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Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia.
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D, Morales V, Finch AJ, D'Alessandro A, Bianchi K, Wang J, Gallipoli P, Kordasti S, Kubasch AS, Cross M, Platzbecker U, Wiseman DH, Bonnet D, Bernard DG, Gribben JG, Rouault-Pierre K. Mian SA, et al. Sci Transl Med. 2023 Mar;15(685):eabn5135. doi: 10.1126/scitranslmed.abn5135. Epub 2023 Mar 1. Sci Transl Med. 2023. PMID: 36857430 Free PMC article.
In patients with MDS-RS, loss of protein due to COASY mis-splicing led to depletion of both CoA and succinyl-CoA. Supplementation with COASY substrate (vitamin B5) rescued CoA and succinyl-CoA concentrations in SF3B1(mut) cells and mended erythropoiesis differentiat …
In patients with MDS-RS, loss of protein due to COASY mis-splicing led to depletion of both CoA and succinyl-CoA. Supplementation with COASY …
Hydrosoluble vitamins.
Chawla J, Kvarnberg D. Chawla J, et al. Handb Clin Neurol. 2014;120:891-914. doi: 10.1016/B978-0-7020-4087-0.00059-0. Handb Clin Neurol. 2014. PMID: 24365359 Review.
The B group vitamins include thiamin (vitamin B1), riboflavin (vitamin B2), niacin or niacinamide (vitamin B3), pantothenic acid (vitamin B5), pyridoxine or pyridoxal (vitamin B6) and cobalamin (vitamin B12). ...
The B group vitamins include thiamin (vitamin B1), riboflavin (vitamin B2), niacin or niacinamide (vitamin B3), pantothenic acid (vitamin
Vitamin B5 (Pantothenic Acid).
Sanvictores T, Chauhan S. Sanvictores T, et al. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33085380 Free Books & Documents.
Vitamin B5, also known as pantothenic acid, is a water-soluble nutrient necessary for various metabolic functions within the body. This essential vitamin participates in energy generation, synthesizing hormones, and maintaining optimal conditions for skin, hair, and
Vitamin B5, also known as pantothenic acid, is a water-soluble nutrient necessary for various metabolic functions within the b
Role of Vitamins in Neurodegenerative Diseases: A Review.
Kumar RR, Singh L, Thakur A, Singh S, Kumar B. Kumar RR, et al. CNS Neurol Disord Drug Targets. 2022;21(9):766-773. doi: 10.2174/1871527320666211119122150. CNS Neurol Disord Drug Targets. 2022. PMID: 34802410 Review.
In Huntington's disease, vitamin- C deficiency decreases the antioxidant level, enhances oxidative stress, and disrupts the glucose cycle. vitamin B5 deficiency in Huntington's disease disrupts the synthesis of acetylcholine and hormones in the brain....
In Huntington's disease, vitamin- C deficiency decreases the antioxidant level, enhances oxidative stress, and disrupts the glucose cycle. …
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, Toker A. Dibble CC, et al. Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27. Nature. 2022. PMID: 35896750 Free PMC article.
CoA is the major carrier of activated acyl groups in cells(4,5) and is synthesized from cysteine, ATP and the essential nutrient vitamin B5 (also known as pantothenate)(6,7). We identify pantothenate kinase 2 (PANK2) and PANK4 as substrates of the PI3K effector kina …
CoA is the major carrier of activated acyl groups in cells(4,5) and is synthesized from cysteine, ATP and the essential nutrient vitamin
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy.
Bourgin M, Kepp O, Kroemer G. Bourgin M, et al. Oncoimmunology. 2022 Jan 25;11(1):2031500. doi: 10.1080/2162402X.2022.2031500. eCollection 2022. Oncoimmunology. 2022. PMID: 35096488 Free PMC article.
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. ...These finding suggest that vitamin B5 is yet another B vitamin that stimulates anti-cancer immunosurveill
Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intes
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
Chen C, Zhang W, Zhou T, Liu Q, Han C, Huang Z, Chen S, Mei Q, Zhang C, Zhang K, Ma H, Zhou R, Jiang W, Pan W, Zhu S. Chen C, et al. Cell Rep. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. Cell Rep. 2022. PMID: 36450257 Free article.
Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) restrains Th17 cell differentiation as well as related autoimmune diseases such as experimental autoimmune encephalomyelitis and colitis. ...
Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) re …
The vitamin B5/coenzyme A axis: A target for immunomodulation?
Miallot R, Millet V, Galland F, Naquet P. Miallot R, et al. Eur J Immunol. 2023 Oct;53(10):e2350435. doi: 10.1002/eji.202350435. Epub 2023 Jul 28. Eur J Immunol. 2023. PMID: 37482959 Review.
This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin B5/pantothenate in vivo and modulating the development of Th17-mediated inflammation, CD8-dependent anti-tumor immunity but also tissue …
This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin
Las deficiencias más significativas de macro y micro nutrientes en adolescentes que viven con el VIH/sida en terapia anti-retroviral.
Bissigo Pereira F, Miraglia F, Barbosa Schmitz C, Oliveira da Silva CL, Ramos Lazzarotto A. Bissigo Pereira F, et al. Nutr Hosp. 2016 Feb 16;33(1):21-25. doi: 10.20960/nh.v33i1.10. Nutr Hosp. 2016. PMID: 27019237 Free article. English.
The participants intake of total calories, total fiber (g/d), liposoluble vitamins (A, D, E, K), vitamin B5 (mg/d), vitamin B9 (mg/d), vitamin C (mg/d), calcium (mg/d), phosphorus (mg/d), potassium (mg/d), and magnesium (mg/d) was lower than recommended. The percent …
The participants intake of total calories, total fiber (g/d), liposoluble vitamins (A, D, E, K), vitamin B5 (mg/d), vitamin B9 …
Cross-kingdom vitamin B5 biosynthesis and cyst nematode susceptibility.
Li M, Guo B, Liu F, Fu ZQ. Li M, et al. Trends Parasitol. 2023 Jan;39(1):7-9. doi: 10.1016/j.pt.2022.11.004. Epub 2022 Nov 26. Trends Parasitol. 2023. PMID: 36443162
Vitamin deficiencies are known to cause disorders in human beings. Siddique et al. discovered that vitamin B5 biosynthesis in cyst nematodes requires steps in their host plants. Disruption of an Arabidopsis thaliana 'susceptibility gene', which is involved in the pr …
Vitamin deficiencies are known to cause disorders in human beings. Siddique et al. discovered that vitamin B5 biosynthesis in …
250 results