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Ventricular Zone Expressed PH Domain Containing 1 (VEPH1): an adaptor protein capable of modulating multiple signaling transduction pathways during normal and pathological development.
Brown TJ, Kollara A, Shathasivam P, Ringuette MJ. Brown TJ, et al. Cell Commun Signal. 2019 Sep 9;17(1):116. doi: 10.1186/s12964-019-0433-4. Cell Commun Signal. 2019. PMID: 31500637 Free PMC article. Review.
Loss of expression of its ortholog, melted, in Drosophila results in a severe neural phenotype and impacts TOR, FoxO, and Hippo signaling. Studies in mammals indicate a role for VEPH1 in modulating TGFbeta signaling and AKT activation, while numerous studies indicate VE …
Loss of expression of its ortholog, melted, in Drosophila results in a severe neural phenotype and impacts TOR, FoxO, and Hippo signaling. S …
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
Dong P, Wang X, Liu L, Tang W, Ma L, Zeng W, Sun S, Zhang L, Zhang N, Shen X, Janssen HLA, Dong L, Zhang S, Chen S. Dong P, et al. J Hepatol. 2020 Dec;73(6):1446-1459. doi: 10.1016/j.jhep.2020.06.027. Epub 2020 Jun 28. J Hepatol. 2020. PMID: 32610114
Rapamycin, the mTOR inhibitor, can inhibit the pro-tumorigenic effect of VEPH1 knockdown. Loss of VEPH1 correlates with decreased TSC2 Ser(1387) phosphorylation and increased mTOR activity in HCC specimens. CONCLUSIONS: The loss of VEPH1 leads to aberrantly a …
Rapamycin, the mTOR inhibitor, can inhibit the pro-tumorigenic effect of VEPH1 knockdown. Loss of VEPH1 correlates with decrea …
VEPH1 suppresses the progression of gastric cancer by regulating the Hippo-YAP signalling pathway.
Nie X, Zhou Z, Chen Y, Chen S, Chen Y, Lei J, Wu X, He S. Nie X, et al. Dig Liver Dis. 2024 Jan;56(1):187-197. doi: 10.1016/j.dld.2023.05.014. Epub 2023 May 25. Dig Liver Dis. 2024. PMID: 37244789 Free article.
This study investigated the expression and function of VEPH1 in human gastric cancer (GC). METHODS: We performed qRT-PCR, Western blotting, and immunostaining assays in GC tissue samples to evaluate VEPH1 expression. ...VEPH1 regulates the function of GC cell …
This study investigated the expression and function of VEPH1 in human gastric cancer (GC). METHODS: We performed qRT-PCR, Western blo …
A novel role of VEPH1 in regulating AoSMC phenotypic switching.
Shi X, Xu C, Li Y, Wang H, Ma W, Tian Y, Yang H, Li L. Shi X, et al. J Cell Physiol. 2020 Dec;235(12):9336-9346. doi: 10.1002/jcp.29736. Epub 2020 Apr 27. J Cell Physiol. 2020. PMID: 32342520
This study was thus performed to further explore the role of VEPH1. Herein, we first demonstrate that VEPH1 increases in the SMCs of Ang II-treated abdominal aortas. ...Identification of VEPH1 as a pathogenic molecule for AAA formation provides novel insights …
This study was thus performed to further explore the role of VEPH1. Herein, we first demonstrate that VEPH1 increases in the S …
The adaptor protein VEPH1 interacts with the kinase domain of ERBB2 and impacts EGF signaling in ovarian cancer cells.
Kollara A, Burt BD, Ringuette MJ, Brown TJ. Kollara A, et al. Cell Signal. 2023 Jun;106:110634. doi: 10.1016/j.cellsig.2023.110634. Epub 2023 Feb 23. Cell Signal. 2023. PMID: 36828346 Free article.
In this study, we confirm a VEPH1 - ERBB2 interaction by co-immunoprecipitation and biotin proximity labelling and show that VEPH1 interacts with the juxtamembrane-kinase domain of ERBB2. ...This study extends the range of adaptor function of VEPH1 to ERBB2, …
In this study, we confirm a VEPH1 - ERBB2 interaction by co-immunoprecipitation and biotin proximity labelling and show that VEPH1 …
Overexpressed VEPH1 inhibits epithelial-mesenchymal transition, invasion, and migration of human cutaneous melanoma cells through inactivating the TGF-beta signaling pathway.
Feng H, Jia XM, Gao NN, Tang H, Huang W, Ning N. Feng H, et al. Cell Cycle. 2019 Nov;18(21):2860-2875. doi: 10.1080/15384101.2019.1638191. Epub 2019 Sep 4. Cell Cycle. 2019. PMID: 31599708 Free PMC article. Retracted.
Finally, tumor formation in nude mice was conducted. VEPH1 was lowly expressed and regulated the progression of CM with involvement in the TGF-beta signaling pathway. ...However, si-VEPH1 or TGF-beta signaling pathway activator contributed to reverse results. ...
Finally, tumor formation in nude mice was conducted. VEPH1 was lowly expressed and regulated the progression of CM with involvement i …
VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation.
Shathasivam P, Kollara A, Spybey T, Park S, Clarke B, Ringuette MJ, Brown TJ. Shathasivam P, et al. Br J Cancer. 2017 Apr 11;116(8):1065-1076. doi: 10.1038/bjc.2017.51. Epub 2017 Mar 16. Br J Cancer. 2017. PMID: 28301874 Free PMC article.
Previous work has shown that VEPH1 inhibits TGFbeta signalling while its Drosophila ortholog increases tissue growth, raising the possibility that VEPH1 could impact tumour growth or progression. METHODS: A CRISPR approach was used to disrupt VEPH1 expression …
Previous work has shown that VEPH1 inhibits TGFbeta signalling while its Drosophila ortholog increases tissue growth, raising the pos …
Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation.
Kollara A, Shathasivam P, Park S, Ringuette MJ, Brown TJ. Kollara A, et al. J Steroid Biochem Mol Biol. 2020 Feb;196:105498. doi: 10.1016/j.jsbmb.2019.105498. Epub 2019 Oct 12. J Steroid Biochem Mol Biol. 2020. PMID: 31614206
Androgen treatment did not result in nuclear co-localization of VEPH1 with AR, suggesting that VEPH1 does not function as a nuclear co-regulatory protein. ...Treatment of cells with dihydrotestosterone (DHT) increased AR protein levels measured 24 h after treatment, …
Androgen treatment did not result in nuclear co-localization of VEPH1 with AR, suggesting that VEPH1 does not function as a nu …
MicroRNA miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway.
Fan L, Cao X, Lei Y. Fan L, et al. Bioengineered. 2021 Dec;12(2):12568-12582. doi: 10.1080/21655979.2021.2010383. Bioengineered. 2021. PMID: 34903122 Free PMC article.
Lastly, VEPH1 alleviated the promotion effect of miR-23b-3p on the malignancy phenotypes of OS cells via the PI3K/AKT signaling pathway. Thus, miR-23b-3p augmented the viability, proliferation, and migration of OS cells by directly targeting and downregulating VEPH1 …
Lastly, VEPH1 alleviated the promotion effect of miR-23b-3p on the malignancy phenotypes of OS cells via the PI3K/AKT signaling pathw …
22 results