý F. Buckley LER, et al. Among authors: vavra j. J Phys Chem A. 2017 Aug 10;121(31):5842-5855. doi: 10.1021/acs.jpca.7b06057. Epub 2017 Jul 31. J Phys Chem A. 2017. PMID: 28703585
Metastable Brominated Nanodiamond Surface Enables Room Temperature and Catalysis-Free Amine Chemistry.
Melendrez C, Lopez-Rosas JA, Stokes CX, Cheung TC, Lee SJ, Titus CJ, Valenzuela J, Jeanpierre G, Muhammad H, Tran P, Sandoval PJ, Supreme T, Altoe V, Vavra J, Raabova H, Vanek V, Sainio S, Doriese WB, O'Neil GC, Swetz DS, Ullom JN, Irwin K, Nordlund D, Cigler P, Wolcott A. Melendrez C, et al. Among authors: vavra j. J Phys Chem Lett. 2022 Feb 3;13(4):1147-1158. doi: 10.1021/acs.jpclett.1c04090. Epub 2022 Jan 27. J Phys Chem Lett. 2022. PMID: 35084184 Free PMC article.
Functional helquats: helical cationic dyes with marked, switchable chiroptical properties in the visible region.
Reyes-Gutiérrez PE, Jirásek M, Severa L, Novotná P, Koval D, Sázelová P, Vávra J, Meyer A, Císařová I, Šaman D, Pohl R, Štěpánek P, Slavíček P, Coe BJ, Hájek M, Kašička V, Urbanová M, Teplý F. Reyes-Gutiérrez PE, et al. Among authors: vavra j. Chem Commun (Camb). 2015 Jan 31;51(9):1583-6. doi: 10.1039/c4cc08967g. Chem Commun (Camb). 2015. PMID: 25555172
415 results