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Year Number of Results
2009 2
2010 2
2011 2
2012 2
2013 2
2014 4
2015 4
2016 3
2017 5
2018 3
2019 5
2020 17
2021 15
2022 28
2023 18
2024 16

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115 results

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VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
Horii Y, Matsuda S, Toyota C, Morinaga T, Nakaya T, Tsuchiya S, Ohmuraya M, Hironaka T, Yoshiki R, Kasai K, Yamauchi Y, Takizawa N, Nagasaka A, Tanaka A, Kosako H, Nakaya M. Horii Y, et al. Nat Commun. 2023 Feb 8;14(1):550. doi: 10.1038/s41467-023-36189-6. Nat Commun. 2023. PMID: 36754961 Free PMC article.
Further, substrate stiffness triggers VGLL3 translocation into the nucleus through the integrin beta1-Rho-actin pathway. ...VGLL3 binds EWSR1 and suppresses miR-29b, which targets collagen mRNA. ...
Further, substrate stiffness triggers VGLL3 translocation into the nucleus through the integrin beta1-Rho-actin pathway. ...VGLL3 …
VGLL3 confers slow-twitch muscle differentiation via PGC-1alpha expression in C2C12 myocytes.
Takakura Y, Suzuki T, Hirai N, Araki T, Ohishi M, Sato H, Yamaguchi N, Takano H, Yamaguchi N. Takakura Y, et al. Biochem Biophys Res Commun. 2023 Aug 20;669:30-37. doi: 10.1016/j.bbrc.2023.05.073. Epub 2023 May 20. Biochem Biophys Res Commun. 2023. PMID: 37262950
In this study, we established a cell line stably overexpressing VGLL3 and analyzed effects of VGLL3 on the myogenic differentiation of murine myoblast C2C12 cells. ...We also found that VGLL3 proteins are degraded by the proteasome, which causes switching of …
In this study, we established a cell line stably overexpressing VGLL3 and analyzed effects of VGLL3 on the myogenic differenti …
VGLL3 activates inflammatory responses by inducing interleukin-1alpha secretion.
Takakura Y, Hori N, Terada N, Machida M, Yamaguchi N, Takano H, Yamaguchi N. Takakura Y, et al. FASEB J. 2021 Nov;35(11):e21996. doi: 10.1096/fj.202100679RR. FASEB J. 2021. PMID: 34679187
Although elevation in VGLL3 expression is associated with inflammatory diseases, such as inflammatory sarcomas and autoimmune diseases, the molecular mechanisms underlying VGLL3-mediated inflammation remain largely unknown. ...NF-kappaB was found to be activated in …
Although elevation in VGLL3 expression is associated with inflammatory diseases, such as inflammatory sarcomas and autoimmune disease …
Linking vgll3 genotype and aggressive behaviour in juvenile Atlantic salmon (Salmo salar).
Bangura PB, Tiira K, Niemelä PT, Erkinaro J, Liljeström P, Toikkanen A, Primmer CR. Bangura PB, et al. J Fish Biol. 2022 May;100(5):1264-1271. doi: 10.1111/jfb.15040. Epub 2022 Mar 29. J Fish Biol. 2022. PMID: 35289932 Free PMC article.
We tested the possibility that vgll3, a gene linked with maturation age in Atlantic salmon (Salmo salar), may be associated with behaviour by measuring aggressiveness and feeding activity in 380 juveniles with different vgll3 genotypes. Contrary to our prediction, i …
We tested the possibility that vgll3, a gene linked with maturation age in Atlantic salmon (Salmo salar), may be associated with beha …
VGLL3 expression is associated with macrophage infiltration and predicts poor prognosis in epithelial ovarian cancer.
Haque R, Lee J, Chung JY, Shin HY, Kim H, Kim JH, Yun JW, Kang ES. Haque R, et al. Front Oncol. 2023 Jun 5;13:1152991. doi: 10.3389/fonc.2023.1152991. eCollection 2023. Front Oncol. 2023. PMID: 37342190 Free PMC article.
