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Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione.
Montecinos V, Guzmán P, Barra V, Villagrán M, Muñoz-Montesino C, Sotomayor K, Escobar E, Godoy A, Mardones L, Sotomayor P, Guzmán C, Vásquez O, Gallardo V, van Zundert B, Bono MR, Oñate SA, Bustamante M, Cárcamo JG, Rivas CI, Vera JC. Montecinos V, et al. Among authors: vera jc. J Biol Chem. 2007 May 25;282(21):15506-15. doi: 10.1074/jbc.M608361200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403685 Free article.
Recycling of vitamin C by a bystander effect.
Nualart FJ, Rivas CI, Montecinos VP, Godoy AS, Guaiquil VH, Golde DW, Vera JC. Nualart FJ, et al. Among authors: vera jc. J Biol Chem. 2003 Mar 21;278(12):10128-33. doi: 10.1074/jbc.M210686200. Epub 2002 Nov 14. J Biol Chem. 2003. PMID: 12435736 Free article.
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations.
Godoy A, Ormazabal V, Moraga-Cid G, Zúñiga FA, Sotomayor P, Barra V, Vasquez O, Montecinos V, Mardones L, Guzmán C, Villagrán M, Aguayo LG, Oñate SA, Reyes AM, Cárcamo JG, Rivas CI, Vera JC. Godoy A, et al. Among authors: vera jc. J Biol Chem. 2007 Jan 5;282(1):615-24. doi: 10.1074/jbc.M608300200. Epub 2006 Sep 29. J Biol Chem. 2007. PMID: 17012227 Free article.
Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization.
Ormazabal V, Zuñiga FA, Escobar E, Aylwin C, Salas-Burgos A, Godoy A, Reyes AM, Vera JC, Rivas CI. Ormazabal V, et al. Among authors: vera jc. J Biol Chem. 2010 Nov 19;285(47):36471-85. doi: 10.1074/jbc.M110.155630. Epub 2010 Sep 14. J Biol Chem. 2010. PMID: 20843809 Free PMC article.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Mardones L, Zúñiga FA, Villagrán M, Sotomayor K, Mendoza P, Escobar D, González M, Ormazabal V, Maldonado M, Oñate G, Angulo C, Concha II, Reyes AM, Cárcamo JG, Barra V, Vera JC, Rivas CI. Mardones L, et al. Among authors: vera jc. Free Radic Biol Med. 2012 May 1;52(9):1874-87. doi: 10.1016/j.freeradbiomed.2012.02.017. Epub 2012 Feb 18. Free Radic Biol Med. 2012. PMID: 22348976
Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2.
Muñoz-Montesino C, Roa FJ, Peña E, González M, Sotomayor K, Inostroza E, Muñoz CA, González I, Maldonado M, Soliz C, Reyes AM, Vera JC, Rivas CI. Muñoz-Montesino C, et al. Among authors: vera jc. Free Radic Biol Med. 2014 May;70:241-54. doi: 10.1016/j.freeradbiomed.2014.02.021. Epub 2014 Mar 2. Free Radic Biol Med. 2014. PMID: 24594434
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy.
Maldonado M, Inostroza E, Peña E, Moncada N, Mardones L, Medina JL, Muñoz A, Gatica M, Villagrán M, Escobar E, Mendoza P, Roa FJ, González M, Guzmán P, Gutiérrez-Castro FA, Sweet K, Muñoz-Montesino C, Vera JC, Rivas CI. Maldonado M, et al. Among authors: vera jc. Free Radic Biol Med. 2017 Jul;108:655-667. doi: 10.1016/j.freeradbiomed.2017.04.006. Epub 2017 Apr 15. Free Radic Biol Med. 2017. PMID: 28419867
Vitamin C transporters.
Rivas CI, Zúñiga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. Rivas CI, et al. Among authors: vera jc. J Physiol Biochem. 2008 Dec;64(4):357-75. doi: 10.1007/BF03174092. J Physiol Biochem. 2008. PMID: 19391462 Review.
137 results