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Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani JL, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P. Pedron J, et al. Among authors: verhaeghe p. Eur J Med Chem. 2018 Jul 15;155:135-152. doi: 10.1016/j.ejmech.2018.06.001. Epub 2018 Jun 5. Eur J Med Chem. 2018. PMID: 29885575 Free PMC article.
Original quinazoline derivatives displaying antiplasmodial properties.
Kabri Y, Azas N, Dumètre A, Hutter S, Laget M, Verhaeghe P, Gellis A, Vanelle P. Kabri Y, et al. Among authors: verhaeghe p. Eur J Med Chem. 2010 Feb;45(2):616-22. doi: 10.1016/j.ejmech.2009.11.005. Epub 2009 Nov 6. Eur J Med Chem. 2010. PMID: 19926173
Targeting the human malaria parasite Plasmodium falciparum: in vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series.
Castera-Ducros C, Azas N, Verhaeghe P, Hutter S, Garrigue P, Dumètre A, Mbatchi L, Laget M, Remusat V, Sifredi F, Rault S, Rathelot P, Vanelle P. Castera-Ducros C, et al. Among authors: verhaeghe p. Eur J Med Chem. 2011 Sep;46(9):4184-91. doi: 10.1016/j.ejmech.2011.06.021. Epub 2011 Jun 23. Eur J Med Chem. 2011. PMID: 21741131
Discovery of a new antileishmanial hit in 8-nitroquinoline series.
Paloque L, Verhaeghe P, Casanova M, Castera-Ducros C, Dumètre A, Mbatchi L, Hutter S, Kraiem-M'rabet M, Laget M, Remusat V, Rault S, Rathelot P, Azas N, Vanelle P. Paloque L, et al. Among authors: verhaeghe p. Eur J Med Chem. 2012 Aug;54:75-86. doi: 10.1016/j.ejmech.2012.04.029. Epub 2012 May 2. Eur J Med Chem. 2012. PMID: 22608675
Targeting the human parasite Leishmania donovani: discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series.
Castera-Ducros C, Paloque L, Verhaeghe P, Casanova M, Cantelli C, Hutter S, Tanguy F, Laget M, Remusat V, Cohen A, Crozet MD, Rathelot P, Azas N, Vanelle P. Castera-Ducros C, et al. Among authors: verhaeghe p. Bioorg Med Chem. 2013 Nov 15;21(22):7155-64. doi: 10.1016/j.bmc.2013.09.002. Epub 2013 Sep 11. Bioorg Med Chem. 2013. PMID: 24080103
Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series.
Kieffer C, Cohen A, Verhaeghe P, Hutter S, Castera-Ducros C, Laget M, Remusat V, M'Rabet MK, Rault S, Rathelot P, Azas N, Vanelle P. Kieffer C, et al. Among authors: verhaeghe p. Eur J Med Chem. 2015 Mar 6;92:282-94. doi: 10.1016/j.ejmech.2014.12.056. Epub 2014 Dec 31. Eur J Med Chem. 2015. PMID: 25559208
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
Cohen A, Suzanne P, Lancelot JC, Verhaeghe P, Lesnard A, Basmaciyan L, Hutter S, Laget M, Dumètre A, Paloque L, Deharo E, Crozet MD, Rathelot P, Dallemagne P, Lorthiois A, Sibley CH, Vanelle P, Valentin A, Mazier D, Rault S, Azas N. Cohen A, et al. Among authors: verhaeghe p. Eur J Med Chem. 2015 May 5;95:16-28. doi: 10.1016/j.ejmech.2015.03.011. Epub 2015 Mar 10. Eur J Med Chem. 2015. PMID: 25791675
229 results