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Table representation of search results timeline featuring number of search results per year.

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1998 1
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2006 1
2007 5
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2010 3
2011 5
2012 3
2013 9
2014 12
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2016 11
2017 4
2018 6
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127 results

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Page 1
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis.
Millet V, Gensollen T, Maltese M, Serrero M, Lesavre N, Bourges C, Pitaval C, Cadra S, Chasson L, Vu Man TP, Masse M, Martinez-Garcia JJ, Tranchida F, Shintu L, Mostert K, Strauss E, Lepage P, Chamaillard M, Broggi A, Peyrin-Biroulet L, Grimaud JC, Naquet P, Galland F. Millet V, et al. Gut. 2023 Jun;72(6):1115-1128. doi: 10.1136/gutjnl-2021-325792. Epub 2022 Sep 29. Gut. 2023. PMID: 36175116
We developed a pharmacological mimicry of Vnn1 overexpression by administration of Vnn1 derivatives. RESULTS: VNN1 overexpression on colonocytes correlates with IBD severity. ...In addition, we identify the elevation of indoxyl sulfate in urine as a biomarker …
We developed a pharmacological mimicry of Vnn1 overexpression by administration of Vnn1 derivatives. RESULTS: VNN1 over …
VNN1 contributes to the acute kidney injury-chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression.
Chen J, Lu H, Wang X, Yang J, Luo J, Wang L, Yi X, He Y, Chen K. Chen J, et al. FASEB J. 2022 Sep;36(9):e22472. doi: 10.1096/fj.202200496RR. FASEB J. 2022. PMID: 35959877
Here, we explored the roles and mechanisms of VNN1 in the progression of the AKI-CKD transition. We observed that VNN1 expression was upregulated after ischemia/reperfusion (I/R) injury and high VNN1 expression levels were associated with poor renal repair af …
Here, we explored the roles and mechanisms of VNN1 in the progression of the AKI-CKD transition. We observed that VNN1 express …
Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.
Xiang H, Guo F, Tao X, Zhou Q, Xia S, Deng D, Li L, Shang D. Xiang H, et al. Theranostics. 2021 Mar 4;11(9):4467-4482. doi: 10.7150/thno.54245. eCollection 2021. Theranostics. 2021. PMID: 33754072 Free PMC article.
Moreover, molecular docking and mutant plasmid experiments proved that S100A9 has a direct interaction with VNN1 through the salt bridges formation of Lys57 and Glu92 residues in S100A9 protein. We further found that compounds C(42)H(60)N(4)O(6) and C(28)H(29)F(3)N(4)O(5)S …
Moreover, molecular docking and mutant plasmid experiments proved that S100A9 has a direct interaction with VNN1 through the salt bri …
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy.
Yu H, Cui Y, Guo F, Zhu Y, Zhang X, Shang D, Dong D, Xiang H. Yu H, et al. Eur J Pharmacol. 2024 Jan 5;962:176220. doi: 10.1016/j.ejphar.2023.176220. Epub 2023 Dec 1. Eur J Pharmacol. 2024. PMID: 38042463 Free article. Review.
In recent years, the crosstalk between VNN1 and metabolism and oxidative stress has attracted much attention. ...This review discusses the functions of VNN1 in glucolipid metabolism, cysteamine metabolism, and glutathione metabolism to provide perspectives on VNN …
In recent years, the crosstalk between VNN1 and metabolism and oxidative stress has attracted much attention. ...This review discusse …
VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing beta-cell dedifferentiation.
Qin W, Kang M, Li C, Zheng W, Guo Q. Qin W, et al. Oncol Rep. 2023 Jun;49(6):120. doi: 10.3892/or.2023.8557. Epub 2023 Apr 28. Oncol Rep. 2023. PMID: 37114564 Free PMC article.
Vanin-1 (VNN1) may be a potential biomarker for the early screening of pancreatic cancer (PC)-associated diabetes (PCAD). ...PC-derived VNN1 could be transported into islets through PC cell-derived Exos (PC-Exos). ...
Vanin-1 (VNN1) may be a potential biomarker for the early screening of pancreatic cancer (PC)-associated diabetes (PCAD). ...PC-deriv …
Role of the Vnn1 pantetheinase in tissue tolerance to stress.
Naquet P, Pitari G, Duprè S, Galland F. Naquet P, et al. Biochem Soc Trans. 2014 Aug;42(4):1094-100. doi: 10.1042/BST20140092. Biochem Soc Trans. 2014. PMID: 25110008 Review.
Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the present article, we review the results showing the regulation of Vnn1 expression during developmental, repair and inflammatory situation …
Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the pre …
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q. Hu YW, et al. J Lipid Res. 2016 Aug;57(8):1398-411. doi: 10.1194/jlr.M065565. Epub 2016 Jun 8. J Lipid Res. 2016. PMID: 27281478 Free PMC article.
Accumulated evidence shows that vanin-1 (VNN1) plays a key part in glucose metabolism. We explored the effect of VNN1 on cholesterol metabolism, inflammation, apoptosis in vitro, and progression of atherosclerotic plaques in apoE(-/-) mice. ...Consistent with these …
Accumulated evidence shows that vanin-1 (VNN1) plays a key part in glucose metabolism. We explored the effect of VNN1 on chole …
VNN1 as a potential biomarker for sepsis diagnosis and its implications in immune infiltration and tumor prognosis.
Guan W, Xu J, Shi Y, Wang X, Gu S, Xie L. Guan W, et al. Front Med (Lausanne). 2023 Aug 7;10:1236484. doi: 10.3389/fmed.2023.1236484. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37608823 Free PMC article.

RESULTS: Twelve genes related to fatty acid metabolism were excluded. CA4, OLAN, and VNN1 were found relevant to immune cells and function. Among these, only VNN1 showed statistical significance (p < 0.05), with a strong area under the ROC curve (0.995). ...VN

…
RESULTS: Twelve genes related to fatty acid metabolism were excluded. CA4, OLAN, and VNN1 were found relevant to immune cells and fun …
VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress.
Kang M, Qin W, Buya M, Dong X, Zheng W, Lu W, Chen J, Guo Q, Wu Y. Kang M, et al. Cancer Lett. 2016 Apr 10;373(2):241-50. doi: 10.1016/j.canlet.2015.12.031. Epub 2016 Feb 1. Cancer Lett. 2016. PMID: 26845448
The functional mechanisms of VNN1 in the pathogenesis of PCAND, however, are not completely understood. ...The molecules downstream of VNN1 are also potential biomarkers for PCAND screening....
The functional mechanisms of VNN1 in the pathogenesis of PCAND, however, are not completely understood. ...The molecules downstream o …
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Giessner C, Millet V, Mostert KJ, Gensollen T, Vu Manh TP, Garibal M, Dieme B, Attaf-Bouabdallah N, Chasson L, Brouilly N, Laprie C, Lesluyes T, Blay JY, Shintu L, Martin JC, Strauss E, Galland F, Naquet P. Giessner C, et al. Life Sci Alliance. 2018 Jul 23;1(4):e201800073. doi: 10.26508/lsa.201800073. eCollection 2018 Aug. Life Sci Alliance. 2018. PMID: 30456364 Free PMC article.
Using two models, we show that Vnn1(+) STS remain differentiated and grow slowly, and that in patients a detectable level of VNN1 expression in STS is associated with an improved prognosis. ...We propose that the Warburg effect observed in aggressive STS is reversed …
Using two models, we show that Vnn1(+) STS remain differentiated and grow slowly, and that in patients a detectable level of VNN1 …
127 results