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Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator linking wing, placenta, and tumor development.
Sonnemann HM, Pazdrak B, Antunes DA, Roszik J, Lizée G. Sonnemann HM, et al. Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188892. doi: 10.1016/j.bbcan.2023.188892. Epub 2023 Mar 31. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37004960 Free article. Review.
Due to its role as a driver of tumor progression, VGLL1 has become a target of interest for potential anticancer therapies. In this review, we discuss VGLL1 from an evolutionary perspective, contrast its role in placental and tumor development, summarize the current …
Due to its role as a driver of tumor progression, VGLL1 has become a target of interest for potential anticancer therapies. In this r …
VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-beta/ERK/RSK2 signaling.
Im JY, Kim DM, Park H, Kang MJ, Kim DY, Chang KY, Kim BK, Won M. Im JY, et al. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118892. doi: 10.1016/j.bbamcr.2020.118892. Epub 2020 Oct 16. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33069758 Free article.
We showed that TGF-beta enhanced VGLL1 phosphorylation and that this phosphorylated VGLL1 functioned as a transcription cofactor of TEAD4 in NUGC3 cells. ...Site-directed mutagenesis and immunoprecipitation experiments revealed that RSK2 phosphorylated VGLL1 …
We showed that TGF-beta enhanced VGLL1 phosphorylation and that this phosphorylated VGLL1 functioned as a transcription cofact …
VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.
Yang Y, Jia W, Luo Z, Li Y, Liu H, Fu L, Li J, Jiang Y, Lai J, Li H, Saeed BJ, Zou Y, Lv Y, Wu L, Zhou T, Shan Y, Liu C, Lai Y, Liu L, Hutchins AP, Esteban MA, Mazid MA, Li W. Yang Y, et al. Nat Commun. 2024 Jan 17;15(1):583. doi: 10.1038/s41467-024-44780-8. Nat Commun. 2024. PMID: 38233381 Free PMC article.
Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophoblast stem cells (TSCs), offering a valuable in vitro model to study early placenta specification. Here, we demonstrate that the VGLL1 …
Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophobl …
Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm.
Kundishora AJ, Reeves BC, Nelson-Williams C, Hong CS, Gopal PP, Snuderl M, Kahle KT, Erson-Omay EZ. Kundishora AJ, et al. Clin Genet. 2020 May;97(5):791-792. doi: 10.1111/cge.13703. Epub 2020 Jan 16. Clin Genet. 2020. PMID: 31925773 No abstract available.
N(6)-methyladenosine-modified VGLL1 promotes ovarian cancer metastasis through high-mobility group AT-hook 1/Wnt/beta-catenin signaling.
Li H, Cai L, Pan Q, Jiang X, Zhao J, Xiang T, Tang Y, Wang Q, He J, Weng D, Zhang Y, Liu Z, Xia J. Li H, et al. iScience. 2024 Feb 16;27(3):109245. doi: 10.1016/j.isci.2024.109245. eCollection 2024 Mar 15. iScience. 2024. PMID: 38439973 Free PMC article.
The role of VGLL1 in OC metastasis and tumor growth was examined by cell function assays and mouse models. ...VGLL1 might serve as a prognostic marker and therapeutic target against the metastasis of OC....
The role of VGLL1 in OC metastasis and tumor growth was examined by cell function assays and mouse models. ...VGLL1 might serv …
The Transcriptional Cofactor VGLL1 Drives Transcription of Human Papillomavirus Early Genes via TEAD1.
Mori S, Takeuchi T, Ishii Y, Kukimoto I. Mori S, et al. J Virol. 2020 May 4;94(10):e01945-19. doi: 10.1128/JVI.01945-19. Print 2020 May 4. J Virol. 2020. PMID: 32132238 Free PMC article.
Knockdown of VGLL1 and/or TEAD1 led to a decrease in viral early gene expression in human cervical keratinocytes and cervical cancer cell lines. ...Further, VGLL1 is also critical for the growth of cervical cancer cells and may represent a novel therapeutic target f …
Knockdown of VGLL1 and/or TEAD1 led to a decrease in viral early gene expression in human cervical keratinocytes and cervical cancer …
VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer.
Castilla MÁ, López-García MÁ, Atienza MR, Rosa-Rosa JM, Díaz-Martín J, Pecero ML, Vieites B, Romero-Pérez L, Benítez J, Calcabrini A, Palacios J. Castilla MÁ, et al. Endocr Relat Cancer. 2014 Aug;21(4):587-99. doi: 10.1530/ERC-13-0485. Epub 2014 Jun 2. Endocr Relat Cancer. 2014. PMID: 24891455
In this study, we examined the expression of VGLL1 and its intronic miRNA, miR-934, in breast cancer. VGLL1 and miR-934 expression miRNA profiling was carried out on frozen samples of grade 3 invasive ductal carcinomas. VGLL1 protein was also examined in 433 …
In this study, we examined the expression of VGLL1 and its intronic miRNA, miR-934, in breast cancer. VGLL1 and miR-934 expres …
The opposite effects of VGLL1 and VGLL4 genes on granulosa cell proliferation and apoptosis of hen ovarian prehierarchical follicles.
Sun X, Liswaniso S, Shan X, Zhao J, Chimbaka IM, Xu R, Qin N. Sun X, et al. Theriogenology. 2022 Mar 15;181:95-104. doi: 10.1016/j.theriogenology.2022.01.017. Epub 2022 Jan 15. Theriogenology. 2022. PMID: 35074718 Free article.
Specific small interfering RNA (siRNA) was employed to elucidate the exact roles of VGLL1 and VGLL4 in regulating the PF development of the hen ovary. ...Whereas the expression level of the cell apoptosis biomarker caspase-3 (CASP3) transcript was noticeably enhanced in th …
Specific small interfering RNA (siRNA) was employed to elucidate the exact roles of VGLL1 and VGLL4 in regulating the PF development …
VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD.
Parimita S, Das A, Samanta S. Parimita S, et al. Cell Signal. 2024 Jun;118:111120. doi: 10.1016/j.cellsig.2024.111120. Epub 2024 Feb 28. Cell Signal. 2024. PMID: 38417636
Our analysis identified EGFR as the most correlated transcript with VGLL1. We demonstrate that VGLL1 promotes EGFR expression and increases the frequency of breast tumor initiating cells (CD44(high/+)CD24(low/-)). ...In addition, we observed that VGLL1 repres …
Our analysis identified EGFR as the most correlated transcript with VGLL1. We demonstrate that VGLL1 promotes EGFR expression …
A novel EWSR1-VGLL1 gene fusion in a soft tissue malignant myoepithelial tumor.
Komatsu M, Kawamoto T, Kanzawa M, Kawakami Y, Hara H, Akisue T, Kuroda R, Nakamura H, Hokka D, Jimbo N, Itoh T, Hirose T. Komatsu M, et al. Genes Chromosomes Cancer. 2020 Apr;59(4):249-254. doi: 10.1002/gcc.22823. Epub 2019 Nov 18. Genes Chromosomes Cancer. 2020. PMID: 31697442
Next-generation RNA sequencing identified a novel fusion transcript, in which the in-frame junctional reads contained exon 9 of EWSR1 and exon 2 of VGLL1, resulting in the formation of a putative chimeric protein with the N-terminal transcriptional activation domain of EWS …
Next-generation RNA sequencing identified a novel fusion transcript, in which the in-frame junctional reads contained exon 9 of EWSR1 and ex …
36 results