ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome.
Cheong M, Gartlan KH, Lee JS, Tey SK, Zhang P, Kuns RD, Andoniou CE, Martins JP, Chang K, Sutton VR, Kelly G, Varelias A, Vuckovic S, Markey KA, Boyle GM, Smyth MJ, Engwerda CR, MacDonald KPA, Trapani JA, Degli-Esposti MA, Koyama M, Hill GR.
Cheong M, et al.
Cancer Immunol Res. 2020 Aug;8(8):1085-1098. doi: 10.1158/2326-6066.CIR-19-0653. Epub 2020 May 22.
Cancer Immunol Res. 2020.
PMID: 32444423
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure responsible for processing I …
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, whic …