The result of IHC analysis also supported the association of VGLL3 protein with poor OS. Further, VGLL3 expression was significantly associated with tumor infiltrating macrophages. ...VGLL3 was associated with four known and three novel cancer-related signall …
The result of IHC analysis also supported the association of VGLL3 protein with poor OS. Further, VGLL3 expression was signifi …
VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
Kawamura T, Takehora Y, Hori N, Takakura Y, Yamaguchi N, Takano H, Yamaguchi N. Kawamura T, et al. J Cell Biochem. 2022 Jun;123(6):1064-1076. doi: 10.1002/jcb.30251. Epub 2022 Apr 17. J Cell Biochem. 2022. PMID: 35434822
Vestigial-like family member 3 (VGLL3) is a member of the VGLL family that serves as cofactors for TEA-domain transcription factors. Although VGLL3 is involved in the proliferation of cancer cells, the molecular mechanisms underlying VGLL3-mediated cell proli …
Vestigial-like family member 3 (VGLL3) is a member of the VGLL family that serves as cofactors for TEA-domain transcription factors. …
The immunometabolic function of VGLL3 and female-biased autoimmunity.
Kennicott K, Liang Y. Kennicott K, et al. Immunometabolism (Cobham). 2024 May 8;6(2):e00041. doi: 10.1097/IN9.0000000000000041. eCollection 2024 Apr. Immunometabolism (Cobham). 2024. PMID: 38726338 Free PMC article. Review.
This role of VGLL3 may confer a selective advantage during the evolution of placental mammals. However, the excessive activation of the VGLL3-mediated energy-sensing pathway can trigger inflammatory cell death and the exposure of self-antigens, leading to the onset …
This role of VGLL3 may confer a selective advantage during the evolution of placental mammals. However, the excessive activation of t …
lncRNA Vgll3 Regulates the Activated Proliferation of Mouse Myocardial Fibroblasts through TGF-beta3-Related Pathway.
Liu B, Chen M, Meng W. Liu B, et al. Biomed Res Int. 2022 Aug 21;2022:2055738. doi: 10.1155/2022/2055738. eCollection 2022. Biomed Res Int. 2022. PMID: 36046460 Free PMC article. Retracted.
Upregulation of Vgll3 significantly promoted the activation and proliferation of mouse CFs cells. It promoted the mRNA and protein levels of alpha-SMA, Fn, Col1, and Col3, while silencing the expression of Vgll3 had the opposite effect. The above effects of upregula …
Upregulation of Vgll3 significantly promoted the activation and proliferation of mouse CFs cells. It promoted the mRNA and protein le …
CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin alpha5 expression.
Zhang D, Ni N, Wang Y, Tang Z, Gao H, Ju Y, Sun N, He X, Gu P, Fan X. Zhang D, et al. Cell Death Differ. 2021 Jan;28(1):283-302. doi: 10.1038/s41418-020-0600-6. Epub 2020 Aug 19. Cell Death Differ. 2021. PMID: 32814879 Free PMC article.
Furthermore, we validate that circRNA-vgll3 functions in ADSC osteogenesis through a circRNA-vgll3/miR-326-5p/integrin alpha5 (Itga5) pathway. ...This study reveals the important role of circRNA-vgll3 during new bone biogenesis. Thus, circRNA-vgll3 eng …
Furthermore, we validate that circRNA-vgll3 functions in ADSC osteogenesis through a circRNA-vgll3/miR-326-5p/integrin alpha5 …
Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.
Dickson BC, Antonescu CR, Demicco EG, Leong DI, Anderson ND, Swanson D, Zhang L, Fletcher CDM, Hornick JL. Dickson BC, et al. Mod Pathol. 2021 Jun;34(6):1116-1124. doi: 10.1038/s41379-021-00783-0. Epub 2021 Mar 1. Mod Pathol. 2021. PMID: 33649458 Free PMC article.
The molecular pathogenesis of these so-called "hybrid" tumors remains poorly understood. Following identification of a novel CHD7-VGLL3 fusion gene in a hybrid schwannoma-perineurioma, we evaluated an expanded cohort of this tumor-type-as well as tumors with VGLL3 r …
The molecular pathogenesis of these so-called "hybrid" tumors remains poorly understood. Following identification of a novel CHD7-VGLL3 …
115 results