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Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW. Jensen DD, et al. Among authors: veldhuis na. Sci Transl Med. 2017 May 31;9(392):eaal3447. doi: 10.1126/scitranslmed.aal3447. Sci Transl Med. 2017. PMID: 28566424 Free PMC article.
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.
Poole DP, Amadesi S, Veldhuis NA, Abogadie FC, Lieu T, Darby W, Liedtke W, Lew MJ, McIntyre P, Bunnett NW. Poole DP, et al. Among authors: veldhuis na. J Biol Chem. 2013 Feb 22;288(8):5790-802. doi: 10.1074/jbc.M112.438184. Epub 2013 Jan 3. J Biol Chem. 2013. PMID: 23288842 Free PMC article.
Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.
Rajasekhar P, Poole DP, Veldhuis NA. Rajasekhar P, et al. Among authors: veldhuis na. Adv Pharmacol. 2017;79:117-139. doi: 10.1016/bs.apha.2017.03.002. Epub 2017 Apr 24. Adv Pharmacol. 2017. PMID: 28528666 Review.
51 results